| 郑慧媛,马新春,张 英,李建民,宋 凡.血清嗜酸性粒细胞表达水平与鼻腔鼻窦内翻性乳头状瘤病理的相关性分析[J].,2022,(8):1591-1595 |
| 血清嗜酸性粒细胞表达水平与鼻腔鼻窦内翻性乳头状瘤病理的相关性分析 |
| Correlation between the Expression of Eosinophils in Serum and the Pathology of Inverted Papilloma of Nasal Cavity and Paranasal Sinuses |
| 投稿时间：2021-08-23 修订日期：2021-09-17 |
| DOI：10.13241/j.cnki.pmb.2022.08.040 |
| 中文关键词: 嗜酸性粒细胞 鼻腔鼻窦内翻性乳头状瘤 临床分期 病理诊断 |
| 英文关键词: Eosinophils Inverted papilloma of nasal cavity and paranasal sinuses Clinical stage Pathological diagnosis |
| 基金项目:青海省卫生计生委重点项目（2018-wjzd-11） |
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| 中文摘要: |
| 摘要 目的：探讨血清嗜酸性粒细胞（EOS）表达水平与鼻腔鼻窦内翻性乳头状瘤（SNIP）病理的相关性。方法：选取我院2016年1月至2020年1月收治的63例SNIP患者作为研究对象，依照所有患者EOS水平将其分为低EOS组、中EOS组、高EOS组，对比三组患者的临床病理特征，并分析EOS表达水平与SNIP病理的相关性。行手术治疗后将63例患者分为预后不良组与预后良好组，对比两组患者的临床相关指标，并分析EOS表达水平对SNIP的预后预测价值。结果：三组患者临床分期、病理诊断对比差异显著（P＜0.05）；以EOS表达水平进行分级：高水平：＞300个/μL，中水平：100-300个/μL，低水平：＜100个/μL。Spearman相关分析结果显示：性别、年龄、病灶位置与EOS表达水平无明显相关性（P＞0.05），临床分期、病理诊断与EOS水平呈负相关（P＜0.05）；预后良好组与预后不良组患者PLT水平对比无明显差异（P＞0.05），预后两组患者L、EOS水平明显高于预后不良组，N、PLR、NLR低于预后不良组（P＜0.05）；logistic回归分析结果表明：NLR、EOS为SNIP的预后独立预测因素（P＜0.05）。结论：SNIP患者的临床分期、病理诊断与EOS表达水平呈负相关，且应用NLR和EOS可对SNIP术后复发情况进行预测，因此，可以考虑应用EOS表达水平对SNIP进行诊断与治疗效果判定。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between serum eosinophil (EOS) expression level and pathology of inverted papilloma in nasal cavity and sinuses (SNIP). Methods: 63 cases of patients with SNIP admitted to our hospital from January 2016 to January 2020 were selected as the research objects. According to the EOS level of all patients, they were divided into low EOS group, medium EOS group and high EOS group. The clinicopathological characteristics of the three groups were compared, and the correlation between EOS expression level and SNIP pathology was analyzed. After surgical treatment, 63 patients were divided into poor prognosis group and good prognosis group. The clinical related indexes of the two groups were compared, and the prognostic value of EOS expression level in SNIP was analyzed. Results: There was significant difference in clinical stage and pathological diagnosis among the three groups(P<0.05); According to the expression level of EOS, there were more than 300 eosinophils at high level/μL. Medium level: 100-300/μL. Low level:<100/μL. Spearman correlation analysis showed that there was no significant correlation between the expression level of the gender, age, lesion location and EOS (P>0.05), but negative correlation between the expression level of the clinical stage and pathological diagnosis and EOS (P<0.05); There was no significant difference in PLT between the two groups (P>0.05). The levels of L and EOS in the two groups were significantly higher than those in the poor prognosis group, and the levels of N, PLR and NLR in the two groups were lower than those in the poor prognosis group (P<0.05); Logistic regression analysis showed that NLR and EOS were independent prognostic factors of SNIP (P<0.05). Conclusion: The clinical stage and SNIP are negatively correlated with the expression level of EOS, and the application of NLR and EOS can predict the recurrence of SNIP. Therefore, the expression level of EOS can be considered to determine the diagnosis and treatment effect of SNIP. |
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