| 林 博,韩 冉,张万宇,王 琦,马子坤.血清尿酸水平与老年轻度高血压患者的内皮功能相关性分析[J].,2022,(1):108-112 |
| 血清尿酸水平与老年轻度高血压患者的内皮功能相关性分析 |
| Correlation between Serum Uric Acid Level and Endothelial Function in Elderly Patients with Mild Hypertension |
| 投稿时间：2021-06-02 修订日期：2021-06-25 |
| DOI：10.13241/j.cnki.pmb.2022.01.019 |
| 中文关键词: 高血压 严重程度 血清尿酸 一氧化氮 血管舒张因子 |
| 英文关键词: Hypertension Severity Serum uric acid Nitric oxide Vasodilator factor |
| 基金项目:北京市卫计委科研基金资助项目（201606023）；北京中医药大学基本科研业务费基金资助项目（2019-JYB-JS-110） |
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| 中文摘要: |
| 摘要 目的：探讨血清尿酸水平与老年轻度高血压患者的内皮功能相关性。方法：选取我院2020年1月到2020年12月共收治的200例老年轻度高血压患者作为研究对象，所有患者均为未使用过降压药物治疗，将其分为轻度高血压组。另选取同期收治的200例高血压常规药物治疗患者作为重度高血压组与200名健康者作为对照组，对比三组患者血清尿酸水平与血管内皮功能。对观察组所有患者依照血清尿酸水平进行分组，将血清尿酸水平208-360 μmol/L的患者分为低尿酸组，共计136例，将血清尿酸水平≥360 μmol/L的患者分为高尿酸组，共计64例。对比两组患者的一般临床指标、血管内皮功能与氧化应激指标，并分析血清尿酸水平与老年轻度高血压患者的内皮功能相关性。结果：重度、轻度高血压组与对照组患者NO、ET-1、SUA水平对比差异显著，具有统计学意义（P＜0.05）；高尿酸组与低尿酸组患者TG、TC、DBP、SBP水平对比无明显差异（P＞0.05），高尿酸组患者Cr水平高于低尿酸组，组间对比，差异具有统计学意义（P＜0.05）；高尿酸组与低尿酸组患者T-AOC、GSH-Px、LHP、MDA、NO、ET-1水平对比差异显著，高尿酸组患者LHP、MDA和ET-1水平明显高于低尿酸组，高尿酸组患者T-AOC、GSH-Px、NO水平明显低于低尿酸组，组间对比，差异具有统计学意义（P＞0.05）；Spearman相关分析结果显示：TG、TC、Cr、DBP、SBP与血尿酸水平无明显相关性（P＞0.05），T-AOC、GSH-Px、NO与血清尿酸水平呈负相关（P＜0.05），LHP、MDA、ET-1与血清尿酸水平呈正相关（P＜0.05）。结论：血清尿酸水平与老年轻度高血压患者的内皮功能具有明显相关性，而且证明血尿酸水平的升高可能由患者氧化应激导致，因此氧化应激水平也是引起血管内皮功能障碍的一种潜在机制，希望本研究结果能够为高血压患者的疾病控制提供参考意见。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between serum uric acid level and endothelial function in elderly patients with mild hypertension. Methods: 200 cases of elderly patients with mild hypertension in our hospital from January 2020 to December 2020 were selected as the research object, all patients were not treated with antihypertensive drugs, and they were divided into mild hypertension group. In addition, 200 cases of patients with hypertension treated with conventional drugs in the same period were selected as the severe hypertension group and 200 healthy people as the control group. The serum uric acid level and vascular endothelial function of the three groups were compared. All patients in the observation group were grouped according to the serum uric acid level, and the serum uric acid level was < 420 μ. The patients were divided into low uric acid group (n=136) and low uric acid group (n=420) μ. The patients were divided into hyperuricemia group (n=64). The general clinical indexes, vascular endothelial function and oxidative stress indexes of the two groups were compared, and the correlation between serum uric acid level and endothelial function of elderly patients with mild hypertension was analyzed. Results: There were significant differences in the levels of no, ET-1 and SUA between the severe and mild hypertension groups and the control group (P<0.05); There was no significant difference in TG, TC, DBP and SBP levels between high uric acid group and low uric acid group (P>0.05). CR level in high uric acid group was higher than that in low uric acid group (P<0.05); The levels of T-AOC, GSH Px, LHP, MDA, no and ET-1 in high uric acid group were significantly higher than those in low uric acid group, and the levels of T-AOC, GSH PX and no in high uric acid group were significantly lower than those in low uric acid group (P>0.05); Spearman correlation analysis showed that TG, TC, Cr, DBP, SBP had no significant correlation with serum uric acid level (P>0.05), T-AOC, GSH Px, no were negatively correlated with serum uric acid level (P<0.05), LHP, MDA, ET-1 were positively correlated with serum uric acid level (P<0.05). Conclusion: Serum uric acid level is significantly correlated with endothelial function in elderly patients with mild hypertension, and it is proved that the increase of serum uric acid level may be caused by oxidative stress in patients, so oxidative stress level is also a potential mechanism of vascular endothelial dysfunction. It is hoped that the results of this study can provide reference for Disease Control of patients with hypertension. |
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