| 苏 菁,杨雅婷,贾聚娟,项保利,钱海红,支学军,李 琛,赵建清,冯亚娆.涎液化糖链抗原、基质金属蛋白酶-7和透明质酸联合诊断结缔组织病合并间质性肺疾病的临床价值[J].,2022,(8):1534-1538 |
| 涎液化糖链抗原、基质金属蛋白酶-7和透明质酸联合诊断结缔组织病合并间质性肺疾病的临床价值 |
| Clinical Value of Joint Diagnosis of Connective Tissue Disease Combined with Interstitial Lung Disease with Krebs Von Den Lungen-6, Matrix Metalloproteinase-7 and Hyaluronic Acid |
| 投稿时间：2021-09-05 修订日期：2021-09-27 |
| DOI：10.13241/j.cnki.pmb.2022.08.028 |
| 中文关键词: 涎液化糖链抗原 基质金属蛋白酶-7 透明质酸 结缔组织病 间质性肺疾病 诊断价值 |
| 英文关键词: Krebs von den lungen-6 Matrix metalloproteinase-7 Hyaluronic acid Connective tissue disease Interstitial lung disease Diagnosis value |
| 基金项目:河北省张家口市科技攻关计划项目（1921051D）；河北省重点课题计划项目（20160366） |
|
| 摘要点击次数: 498 |
| 全文下载次数: 217 |
| 中文摘要: |
| 摘要 目的：探讨涎液化糖链抗原（KL-6）、基质金属蛋白酶-7（MMP-7）和透明质酸（HA）联合诊断结缔组织病合并间质性肺疾病（ILD）的价值。方法：选取2017年12月至2019年12月本院收治的69例结缔组织病合并ILD患者作为本文研究对象（合并ILD组），以单纯结缔组织病患者67例，同期体检的60例健康受试者分别作为单纯结缔组织病组和对照组。比较三组受试者血清KL-6、MMP-7和HA，Logistic回归分析确定结缔组织病发生ILD的独立影响因素，通过受试者工作特征（ROC）曲线分析诊断效能。结果：三组血清KL-6、MMP-7和HA水平有差异（P<0.05），合并ILD组患者血清KL-6、MMP-7和HA水平明显高于单纯结缔组织病组和对照组（P<0.05），单纯结缔组织病组患者血清KL-6、MMP-7和HA水平明显高于对照组（P<0.05）。Logistic回归分析结果表明，血清KL-6、MMP-7、HA等三指标及粉尘接触史均是结缔组织病发生ILD的显著影响因素（P<0.05）。 ROC分析显示： 血清KL-6、MMP-7和HA等三指标诊断结缔组织病发生ILD的AUC（0.95CI）分别为0.715（0.439～0.988）、0.702（0.440～0.959）、0.711（0.500～0.919），三指标联合应用的AUC（0.95CI）为0.811（0.705～0.913），诊断效能较高。结论：结缔组织病合并ILD患者血清KL-6、MMP-7及HA升高，联合应用诊断可提高对ILD的诊断效能，为早期诊断ILD提供一定的参考。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the value of joint diagnosis of connective tissue disease combined with interstitial lung disease (ILD) with krebs von den lungen-6 (KL-6), matrix metalloproteinase-7 (MMP-7) and hyaluronic acid (HA). Methods: A total of 69 patients with connective tissue disease combined with ILD treated in our hospital from December 2017 to December 2019 were selected as the research object (combined ILD group), 67 patients with simple connective tissue disease and 60 healthy subjects who underwent physical examination in the same period were selected as the simple connective tissue disease group and the control group respectively. The serum KL-6, MMP-7 and HA of the three groups were compared, logistic regression analysis was used to determine the independent influencing factors of ILD in connective tissue disease, receiver operating characteristic (ROC) curve was used to analyze the diagnostic efficacy. Results: There was statistical significant difference in the levels of serum KL-6, MMP-7 and HA among the three groups (P<0.05), the levels of serum KL-6, MMP-7 and HA in the combined ILD group were significantly higher than those in the simple connective tissue disease group and the control group (P<0.05), the levels of serum KL-6, MMP-7 and HA in the simple connective tissue disease group were significantly higher than those in the control group(P<0.05). Logistic regression analysis showed that serum KL-6,MMP-7, HA and dust exposure history were significant influencing factors of ILD in connective tissue disease(P<0.05). ROC curve analysis showed that the AUC（95%CI） of serum KL-6, MMP-7 and HA for ILD in connective tissue disease were 0.715(0.439~0.988), 0.702(0.440~0.959), 0.711(0.500~0.919) respectively, the AUC(95%CI) of the joint detection of the above three indexes was 0.811(0.705~0.913), which meant higher diagnostic efficiency. Conclusion: The levels of serum KL-6, MMP-7 and HA in patients with connective tissue disease combined with ILD increase, the joint diagnosis can improve the diagnostic efficiency of connective tissue disease combined with ILD, and provide some references for early diagnosis of ILD. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
