| 曼热帕· 吐尔逊,祖力皮艳· 阿不力克木,阿力亚· 阿布都热扎克,陈贵红,刘艳佳,丁 岩.乌鲁木齐市及阿克苏地区早发性卵巢功能不全影响因素的多中心研究[J].,2022,(10):1991-1995 |
| 乌鲁木齐市及阿克苏地区早发性卵巢功能不全影响因素的多中心研究 |
| Multicenter Study on Influencing Factors of Premature Ovarian Insufficiency in Urumqi and Aksu Region |
| 投稿时间：2022-01-05 修订日期：2022-01-28 |
| DOI：10.13241/j.cnki.pmb.2022.10.040 |
| 中文关键词: 乌鲁木齐市 阿克苏地区 早发性卵巢功能不全 影响因素 多中心研究 |
| 英文关键词: Urumqi Aksu region Premature ovarian insufficiency Influencing factors Multicenter study |
| 基金项目:新疆维吾尔自治区自然科学基金青年基金项目（2019D01C303） |
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| 中文摘要: |
| 摘要 目的：分析新疆乌鲁木齐市及阿克苏地区早发性卵巢功能不全（POI）影响因素。方法：选取2019年1月~2021年12月期间新疆典型地域分布代表的乌鲁木齐市及阿克苏地区不同等级医院妇科收治的POI患者确定为病例组，共计186例。同时选取同期来新疆典型地域分布代表的乌鲁木齐市及阿克苏地区不同等级医院进行体检的200例无POI健康育龄期妇女志愿者作为对照组。采用本次研究自制的调查量表搜集患者的一般资料，采用单因素及多因素Logistic回归分析POI的影响因素。结果：病例组血清基础卵泡刺激素（FSH）、促黄体生成素（LH）水平高于对照组、雌二醇（E2）水平低于对照组（P<0.05）。单因素的研究结果显示，对照组、病例组在民族、居住地、文化水平、是否经常锻炼/劳动、月经量、月经周期是否有规律、是否存在内分泌疾病、是否存在妇科疾病（除POI）、是否盆腔手术、月经天数、月经周期、Zung抑郁自评量表（SDS）得分方面具有统计学差异（P<0.05）。多因素Logistic回归分析结果显示，民族为汉族、学历为大学及以上、月经周期一直无规律、进行过盆腔手术、SDS得分偏高、月经量很少是POI发生的危险因素（P<0.05），而经常锻炼/劳动是POI发生的保护因素（P<0.05）。结论：新疆乌鲁木齐市及阿克苏地区的POI患者体内性激素紊乱，且其POI的发生受到民族、学历、是否经常锻炼/劳动等多种因素的影响。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the influencing factors of premature ovarian insufficiency (POI) in Urumqi and Aksu region, Xinjiang. Methods: From January 2019 to December 2021, 186 patients with POI who were treated in gynecological hospitals at different levels in Urumqi and Aksu, which are representative of typical regional distribution in Xinjiang, were selected as the case group. At the same time, 200 healthy women volunteers of childbearing age without POI who came to gynecological hospitals at different levels in Urumqi and Aksu, which are representative of typical regional distribution in Xinjiang for physical examination in the same period were selected as the control group. The self-made survey scale was used to collect the general data of patients, and the influencing factors of POI were analyzed by univariate and multivariate Logistic regression. Results: The levels of serum basal follicle stimulating hormone (FSH) and luteinizing hormone (LH) in the case group were higher than those in the control group, and the level of estradiol (E2) was lower than that in the control group (P<0.05). The results of univariate study showed that there were significant differences between the control group and the case group in nationality, residence, educational level, whether they regular exercise/labor, menstrual volume, whether the menstrual cycle was regular, whether there were endocrine diseases, whether there were gynecological diseases (except POI), whether pelvic surgery, menstrual days, menstrual cycle and the Zung self rating Depression Scale (SDS) score (P<0.05). Multivariate Logistic regression analysis showed that Han nationality, university degree or above, menstrual cycle had been irregular, had pelvic surgery, high SDS score and little menstrual volume were the risk factors of POI (P<0.05), while regular exercise/labor was the protective factor of POI (P<0.05). Conclusion: The patients with POI in Urumqi and Aksu region of Xinjiang have sex hormone disorder, and the occurrence of POI is affected by many factors, such as nationality, education background, and whether they regularly exercise/work. |
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