| 王朝辉,唐 娜,封 彬,王慧娟,王亚欣.丹参川芎嗪注射液联合乌司他丁对重症急性胰腺炎患者血清炎症因子、细胞免疫功能及生活质量的影响[J].,2022,(5):876-880 |
| 丹参川芎嗪注射液联合乌司他丁对重症急性胰腺炎患者血清炎症因子、细胞免疫功能及生活质量的影响 |
| Effect of Salvia Miltiorrhiza Ligustrazine Injection Combined with Ulinastatin on Serum Inflammatory Factors, Cellular Immune Function and Quality of Life in Patients with Severe Acute Pancreatitis |
| 投稿时间：2021-07-23 修订日期：2021-08-18 |
| DOI：10.13241/j.cnki.pmb.2022.05.016 |
| 中文关键词: 丹参川芎嗪注射液 乌司他丁 重症急性胰腺炎 炎症因子 细胞免疫功能 生活质量 |
| 英文关键词: Salvia miltiorrhiza ligustrazine injection Ulinastatin Severe acute pancreatitis Inflammatory factors Cellular immune function Quality of life |
| 基金项目:北京市卫计委科研项目(2015055) |
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| 中文摘要: |
| 摘要 目的：探讨丹参川芎嗪注射液联合乌司他丁对重症急性胰腺炎（SAP）患者血清炎症因子、细胞免疫功能及生活质量的影响。方法：本次研究为前瞻性研究，选取2017年8月~2020年6月期间我院收治的SAP患者120例，根据信封抽签法将患者分为对照组（乌司他丁治疗）和实验组（对照组的基础上联合丹参川芎嗪注射液治疗），各为60例。对比两组疗效、临床症状改善时间及住院时间、血清炎症因子、细胞免疫功能及生活质量，记录两组不良反应情况、外科手术率及病死率。结果：实验组治疗2周后的总有效率高于对照组（P<0.05）。两组治疗2周后血清C反应蛋白（CRP）、白介素-6（IL-6）及肿瘤坏死因子-α（TNF-α）水平均较治疗前下降，且实验组低于对照组（P<0.05）。两组治疗2周后CD8+较治疗前下降，且实验组低于对照组（P<0.05），CD3+、CD4+、CD4+/CD8+较治疗前升高，且实验组高于对照组（P<0.05）。两组治疗2周后生理职能、社会功能、情感职能、躯体疼痛、生理机能、活力、精神健康、健康状况评分较治疗前升高，且实验组高于对照组（P<0.05）。实验组血淀粉酶恢复正常时间、肠鸣音恢复时间、住院时间、排气恢复时间、腹胀腹痛消除时间较对照组更短（P<0.05）。两组不良反应发生率、外科手术率、病死率对比组间无差异（P>0.05）。结论：丹参川芎嗪注射液联合乌司他丁治疗SAP患者，可促进症状改善，降低炎症因子水平，改善患者免疫功能及生活质量，安全有效。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Salvia miltiorrhiza ligustrazine injection combined with ulinastatin on serum inflammatory factors, cellular immune function and quality of life in patients with severe acute pancreatitis (SAP). Methods: This study was a prospective study. 120 patients with SAP in our hospital from August 2017 to June 2020 were selected, and they were divided into control group (ulinastatin) and experimental group (Salvia miltiorrhiza and ligustrazine injection on the basis of the control group) according to the drawing method, with 60 cases in each group. The efficacy, clinical indicators, serum inflammatory factors, cellular immune function and quality of life of the two groups were compared, and adverse reactions, surgical operation rate and mortality of the two groups were recorded. Results: The total effective rate of the experimental group was higher than that of the control group at 2 weeks after treatment (P<0.05). 2 weeks after treatment, the serum levels of C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the two groups were decreased compared with those before treatment, and the experimental group was lower than the control group(P<0.05). 2 weeks after treatment, CD8+ decreased in the two groups, and the experimental group was lower than the control group(P<0.05), while CD3+, CD4+, CD4+/CD8+ were higher than before treatment, and the experimental group was higher than the control group(P<0.05). 2 weeks after treatment, the scores of physiological function, social function, emotional function, physical pain, physiological enginery, vitality, mental health, health status in the two groups were higher than those before treatment, and the experimental group was higher than the control group(P<0.05). The blood amylase recovery time, recovery time of bowel sounds, hospitalization time, exhaust recovery time, abdominal distension and abdominal pain elimination time of the experimental group were shorter than those of the control group(P<0.05). There were no difference in the incidence of adverse reactions, surgical operation rate and mortality between the two groups(P>0.05). Conclusion: Salvia miltiorrhiza ligustrazine injection combined with ulinastatin in the treatment of patients with SAP, can promote the improvement of symptoms, reduce the level of inflammatory factors, improve the immune function and quality of life of patients, safe and effective. |
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