| 姚文浩,夏志楠,张大明,张 诚.肾透明细胞癌中免疫检查点相关的免疫逃逸机制的研究进展[J].,2022,(4):796-800 |
| 肾透明细胞癌中免疫检查点相关的免疫逃逸机制的研究进展 |
| Research Progress of Immune Escape Mechanism Related to Immune Checkpoint in Renal Clear Cell Carcinoma |
| 投稿时间：2021-09-23 修订日期：2021-10-18 |
| DOI：10.13241/j.cnki.pmb.2022.04.041 |
| 中文关键词: 肾透明细胞癌 免疫检查点 免疫逃逸 |
| 英文关键词: Renal clear cell carcinoma Immune checkpoint Immune escape |
| 基金项目:国家自然科学基金项目（81872084） |
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| 中文摘要: |
| 摘要：近年来，免疫治疗在晚期肾透明细胞癌的治疗中异军突起，使人们对于肾癌治疗有了全新的认识。肿瘤免疫治疗药物是通过抑制免疫检查点从而抑制肿瘤细胞免疫逃逸，使免疫细胞可以杀伤肿瘤细胞来发挥治疗作用。因此，了解肾透明细胞癌中免疫检查点相关免疫逃逸机制对于制定有效的治疗策略以及开发新的免疫治疗药物至关重要。本文对目前肾透明细胞癌中主要的免疫检查点（PD-1/PD-L1、CTLA-4、B7-H4、LAG-3、TIM-3和HLA-G）相关的免疫逃逸机制进行综述。 |
| 英文摘要: |
| ABSTRACT: In recent years, immunotherapy has sprung up in the treatment of advanced renal clear cell carcinoma, giving people a new understanding of tumor treatment. The mechanism of these immunotherapy drugs is to inhibit the immune escape of tumor cells by suppressing immune checkpoints, so that the immune cells could kill tumor cells to play a therapeutic role. Therefore, understanding the immune escape mechanism related to immune checkpoints in renal clear cell carcinoma is essential for formulating effective treatment strategies and developing new immunotherapy drugs. This article reviews the immune escape mechanisms related to the main immune checkpoints (PD-1/PD-L1, CTLA-4, B7-H4, LAG-3, TIM-3 and HLA-G) in renal clear cell cancer. |
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