| 杨 倩,徐迎军,邹 洋,梁庆斌,冷富华.金振口服液联合布地奈德液雾化吸入治疗小儿急性支气管炎的疗效及对肺功能和炎症指标的影响[J].,2022,(10):1956-1959 |
| 金振口服液联合布地奈德液雾化吸入治疗小儿急性支气管炎的疗效及对肺功能和炎症指标的影响 |
| Effect of Jinzhen Oral Liquid Combined with Budesonide Atomization Inhalation on Acute Bronchitis in Children and its Effect on Pulmonary Function and Inflammatory Indexes |
| 投稿时间：2021-10-18 修订日期：2021-11-12 |
| DOI：10.13241/j.cnki.pmb.2022.10.033 |
| 中文关键词: 金振口服液 布地奈德液雾化吸入 小儿急性支气管炎 疗效 肺功能 炎症指标 |
| 英文关键词: Jinzhen oral liquid Budesonide atomization inhalation Acute bronchitis in children Efficacy Pulmonary function Inflammatory index |
| 基金项目:山东省医药卫生发展计划项目（2015WS0336） |
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| 中文摘要: |
| 摘要 目的：探讨金振口服液布联合地奈德液雾化吸入在小儿急性支气管炎中的应用价值。方法：纳入我院急诊科2020年7月-2021年7月期间收治的100例急性支气管炎患儿，根据随机数字表法分为对照组和观察组，各为50例。对照组患儿接受布地奈德液雾化吸入治疗，观察组患儿接受金振口服液联合布地奈德液雾化吸入治疗，对比两组疗效、临床症状恢复时间、肺功能[呼吸频率（RR）、潮气量（VT）、呼吸时间比（Ti/Te）、达峰时间/呼气时间（tPTEF/tE）]和炎症指标[C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、降钙素原（PCT）]，观察两组用药安全性。结果：与对照组相比，观察组的临床总有效率进一步升高（P<0.05）。与对照组相比，观察组的发热、咳嗽、肺部湿啰音症状消失时间明显缩短（P<0.05）。治疗7 d后，两组RR、Ti/Te较治疗前下降，VT、tPTEF/tE较治疗前升高，且观察组的变化幅度明显大于对照组（P<0.05）。治疗7 d后，两组CRP、TNF-α、PCT较治疗前下降，且观察组的变化幅度明显大于对照组（P<0.05）。两组在治疗期间均无相关药物不良反应发生。结论：金振口服液联合布地奈德液雾化吸入治疗小儿急性支气管炎疗效显著，可促进临床症状改善，降低机体炎性反应，改善肺功能，具有较好的临床应用价值。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the application value of budesonide atomization inhalation combined with Jinzhen oral liquid in children with acute bronchitis. Methods: 100 children with acute bronchitis who were treated in the emergency department of our hospital from July 2020 to July 2021 were selected, and they were randomly divided into control group and observation group by random number table method, with 50 cases in each group. The children in the control group were treated with budesonide liquid atomization inhalation, and the children in the observation group were treated with Jinzhen oral liquid combined with budesonide liquid atomization inhalation. The curative effect, recovery time of clinical symptoms, pulmonary function [respiratory rate (RR), tidal volume (VT), respiratory time ratio (Ti/Te), peak time / expiratory time (tPTEF/tE)] and inflammatory indexes [C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and procalcitonin (PCT)] were compared between the two groups. The drug safety of the two groups was observed. Results: Compared with the control group, the total clinical effective rate of the observation group was further increased (P<0.05). Compared with the control group, the fever, cough, disappearance time of lung wet rale symptoms of the observation group were significantly shorter (P<0.05). 7 d after treatment, RR and Ti/Te in the two groups decreased compared with before treatment, VT and tPTEF/tE increased compared with before treatment, and the change range of the observation group was significantly greater than that of the control group (P<0.05). There were no related adverse drug reactions in the two groups during the treatment. Conclusion: Jinzhen oral liquid combined with budesonide atomization inhalation in the treatment of acute bronchitis in children can promote the improvement of clinical symptoms, reduce inflammatory reactions, and improve pulmonary function, which has good clinical application value. |
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