文章摘要
谭 宜,高 华,郭杨超,吴 波,阿不都沙拉木·阿不都,艾热提·吾杰克.结直肠癌组织AGR2、MFAP2蛋白表达与临床病理特征和预后的关系研究[J].,2022,(6):1116-1120
结直肠癌组织AGR2、MFAP2蛋白表达与临床病理特征和预后的关系研究
Study on the Relationship between AGR2, MFAP2 Protein Expression and Clinicopathological Features and Prognosis of Colorectal Cancer
投稿时间:2021-07-23  修订日期:2021-08-19
DOI:10.13241/j.cnki.pmb.2022.06.025
中文关键词: 结直肠癌  前梯度蛋白2  微纤维相关蛋白2  临床病理特征  预测
英文关键词: Colorectal cancer  Pregradient protein 2  Microfiber associated protein 2  Clinicopathological features  Prognosis
基金项目:新疆维吾尔自治区卫生健康青年医学科技人才专项科研项目(WJWY-202149)
作者单位E-mail
谭 宜 新疆医科大学第一附属医院胃肠(肿瘤)外科 新疆 乌鲁木齐 830000 ty841398039@163.com 
高 华 新疆医科大学第一附属医院胃肠(肿瘤)外科 新疆 乌鲁木齐 830000  
郭杨超 新疆医科大学第一附属医院胃肠(肿瘤)外科 新疆 乌鲁木齐 830000  
吴 波 新疆医科大学第一附属医院胃肠(肿瘤)外科 新疆 乌鲁木齐 830000  
阿不都沙拉木·阿不都 新疆医科大学第一附属医院胃肠(肿瘤)外科 新疆 乌鲁木齐 830000  
艾热提·吾杰克 新疆医科大学第一附属医院胃肠(肿瘤)外科 新疆 乌鲁木齐 830000  
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中文摘要:
      摘要 目的:研究结直肠癌(CRC)组织前梯度蛋白2(AGR2)、微纤维相关蛋白2(MFAP2)蛋白表达与临床病理特征和预后的关系。方法:将我院从2015年1月~2016年2月收治的84例CRC患者纳入研究。分别采集所有患者的CRC组织以及癌旁正常组织(距离肿瘤边缘2~5 cm),检测并比较不同组织中AGR2、MFAP2蛋白表达情况。分析AGR2、MFAP2蛋白表达与CRC患者临床病理特征以及预后的关系。采用Cox回归模型分析CRC患者预后的影响因素。结果:CRC组织中AGR2、MFAP2蛋白阳性表达率均高于癌旁正常组织(P<0.05)。分化程度为低分化、TNM分期为Ⅲ期及脉管浸润的CRC患者的AGR2、MFAP2蛋白阳性表达率均高于分化程度为中高分化、TNM分期为Ⅰ~Ⅱ期、无脉管浸润的CRC患者(P<0.05)。AGR2、MFAP2蛋白阳性表达患者的3年生存率及5年生存率均明显低于阴性表达患者(P<0.05)。经Cox回归模型分析发现:分化程度为低分化、TNM分期为Ⅲ期、脉管浸润以及AGR2、MFAP2蛋白阳性表达均是CRC患者死亡的危险因素(P<0.05)。结论:CRC组织中AGR2、MFAP2蛋白阳性表达率升高,且和患者分化程度、TNM分期、脉管浸润有关,检测其表达情况有助于预测CRC患者预后。
英文摘要:
      ABSTRACT Objective: To study the relationship between the tissue pregradient protein 2 (AGR2) and microfiber associated protein 2 (MFAP2) protein 2expression and clinicopathological features and prognosis of colorectal cancer (CRC). Methods: 84 patients with CRC who were admitted to the hospital from January 2015 to February 2016 were included in the study. CRC tissues and adjacent normal tissues (2 ~ 5cm away from the tumor edge) were collected from all patients, and the AGR2 and MFAP2 protein expression in different tissues were detected and compared. The relationship between AGR2, MFAP2 protein expression and clinicopathological features and prognosis of patients with CRC were analyzed. Cox regression model was used to analyze the prognostic factors of patients with CRC. Results: The positive expression rates of AGR2 and MFAP2 protein in CRC tissues were all higher than those in adjacent normal tissues(P<0.05). The positive expression rates of AGR2 and MFAP2 protein in patients with CRC with low differentiation, TNM stage was Ⅲ and vascular invasion were higher than those in patients with CRC with medium and high differentiation, TNM stage was Ⅰ~Ⅱ, and no vascular invasion(P<0.05). 3-year survival rate and 5-year survival rate in AGR2, MFAP2 protein positive patients were significantly lower than those with negative expression patients(P<0.05). Cox regression model analysis showed that the degree of differentiation was low, TNM stage was stage III, vascular infiltration and the positive expression of AGR2 and MFAP2 protein were the risk factors of death in patients with CRC(P<0.05). Conclusion: The positive expression rate of AGR2 and MFAP2 protein in CRC increased, which are related to the degree of differentiation, TNM stage and vascular infiltration of patients. Detecting their expression is helpful to predict the prognosis of patients with CRC.
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