| 林 博,韩 冉,张万宇,苏金玲,范金辉.苓桂术甘汤对老年脾胃气虚型功能型消化不良患者胃蛋白酶原、胃泌素及血液流变学的影响[J].,2022,(10):1884-1888 |
| 苓桂术甘汤对老年脾胃气虚型功能型消化不良患者胃蛋白酶原、胃泌素及血液流变学的影响 |
| Effect of Linggui Zhugan Decoction on Pepsinogen, Gastrin and Hemorheology in Elderly Patients with Functional Dyspepsia of Deficiency of Spleen and Stomach Qi |
| 投稿时间：2021-12-02 修订日期：2021-12-26 |
| DOI：10.13241/j.cnki.pmb.2022.10.018 |
| 中文关键词: 苓桂术甘汤 脾胃气虚 功能型消化不良 老年 |
| 英文关键词: Linggui Shugan Decoction Deficiency of Qi in Spleen and Stomach Functional Dyspepsia Elderly |
| 基金项目:北京市卫计委科研基金项目（201606023）；北京中医药大学基本科研业务费基金项目（2019-JYB-JS-110） |
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| 中文摘要: |
| 摘要 目的：研究苓桂术甘汤对老年脾胃气虚型功能型消化不良患者的临床治疗效果，并探讨治疗对患者胃蛋白酶原、胃泌素和血液流变学的影响。方法：选取2020年1月到2021年10月在我院接受治疗的老年脾胃气虚型功能型消化不良患者120例，按治疗方式分为对照组以及研究组，对照组患者给予常规药物治疗，研究组患者在对照组基础上加用苓桂术甘汤进行治疗，比较两组患者临床治疗疗效和治疗前后生活质量评分、中医症候积分、血清胃蛋白酶I和II、血清胃泌素-17、血液流变学。结果：（1）研究组患者临床治疗总有效率显著高于对照组（93.33 % vs 75.00 %，P<0.05）；（2）治疗后，两组患者的生活质量评分升高，而中医症候积分降低，且研究组优于对照组（P<0.05）；（3）两组患者治疗后血胃蛋白酶I和II、血清胃泌素-17均显著降低，并且治疗后研究组低于对照组（P<0.05）；（4）两组患者治疗后血液流变学指标（高切全血黏度、低切全血黏度和血浆黏度）均显著降低，并且研究组降低程度显著高于对照组（P<0.05）。结论：加用苓桂术甘汤治疗老年脾胃气虚型功能型消化不良可显著提高临床治疗疗效，改善患者生活质量，降低患者血清胃蛋白酶原、胃泌素以及血流变学指标表达。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical therapeutic effect of Linggui Zhugan Decoction on elderly patients with functional dyspepsia due to deficiency of spleen and stomach, and to explore the effect of treatment on patients with pepsinogen, gastrin and hemorheology. Methods: A total of 120 elderly patients with functional dyspepsia of spleen-stomach-qi deficiency and functional dyspepsia who were treated in our hospital from January 2020 to October 2021 were selected and divided into a control group and a study group according to the treatment method. The patients in the control group received conventional drug treatment and the patients in the study group In addition to the treatment of patients in the control group, Lingguizhugan Decoction was used for treatment. The clinical treatment efficacy and quality of life score, TCM syndrome score, serum pepsin I and II, serum gastrin-17, and hemorheology were compared between the two groups of patients before and after treatment. Results: (1) The total effective rate of clinical treatment in the study group was significantly higher than that in the control group (93.33 % vs 75.00 %, P<0.05); (2) The quality of life scores of the two groups were significantly increased after treatment, while TCM syndrome scores were reduced, and the improvement of the quality of life scores and TCM syndrome scores of patients in the study group was better than that of the control group (P<0.05); (3) The blood pepsin I and II of the two groups of patients after treatment , Serum gastrin-17 were reduced, and after treatment, the serum pepsin I and II and serum gastrin-17 of the study group were lower than those of the control group (P<0.05); (4) The hemorheology indexes (high-cut whole blood viscosity, low-cut whole blood viscosity and plasma viscosity) of the two groups of patients were reduced after treatment, and the degree of reduction in the study group was significantly higher than that in the control group (P<0.05). Conclusion: The addition of Linggui Zhugan Decoction in the treatment of senile functional dyspepsia of spleen and stomach qi deficiency can significantly improve the clinical therapeutic effect, improve the quality of life of patients, and reduce the expression of serum pepsinogen, gastrin and hemorheology. |
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