| 陈 静,秦 诺,张站站,韦 红,王永明.枸橼酸咖啡因联合正压通气对新生儿呼吸窘迫患儿铁蛋白及Clara细胞分泌蛋白的影响[J].,2022,(7):1357-1361 |
| 枸橼酸咖啡因联合正压通气对新生儿呼吸窘迫患儿铁蛋白及Clara细胞分泌蛋白的影响 |
| Effect of Caffeine Citrate Combined with Positive Pressure Ventilation on Ferritin and Clara Cell Secretory Protein in Neonatal Respiratory Distress |
| 投稿时间：2021-07-24 修订日期：2021-08-20 |
| DOI：10.13241/j.cnki.pmb.2022.07.034 |
| 中文关键词: 枸橼酸咖啡因 无创正压通气 护理窘迫 新生儿 铁蛋白 Clara细胞分泌蛋白 |
| 英文关键词: Caffeine citrate Noninvasive positive pressure ventilation Nursing distress Newborn ferritin Clara cell secretory protein |
| 基金项目:重庆市卫健委临床重点专科专项基金（2018-61） |
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| 中文摘要: |
| 摘要 目的：探讨枸橼酸咖啡因联合正压通气对新生儿呼吸窘迫患儿铁蛋白及Clara细胞分泌蛋白的影响。方法：选取我院2016年1月到2021年1月共收治的82例新生儿呼吸窘迫患儿作为研究对象，所有患儿均需要机械通气治疗，将所有患儿随机分为观察组与对照组，每组41例。对照组患儿应用无创正压通气治疗，对照组患儿应用枸橼酸咖啡因联合无创正压通气治疗，对比两组患儿的住院时间、给氧时间和机械通气时间，治疗前后的呼吸功能指标与血气指标，治疗前后的SF、CC16表达水平以及两组患儿治疗过程中出现的用药不良反应和并发症情况。结果：观察组患儿的住院时间、给氧时间、机械通气时间明显低于对照组，组间对比，差异具有统计学意义（P＜0.05）；两组患儿治疗前P/F值、PaO2、PaCO2和pH值表达水平对比无明显差异（P＞0.05），治疗24 h后，两组患儿pH值对比无明显差异（P＞0.05），与对照组相比，观察组P/F值、PaO2水平显著升高，PaCO2水平显著降低（P＜0.05）；两组患儿治疗前SF、CC16水平对比无明显差异（P＞0.05），治疗后两组患者SF、CC16表达水平均降低，且观察组显著低于对照组（P＞0.05）；观察组患儿并发症及不良反应发生总计11例，发生率为26.83，显著低于对照组的22例（53.66%）（P＜0.05）。结论：枸橼酸咖啡因联合正压通气比单一正压通气治疗新生儿呼吸窘迫效果更好，能够缩短患儿的住院时间和通气时间，减轻家属压力，同时能够提升患儿的氧合效率和血气指标，改善铁蛋白及Clara细胞分泌蛋白水平，降低并发症发生率，安全性好，值得临床应用推广。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of caffeine citrate combined with positive pressure ventilation on ferritin and Clara cell secretory protein in neonatal respiratory distress. Methods: 82 cases of neonatal respiratory distress in our hospital from January 2016 to January 2021 were selected as the research object, all children need mechanical ventilation treatment, all children were randomly divided into observation group and control group, 41 cases in each group. The control group was treated with noninvasive positive pressure ventilation, and the control group was treated with caffeine citrate combined with noninvasive positive pressure ventilation. The hospitalization time, oxygen supply time and mechanical ventilation time, respiratory function index and blood gas index before and after treatment, SF and SF before and after treatment were compared between the two groups The expression level of CC16 and the adverse drug reactions and complications of the two groups during treatment. Results: The hospitalization time, oxygen time and mechanical ventilation time of the observation group were significantly lower than those of the control group (P<0.05); There was no significant difference in the expression levels of P / F value, PaO2, PaCO2 and pH value between the two groups before treatment (P>0.05). After 24 hours of treatment, there was no significant difference in the pH value between the two groups (P>0.05). Compared with the control group, the P/F value and PaO2 level of the observation group increased significantly, and the PaCO2 level decreased significantly(P＜0.05); There was no significant difference in the expression levels of SF and CC16 between the two groups before treatment (P>0.05). After treatment, the levels of SF and CC16 in the two groups were decreased, and the observation group was significantly lower than the control group(P>0.05); A total of 11 cases of complications and adverse reactions occurred in the observation group, the incidence was 26.83, which was significantly lower than the 22 cases (53.66%) in the control group (P＜0.05). Conclusion: Caffeine citrate combined with positive pressure ventilation is better than single positive pressure ventilation in the treatment of neonatal respiratory distress, which can shorten the hospitalization time and ventilation time, reduce the pressure of family members, improve the oxygenation efficiency and blood gas index, improve the level of ferritin and Clara cell secreted protein, reduce the incidence of complications, and has good safety, It is worthy of clinical application and promotion. |
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