| 云大科,符丽娜,纪志华,焦 拓,胡 帅,贾丙申.骨愈灵片联合依降钙素注射液对骨质疏松症患者Oswestry功能障碍指数评分及骨密度、骨代谢指标的影响[J].,2022,(10):1986-1990 |
| 骨愈灵片联合依降钙素注射液对骨质疏松症患者Oswestry功能障碍指数评分及骨密度、骨代谢指标的影响 |
| Effects of Guyuling Tablet Combined with Elcatonin Injection on Oswestry Dysfunction Index Score, Bone Mineral Density and Bone Metabolism Index in Patients with Osteoporosis |
| 投稿时间：2021-10-23 修订日期：2021-11-18 |
| DOI：10.13241/j.cnki.pmb.2022.10.039 |
| 中文关键词: 骨愈灵片 依降钙素注射液 骨质疏松症 Oswestry功能障碍指数 骨密度 骨代谢 |
| 英文关键词: Guyuling tablet Elcatonin injection Osteoporosis Oswestry dysfunction index Bone mineral density Bone metabolism |
| 基金项目:海南省卫生计生行业科研项目普通科研课题（20A200507） |
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| 中文摘要: |
| 摘要 目的：探讨骨愈灵片联合依降钙素注射液对骨质疏松症患者Oswestry功能障碍指数（ODI）评分及骨密度、骨代谢指标的影响。方法：选择我院2018年3月~2021年2月间收治的骨质疏松症患者156例，采用随机数字表法分为对照组（采用依降钙素注射液治疗）和研究组（采用骨愈灵片联合依降钙素注射液治疗），各为78例。观察两组疗效、不良反应，对比两组ODI评分、腰椎L2-L4、桡骨远端1/3处和股骨颈的骨密度、骨代谢指标[血钙 、血磷 、骨钙素（BGP）和β-胶原降解产物（β-CTX）]、炎性指标[促生长因子（IGF-1）、白介素-1（IL-1）、白介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）]水平。结果：研究组的临床总有效率明显高于对照组（P<0.05）。研究组治疗结束后ODI评分低于对照组（P<0.05）。两组不良反应发生率对比无差异（P>0.05）。研究组治疗结束后腰椎L2-L4、桡骨远端1/3处、股骨颈骨密度均大于对照组（P<0.05）。研究组治疗结束后血钙、BGP水平高于对照组，血磷、β-CTX水平低于对照组（P<0.05）。研究组治疗结束后IGF-1水平高于对照组，IL-1、IL-8、TNF-α水平低于对照组（P<0.05）。结论：骨质疏松症患者采用依降钙素注射液联合骨愈灵片治疗，可改善骨代谢和骨密度，调节炎性因子水平，促进机体功能恢复，疗效明确。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effects of Guyuling tablet combined with elcatonin injection on Oswestry dysfunction index score,bone mineral density and bone metabolism index in patients with osteoporosis. Methods: 156 patients with osteoporosis who were treated in our hospital from March 2018 to February 2021 were selected, and the patients were divided into control group (treated with elcatonin injection) and study group (treated with Guyuling tablet combined with elcatonin injection) by random number table method, with 78 cases in each group. The efficacy and adverse reactions of the two groups were observed. The Oswestry dysfunction index (ODI) score, bone mineral density of lumbar spine L2-L4, 1 /3 of distal radius and femoral neck, and the levels of Bone metabolism indexes [blood calcium, blood phosphorus, osteocalcin (BGP) and β- Collagen degradation products(β-CTX)], inflammatory indexes [growth promoting factor (IGF-1), interleukin-1 (IL-1), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α)] were compared between the two groups. Results: The total clinical effective rate of the study group was significantly higher than that of the control group (P<0.05). The ODI score of the study group was lower than that of the control group after treatment (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). After treatment, the BMD of lumbar L2-L4, 1/3 of distal radius and femoral neck in the study group were higher than those in the control group (P<0.05). After treatment, blood calcium and BGP levels in the study group were higher than those in the control group, β-CTX level was lower than that in the control group (P<0.05). After treatment, IGF-1 level in the study group was higher than that in the control group, IL-1, IL-8 and TNF-α levels were lower than that in the control group (P<0.05). Conclusion: The treatment of patients with osteoporosis with elcatonin injection combined with Guyuling tablet can improve bone metabolism and bone mineral density, regulate the level of inflammatory factors and promote the recovery of body function. |
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