| 田壮博,方志勇,向 斌,蔡卓言,梁帅兵.NLR联合H-FABP对Stanford B型主动脉夹层腔内修复术患者预后的预测价值[J].,2022,(10):1899-1903 |
| NLR联合H-FABP对Stanford B型主动脉夹层腔内修复术患者预后的预测价值 |
| Prognostic Value of NLR Combined with H-FABP for Prognosis of Patients Undergoing Stanford Type B Thoracic Endovascular Aneurysm Repair |
| 投稿时间：2021-11-17 修订日期：2021-12-12 |
| DOI：10.13241/j.cnki.pmb.2022.10.021 |
| 中文关键词: Stanford B型主动脉夹层 胸主动脉腔内修复术 中性粒细胞/淋巴细胞比值 心型脂肪酸结合蛋白 预后 |
| 英文关键词: Stanford type B aortic dissection Thoracic endovascular aneurysm repair Neutrophil/lymphocyte ratio Heart-type fatty acid-binding protein Prognosis |
| 基金项目:湖南省重点研发计划项目（2017SK2181） |
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| 中文摘要: |
| 摘要 目的：研究中性粒细胞/淋巴细胞比值（NLR）联合心型脂肪酸结合蛋白（H-FABP）对Stanford B型主动脉夹层胸主动脉腔内修复术（TEVAR）患者预后的预测价值。方法：选取2017年6月至2020年9月在我院接受TEVAR治疗的172例Stanford B型主动脉夹层患者为研究对象。收集所有患者基线资料、相关实验室指标水平，随访追踪患者预后，按照预后差异分作预后不良组和预后良好组，比较两组患者基线资料和实验室指标差异，采用多因素Logistic回归分析患者预后的影响因素，以受试者工作特征（ROC）曲线分析NLR联合H-FABP对患者预后的预测价值。结果：预后不良组收缩压、舒张压高于预后良好组（P＜0.05）。预后不良组NLR、H-FABP、白细胞计数（WBC）水平均高于预后良好组，而血小板计数（PLT）水平低于预后良好组（P＜0.05）。多因素Logistic回归分析显示：收缩压、舒张压、NLR、H-FABP、WBC均是Stanford B型主动脉夹层TEVAR患者预后的影响因素（P＜0.05）。ROC曲线分析显示：NLR联合H-FABP预测Stanford B型主动脉夹层TEVAR患者预后的曲线下面积为0.876均高于上述两项指标单独预测的0.626及0.712。结论：NLR联合H-FABP对Stanford B型主动脉夹层TEVAR患者预后具有一定预测价值。 |
| 英文摘要: |
| ABSTRACT Objective: To study the prognostic value of neutrophil/lymphocyte ratio (NLR) combined with heart-type fatty acid-binding protein (H-FABP) for prognosis of patients undergoing Stanford Type B thoracic endovascular aneurysm repair (TEVAR). Methods: The clinical data of 172 patients with Stanford type B aortic dissection who received TEVAR in our hospital from June 2017 to September 2020 were analyzed retrospectively. Baseline data, NLR and H-FABP levels at admission and related laboratory indicators were collected. Patients' prognosis was followed up. According to the difference in prognosis, patients were divided into poor prognosis group and good prognosis group. The above data and indicators were compared between the two groups, and the influencing factors of prognosis were analyzed by multivariate Logistic regression. Receiver operating characteristic (ROC) curve was used to analyze the prognostic value of NLR combined with H-FABP. Results: Systolic blood pressure and diastolic blood pressure in the poor prognosis group were higher than those in the good prognosis group (P＜0.05). The NLR, H-FABP and white blood cell count (WBC) levels in the poor prognosis group were higher than those in the good prognosis group, while the platelet count (PLT) level was lower than that in the good prognosis group (P＜0.05). Multivariate Logistic regression analysis showed that systolic blood pressure, diastolic blood pressure, NLR, H-FABP and WBC levels were all influencing factors for poor prognosis after TEVAR in Stanford type B aortic dissection patients (P＜0.05). ROC curve analysis showed that the area under curve of NLR combined with H-FABP in predicting the postoperative prognosis of TEVAR in Stanford type B aortic dissection patients were 0.876 which higher than those predicted by the above two indexes alone 0.626 and 0.712, respectively. Conclusion: NLR combined with H-FABP has a high prognostic value for TEVAR in Stanford type B aortic dissection patients. |
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