| 范梅吟,但 超,王峥嵘,徐 洋,姜晓颖.新生血管性年龄相关性黄斑变性对抗VEGF治疗的耐药性危险因素分析[J].,2022,(11):2061-2065 |
| 新生血管性年龄相关性黄斑变性对抗VEGF治疗的耐药性危险因素分析 |
| Risk Factors Analysis of Resistance to VEGF Therapy in Neovascular Age-related Macular Degeneration |
| 投稿时间：2021-10-27 修订日期：2021-11-23 |
| DOI：10.13241/j.cnki.pmb.2022.11.011 |
| 中文关键词: 新生血管性年龄相关性黄斑变性 VEGF治疗 耐药性 危险因素 |
| 英文关键词: Neovascular age-related macular degeneration VEGF treatment Drug resistance Risk factors |
| 基金项目:湖北省卫生健康委2021-2022年度面上项目（WJ2021M238） |
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| 中文摘要: |
| 摘要 目的：探究新生血管性年龄相关性黄斑变性对抗血管内皮生长因子（VEGF）治疗的耐药性危险因素。方法：选取2019年5月至2021年5月于我院接受治疗的90例nAMD患者作为研究对象，进行VEGF治疗，根据患者的耐药情况将其分为耐药组（n=19）和非耐药组（n=71），统计患者资料，对比分析产生耐药性的危险因素。结果：危险因素与AMD类型、PED、椭圆体带完整性、积液、出血、BCVA、眼压、CRT异常有关（P<0.05），危险因素与性别和平均年龄无关（P>0.05）；Ⅰ型CNV患者在VEGF治疗前后CRT水平未出现显著变化（P>0.05），II型CNV患者和混合型CNV患者治疗前后CRT水平均显著降低（P<0.05）。Logistic回归分析显示：最终进入主效应模型的因素即抗VEGF治疗的耐药性发生的多因素为积液、PED、出血、AMD类型。结论：新生血管性年龄相关性黄斑变性（nAMD）对抗VEGF治疗出现耐药性与积液、出血和AMD类型有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the risk factors for resistance to VEGF therapy in neovascular age-related macular degeneration. Methods: 90 patients with nAMD who received treatment in our hospital from May 2019 to May 2021 were selected as the research objects and treated with VEGF. According to their drug resistance, the patients were divided into drug-resistant group (n=19) and non-resistant group (n=71). The data of the patients were collected and the risk factors for drug resistance were analyzed. Results: Univariate analysis of risk factors for anti-VEGF treatment resistance showed that risk factors were associated with AMD type, PED, ellipsoid band integrity, effusion, hemorrhage, BCVA, intraocular pressure and CRT abnormalities (P<0.05), but not with gender and average age(P>0.05). There was no change in the level of CRT in type IⅠ-type CNV patients before and after VEGF treatment(P>0.05), and the level of CRT in type IⅠ-type CNV patients and mixed CNV patients was decreased before and after VEGF treatment (P<0.05). Multivariate Logistic regression analysis of drug resistance of anti-VEGF therapy showed that the factors that finally entered the main effect model, namely, the multifactors of drug resistance of anti-VEGF therapy were effusion, PED, bleeding and AMD. Conclusion: Resistance to VEGF therapy in neovascular age-related macular degeneration is associated with fluid accumulation, bleeding, and AMD type. |
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