| 徐 帅,张 振,张喜平,白雪峰,白海珍.三阴乳腺癌新辅助化疗的预后与Ki-67、TOPK的表达情况相关性研究[J].,2022,(8):1514-1518 |
| 三阴乳腺癌新辅助化疗的预后与Ki-67、TOPK的表达情况相关性研究 |
| Study of Correlation of Ki-67, TOPK Expression of Neoadjuvant Chemotherapy in Triple-negative Breast Cancer with Prognosis |
| 投稿时间：2021-09-06 修订日期：2021-09-29 |
| DOI：10.13241/j.cnki.pmb.2022.08.024 |
| 中文关键词: 三阴乳腺癌 新辅助化疗 Ki-67 TOPK |
| 英文关键词: Triple-negative breast cancer Neoadjuvant chemotherapy Ki-67 TOPK |
| 基金项目:内蒙古自治区科技计划项目（201602097） |
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| 中文摘要: |
| 摘要 目的：研究三阴乳腺癌（TNBC）新辅助化疗（NACT）的预后与Ki-67、TOPK的表达情况的相关性。方法：回顾性收集2014年3月至2016年6月期间我院收治并行NACT的TNBC患者90例作为研究对象，免疫组化法检测肿瘤组织中Ki-67和TOPK的表达，分析两者的表达与患者临床资料的关系，应用COX回归模型进行生存分析，分析影响TNBC患者预后的独立危险因素。结果：在治疗情况方面，91.11 %（82/90）的患者接受了≥4个周期的NACT治疗，84.44 %（76/90）的患者接受了手术治疗，术后pCR为22.22 %（20/90），ORR为75.56 %（68/90）。为期5年的随访中，90例患者中共死亡8例（死于TNBC者6例，其他原因2例），失访2例；治疗后Ki-67和TOPK的阳性率均显著低于治疗前（P＜0.05）；Ki-67、TOPK阳性和阴性表达病例在不同TNM分期、淋巴结是否转移上具有显著性差异（P＜0.05）；Ki-67和TOPK阳性表达患者的无进展生存期（PFS）和总生存期（OS）显著短于阴性表达者（P＜0.05）；TNM分期、淋巴结转移、Ki-67和TOPK阳性表达均为影响TNBC患者预后的独立危险因素。结论：Ki-67和TOPK在TNBC组织中的表达与患者的病理学特征及预后密切相关，是影响预后的独立危险因素。 |
| 英文摘要: |
| ABSTRACT Objective: To analysis the correlation of Ki-67, TOPK expression of neoadjuvant chemotherapy(NACT) in triple-negative breast cancer(TNBC) with prognosis. Methods: 90 TNBC patients admitted in our hospital from March 2014 to June 2016 were collected as research objects, the expression of Ki-67 and TOPK in tumor tissues were detected by immunohistochemistry method, the correlation of Ki-67 and TOPK expression with pathological characteristics were analysed, the survival analysis were analyzed by Cox proportional hazards regression model rognosis, the independent risk factors for prognosis were analysed. Results: In terms of treatment, 91.11 % (82/90) of patients received ≥4 cycles of NACT, 84.44 %(76/90) of patients received surgery, and post-operative pCR was 22.22 % (20/90) and ORR was 75.56 % (68/90). During the 5-year follow-up, 8 of the 90 patients died (6 died of TNBC and 2 died of other causes), and 2 were lost to follow-up. The positive expression rates of Ki-67 and TOPK were decreased after NACT(P＜0.05). There were significant differences between the positive and negative expression of KI-67 and TOPK in different TNM stages and lymph node metastasis (P＜0.05). The progression-free survival (PFS) and overall survival (OS) of patients with Ki-67 and TOPK positive expression was shorter than negative expression (P＜0.05). The prognosis of TNBC patients were independently associated with TNM stage, lymph node metastasis, positive expression of Ki-67 and TOPK(P＜0.05). Conclusion: The expression of Ki-67 and TOPK in tissues was closely correlated with pathological characteristics and prognosis, which were independent risk fators for prognosis. |
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