| 郭小英,谢海林,祈秉民,韩启福,李 娟.肺癌患者外周血T淋巴细胞分型与抗核抗体之间的关系研究[J].,2022,(10):1960-1963 |
| 肺癌患者外周血T淋巴细胞分型与抗核抗体之间的关系研究 |
| Relationship between the Typing of T Lymphocytes in Peripheral Blood of Patients with Lung Cancer and Antinuclear Antibodies |
| 投稿时间：2021-10-17 修订日期：2021-11-12 |
| DOI：10.13241/j.cnki.pmb.2022.10.034 |
| 中文关键词: 肺癌 T淋巴细胞 抗核抗体 |
| 英文关键词: Lung cancer T lymphocytes Antinuclear antibodies |
| 基金项目:青海省科技计划项目（2019-ZJ-T06） |
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| 中文摘要: |
| 摘要 目的：研究肺癌患者外周血T淋巴细胞分型与抗核抗体之间的关系。方法：选择2019年1月到2021年6月在我院接受治疗的肺癌患者81例作为研究组，并选择同期健康志愿者81例作为对照组，检测并比较两组患者外周血CD4+、CD8+和CD4+/CD8+淋巴细胞比例，以及抗核抗体血清滴度。比较不同抗核抗体、年龄、性别、TNM分期、肿瘤分化程度以及病理类型肺癌患者外周血CD4+、CD8+和CD4+/CD8+淋巴细胞比例。结果：（1）肺癌患者外周血CD4+和CD4+/CD8+淋巴细胞比例显著低于对照组，而CD8+淋巴细胞比例显著高于对照组（P<0.05）；（2）III+IV肺癌患者外周血CD4+、和CD4+/CD8+淋巴细胞比例均显著低于I+II肺癌患者，而CD8+淋巴细胞比例均显著高于I+II肺癌患者（P<0.05）；（3）小细胞肺癌患者外周血CD4+、和CD4+/CD8+淋巴细胞比例均显著低于非小肺癌患者，而CD8+淋巴细胞比例均显著高于非小肺癌患者（P<0.05）；（4）肺癌患者抗核抗体血清滴度显著高于对照组（P<0.05）；（5）抗核抗体阳性患者CD4+和CD4+/CD8+淋巴细胞亚群比例均显著低于抗核抗体阴性患者，而CD8+淋巴细胞亚群比例显著高于抗核抗体阴性患者（P<0.05）。结论：肺癌患者外周血T淋巴细胞亚群表达异常，并且其表达水平可能与抗核抗体滴度有关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the application effect of Da Vinci robot under general anesthesia in elderly abdominal surgery. Methods: The 81 patients with lung cancer who were treated in our hospital from January 2019 to June 2021 were selected as the research group, and 81 healthy volunteers who underwent physical examinations in our hospital during the same period were selected as the control group to detect and compare the peripheral blood CD4+, The ratio of CD8+ and CD4+/CD8+ lymphocytes, and the serum titer of antinuclear antibodies. Compare the ratio of CD4+, CD8+ and CD4+/CD8+ lymphocytes in peripheral blood of patients with different antinuclear antibodies, age, gender, TNM stage, tumor differentiation, and pathological types of lung cancer patients. Results: (1) The ratio of CD4+ and CD4+/CD8+ lymphocytes in peripheral blood of lung cancer patients was significantly lower than that of the control group, while the ratio of CD8+ lymphocytes was higher than that of the control group (P<0.05); (2) III+IV lung cancer patients the ratio of CD4+ and CD4+/CD8+ lymphocytes in peripheral blood was lower than that of patients with I+II lung cancer, and the ratio of CD8+ lymphocytes was higher than that of patients with I+II lung cancer (P<0.05); (3) Small The proportion of CD4+ and CD4+/CD8+ lymphocytes in peripheral blood of patients with cell lung cancer was lower than that of patients with non-small lung cancer, and the proportion of CD8+ lymphocytes was higher than that of patients with non-small lung cancer (P<0.05); (4) The serum titer of antinuclear antibodies in patients with lung cancer was higher than that in the control group (P<0.05); (5) The proportions of CD4+ and CD4+/CD8+ lymphocyte subsets in patients with positive antinuclear antibodies were lower than those in patients with negative antinuclear antibodies, and the proportion of CD8+ lymphocyte subsets was higher than that of antinuclear antibody-negative patients (P<0.05). Conclusion: The expression of T lymphocyte subsets in peripheral blood of lung cancer patients is abnormal, and the expression level may be related to antinuclear antibody titer. |
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