| 沈柏宇,杨丽芬,刘 娟,代智敏,吴 珂.明目羊肝丸联合普拉洛芬滴眼液治疗围绝经期干眼症的临床研究[J].,2022,(3):553-556 |
| 明目羊肝丸联合普拉洛芬滴眼液治疗围绝经期干眼症的临床研究 |
| Clinical study of Mingmu Yanggan Pill Combined with Pranoprofen Eye Drops in the Treatment of Perimenopausal Dry Eye |
| 投稿时间：2021-05-06 修订日期：2021-05-30 |
| DOI：10.13241/j.cnki.pmb.2022.03.032 |
| 中文关键词: 明目羊肝丸 普拉洛芬滴眼液 围绝经期 干眼症 疗效 |
| 英文关键词: Mingmu Yanggan pill Pranoprofen eye drops Perimenopausal Dry eye Efficacy |
| 基金项目:贵州省卫生计生委科学技术基金项目（gzwjkj2017-1-076） |
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| 中文摘要: |
| 摘要 目的：探讨明目羊肝丸联合普拉洛芬滴眼液治疗围绝经期干眼症的临床疗效。方法：选取2019年7月至2020年8月在我院就诊的围绝经期干眼症患者103例206眼，根据随机数字表法将患者分为对照组（普拉洛芬滴眼液治疗）和实验组（对照组的基础上联合明目羊肝丸治疗），分别为51例102眼和52例104眼，两组均治疗2个月。对比两组疗效、症状评分、泪液炎症因子、生存质量、Schirmer I试验（SIT）、泪膜破裂时间（BUT）、角膜荧光素染色（FL）评分及不良反应。结果：实验组治疗2个月后的临床总有效率优于对照组（P<0.05）。治疗2个月后，实验组眼干涩、视疲劳、异物感、灼热感症状评分、FL评分低于对照组（P<0.05）。治疗2个月后，实验组BUT、SIT高于对照组（P<0.05）。治疗2个月后，实验组泪液白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平低于对照组（P<0.05）。治疗2个月后，实验组心理健康、眼痛、社会活动、一般健康评分高于对照组（P<0.05）。两组治疗过程中均无明显不良反应。结论：明目羊肝丸联合普拉洛芬滴眼液治疗围绝经期干眼症，可改善患者症状和泪膜稳定性，降低泪液炎症因子水平，提高患者生存质量，安全有效。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical efficacy of Mingmu Yanggan pill combined with pralofene eye drops in the treatment of perimenopausal dry eye. Methods: 103 cases with 206 eyes of perimenopausal dry eye patients in our hospital from July 2019 to August 2020 were selected. According to the random number table method, the patients were divided into the control group (treated with pranoprofen eye drops) and the experimental group (treated with Mingmu Yanggan pill on the basis of the control group) 51 cases with 102 eyes and 52 cases with 104 eyes respectively. The two groups were treated for 2 months. The efficacy, symptom score, tear inflammatory factors, quality of life, Schirmer I test (SIT), tear film break-up time (BUT), corneal fluorescein staining (FL) score and adverse reactions were compared between the two groups. Results: The total effective rate of the experimental group at 2 months after treatment was better than that of the control group(P<0.05). 2 months after treatment, the dry eye, asthenopia, foreign body sensation, burning symptom score and FL score of the experimental group were lower than those of the control group(P<0.05). 2 months after treatment, BUT and SIT of the experimental group were higher than those of the control group(P<0.05). 2 months after treatment, the levels of interleukin-6(IL-6), tumor necrosis factor-α(TNF-α) in tears of the experimental group were lower than those of the control group (P<0.05). 2 months after treatment, the scores of mental health, eye pain, social activities and general health of the experimental group were higher than those of the control group(P<0.05). There was no obvious discomfort in the two groups during treatment. Conclusion: Mingmu Yanggan pill combined with pranoprofen eye drops in the treatment of perimenopausal dry eye can improve the symptoms of patients and tear film stability, reduce the level of inflammatory factors in tears, improve the quality of life of patients, which is safe and effective. |
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