| 方丽兰,余更生,庞景灼,关婉贤,廖月华,陈嘉骥.非小细胞肺癌患者外周血循环肿瘤细胞与临床病理特征和血清CEA、NSE、Cyfra21-1、pro-GRP的关系分析[J].,2022,(3):510-514 |
| 非小细胞肺癌患者外周血循环肿瘤细胞与临床病理特征和血清CEA、NSE、Cyfra21-1、pro-GRP的关系分析 |
| Analysis of the Relationship between Peripheral Blood Circulating Tumor Cells and Clinicopathologic Features and Serum CEA, NSE, Cyfra21-1 and pro-GRP in Patients with Non-Small Cell Lung Cancer |
| 投稿时间：2021-05-29 修订日期：2021-06-25 |
| DOI：10.13241/j.cnki.pmb.2022.03.023 |
| 中文关键词: 非小细胞肺癌 循环肿瘤细胞 癌胚抗原 神经元特异性烯醇化酶 细胞角蛋白21-1 |
| 英文关键词: Non-small cell lung cancer Circulating tumor cells Carcinoembryonic antigen Neuron-specifice nolase Cytokeratin 21-1 |
| 基金项目:广东省科技计划项目（20120314）；广东省江门市科技计划项目（2018A008） |
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| 摘要 目的：研究非小细胞肺癌（NSCLC）患者外周血循环肿瘤细胞（CTC）与临床病理特征及血清癌胚抗原（CEA）、神经元特异性烯醇化酶（NSE）、细胞角蛋白21-1（Cyfra21-1）、胃泌素释放肽前体（pro-GRP）的关系。方法：将中山大学附属江门医院从2018年1月～2021年1月收治的100例NSCLC患者纳入研究组，另选取同期我院收治的肺部良性病变患者50例作为对照组。检测并比较两组CTC计数及血清CEA、NSE、Cyfra21-1、pro-GRP水平，分析NSCLC患者外周血CTC与临床病理特征和血清CEA、NSE、Cyfra21-1、pro-GRP水平的关系。此外，通过受试者工作特征（ROC）曲线分析外周血CTC和血清CEA、NSE、Cyfra21-1、pro-GRP诊断NSCLC的效能。结果：研究组外周血CTC计数及血清CEA、NSE、Cyfra21-1、pro-GRP水平均高于对照组，差异有统计学意义（P＜0.05）。Pearson相关性分析结果显示：NSCLC患者外周血CTC计数和血清CEA、NSE、Cyfra21-1、pro-GRP水平均呈正相关（P＜0.05）。TNM分期为Ⅲ～Ⅳ期、有吸烟史的NSCLC患者CTC阳性比例明显高于TNM分期为Ⅰ～Ⅱ期、无吸烟史的NSCLC患者（P＜0.05）。ROC曲线分析结果显示：CTC计数及血清CEA、NSE、Cyfra21-1、pro-GRP水平联合检测诊断NSCLC的曲线下面积最大。结论：NSCLC患者外周血CTC计数升高，与血清CEA、NSE、Cyfra21-1、pro-GRP水平均存在相关性，且CTC阳性与NSCLC恶性进展和患者吸烟史有关，联合检测上述指标诊断NSCLC可获得较为理想的效能。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relationship between peripheral blood circulating tumor cells (CTC) and clinicopathologic features, serum carcinoembryonic antigen (CEA), neuron-specifice nolase (NSE), cytokeratin 21-1 (Cyfra21-1) and gastrin-releasing peptide (pro-GRP) in patients with non-small cell lung cancer (NSCLC). Methods: 100 patients with NSCLC who were admitted to Jiangmen Hospital Affiliated to Sun Yat-sen University from January 2018 to January 2021 were recorded as the study group. Another 50 patients with benign pulmonary lesions who were admitted to our hospital during the same period were selected as the control group. CTC count and serum CEA, NSE, Cyfra21-1 and pro-GRP levels of the two groups were detected and compared, the relationship between peripheral blood CTC count, clinicopathological features and serum CEA, NSE, Cyfra21-1 and pro-GRP levels in patients with NSCLC were analyzed. In addition, the efficacy of peripheral blood CTC and serum CEA, NSE, Cyfra21-1 and pro-GRP levels in the diagnosis of NSCLC was analyzed by receiver operating characteristic (ROC) curve. Results: Peripheral blood CTC count and serum CEA, NSE, Cyfra21-1 and pro-GRP levels in the study group were significantly higher than those in the control group, the differences were statistically significant (P<0.05). Pearson correlation analysis showed that peripheral blood CTC count of patients with NSCLC was positively correlated with serum CEA, NSE, Cyfra21-1 and pro-GRP (P<0.05). The positive rate of CTC in patients with NSCLC with TNM stage Ⅲ ~ Ⅳ and with smoking history were significantly higher than those in patients with NSCLC with TNM stage Ⅰ ~ Ⅱ and without smoking history (P<0.05). ROC curve analysis showed that the area under the curve of CTC count and serum CEA, NSE, Cyfra21-1 and pro-GRP was the largest in the diagnosis of NSCLC. Conclusion: The increase of peripheral blood CTC count in patients with NSCLC is correlated with the serum CEA, NSE, Cyfra21-1 and pro-GRP levels, and the CTC positive is related to the malignant progression of NSCLC and the smoking history of patients. Combined detection of the above indexes can obtain ideal efficacy in diagnosing NSCLC. |
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