| 刘宏超,孙京华,蒋甘孺,王 敏,尹忠诚.海昆肾喜胶囊联合包醛氧淀粉对慢性肾功能衰竭患者肾功能、炎症因子和生命质量的影响[J].,2022,(6):1197-1200 |
| 海昆肾喜胶囊联合包醛氧淀粉对慢性肾功能衰竭患者肾功能、炎症因子和生命质量的影响 |
| Effects of Haikun Shenxi Capsule Combined with Coated Aldehyde Oxystarch on Renal Function, Inflammatory Factors and Quality of Life in Patients with Chronic Renal Failure |
| 投稿时间：2021-11-22 修订日期：2021-12-16 |
| DOI：10.13241/j.cnki.pmb.2022.06.041 |
| 中文关键词: 海昆肾喜胶囊 包醛氧淀粉 慢性肾功能衰竭 肾功能 炎症因子 生命质量 |
| 英文关键词: Haikun Shenxi capsule Coated aldehyde oxystarch Chronic renal failure Renal function Inflammatory factors Quality of life |
| 基金项目:江苏省卫生厅医学科技发展基金项目（H200833） |
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| 中文摘要: |
| 摘要 目的：观察海昆肾喜胶囊联合包醛氧淀粉对慢性肾功能衰竭（CRF）患者肾功能、炎症因子和生命质量的影响。方法：选择2019年 5月 ~2021年 4月期间我院收治的 93例 CRF患者，根据双色球随机分组法将患者分为对照组（46例）和研究组（47例）。对照组接受包醛氧淀粉治疗，研究组接受海昆肾喜胶囊联合包醛氧淀粉治疗。观察两组疗效和用药安全性。对比两组肾功能、炎症因子、生命质量变化。结果：研究组的临床总有效率比对照组高（P<0.05）。治疗 8周后，两组患者的血肌酐（Scr）、尿素氮（BUN）、β2-微球蛋白（β2-MG）水平降低，且研究组低于对照组；两组患者的白蛋白（ALB）水平升高，且研究组高于对照组（P<0.05）。治疗8周后，两组患者的肿瘤坏死因子 -α（TNF-α）、白细胞介素 -6（IL-6）、超敏 C反应蛋白（hs-CRP）水平降低，且研究组低于对照组（P<0.05）。治疗 8周后，两组慢性肾衰竭生命质量量表（QLICD-CRF 2.0）各项目（生理功能、心理功能、社会功能、特异性模块）评分升高，且研究组高于对照组（P<0.05）。两组不良反应发生率比较无差异（P>0.05）。结论：海昆肾喜胶囊联合包醛氧淀粉治疗可有效改善 CRF患者肾功能，减轻机体炎症反应，改善患者生命质量。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of Haikun Shenxi capsule combined with coated aldehyde oxystarch on renal function, inflammatory factors and quality of life in patients with chronic renal failure (CRF). Methods: 93 patients with CRF who were treated in our hospital from May 2019 to April 2021 were selected. According to the two-color ball scheme, the patients were divided into control group (46 cases) and study group (47 cases). The control group was treated with coated aldehyde oxystarch, and the study group was treated with Haikun Shenxi capsule combined with coated aldehyde oxystarch. The efficacy and medication safety of the two groups were observed. The changes of renal function, inflammatory factors and quality of life were compared between the two groups. Results: The total clinical effective rate of the study group was higher than that of the control group(P<0.05). 8 weeks after treatment, the levels of serum creatinine(Scr), urea nitrogen (BUN) andβ2-microglobulin（β2-MG) in both groups were decreased, and the study group was lower than the control group. The level of albumin (ALB) in the two groups was increased, and the study group was higher than the control group (P<0.05). 8 weeks after treatment, the levels of tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6) and hypersensitive C-reactive protein (hs-CRP) in both groups were decreased, and study group was lower than control group (P<0.05). 8 weeks after treatment, the scores of various items (physiological function, psychological function, social function and specific module) of chronic renal failure quality of Life Scale(QLICD-CRF2.0) in the study group were increased, and the study group was higher than the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Haikun Shenxi capsule combined with coated aldehyde oxystarch can effectively improve the renal function of patients with CRF, reduce the inflammatory response of the body, and improve the quality of life of patients. |
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