| 陶 丽,林 江,聂 萍,朱 敏,房 兵.牙周夹板联合正畸治疗对牙周炎所致前牙扇形移位患者咀嚼功能和龈沟液PGE2、sICAM-1、PAK5的影响[J].,2022,(1):83-87 |
| 牙周夹板联合正畸治疗对牙周炎所致前牙扇形移位患者咀嚼功能和龈沟液PGE2、sICAM-1、PAK5的影响 |
| Effects of Periodontal Splint Combined with Orthodontic Treatment on Masticatory Function and Gingival Crevicular Fluid PGE2, sICAM-1 and PAK5 in Patients With Fan-Shaped Displacement of Anterior Teeth Caused by Periodontitis |
| 投稿时间：2021-06-24 修订日期：2021-07-18 |
| DOI：10.13241/j.cnki.pmb.2022.01.014 |
| 中文关键词: 牙周夹板 正畸治疗 牙周炎 前牙扇形移位 咀嚼功能 PGE2 sICAM-1 PAK5 |
| 英文关键词: Periodontal splint Orthodontic treatment Periodontitis Fan shaped displacement of anterior teeth Masticatory function PGE2 sICAM-1 PAK5 |
| 基金项目:北京市医院管理局重点医学专业发展计划（ZYLX201407） |
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| 中文摘要: |
| 摘要 目的：探讨牙周夹板联合正畸治疗对牙周炎所致前牙扇形移位患者咀嚼功能和龈沟液中前列素E2（PGE2）、可溶性细胞间黏附分子-1（sICAM-1）、p2l活化激酶5（PAK5）的影响。方法：采用随机数字表法，将我院2018年2月~2020年2月间接收的93例牙周炎所致前牙扇形移位患者分为对照组（46例，牙周基础治疗、牙周夹板治疗）和研究组（47例，牙周基础治疗、牙周夹板治疗联合正畸治疗），观察两组疗效，对比两组治疗前后的牙周情况，咀嚼功能、美观度，龈沟液PGE2、sICAM-1、PAK5水平。结果：研究组的临床总有效率高于对照组（P<0.05）。研究组治疗后牙周菌斑指数（PLI）、探诊深度（PD）、牙龈指数（GI）、附着丧失（AL）、龈沟出血指数（SBI）低于对照组（P<0.05）。研究组治疗后探诊出血率、前牙咬合低于对照组，咀嚼功能评分高于对照组（P<0.05）。研究组治疗后牙周袋深度、前牙覆盖度、牙槽骨高度低于对照组（P<0.05）。研究组治疗后龈沟液PGE2、sICAM-1、PAK5水平低于对照组（P<0.05）。结论：牙周夹板联合正畸治疗可有效恢复牙周炎所致前牙扇形移位患者牙周功能和咀嚼功能，且美观效果好，还可减轻对龈沟液PGE2、sICAM-1、PAK5水平的影响。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of periodontal splint combined with orthodontic treatment on masticatory function and prostaglandin E2 (PGE2), soluble intercellular adhesion molecule-1 (sICAM-1) and p2l activated kinase (PAK5) in gingival crevicular fluid in patients with fan-shaped displacement of anterior teeth caused by periodontitis. Methods: 93 patients with fan-shaped displacement of anterior teeth caused by periodontitis who were received in our hospital from February 2018 to February 2020 were randomly divided into control group (46 cases, routine periodontal treatment and periodontal splint treatment) and study group (47 cases, routine periodontal treatment, periodontal splint treatment and orthodontic treatment) by random number table method. The curative effects of the two groups were observed, and the periodontal conditions, masticatory function, aesthetics, and the levels of PGE2, sICAM-1 and PAK5 in gingival crevicular fluid were compared before and after treatment. Results: The total clinical effective rate of the study group was higher than that of the control group (P<0.05). After treatment, the periodontal plaque index (PLI), probing depth (PD), gingival index (GI), loss of attachment (AL) and gingival sulcus bleeding index (SBI) of the study group were lower than those of the control group (P<0.05). After treatment, the probing bleeding rate and anterior teeth occlusion of the study group were lower than those of the control group, and the masticatory function score was higher than that of the control group (P<0.05). After treatment, the periodontal pocket depth, anterior teeth coverage and alveolar bone height of the study group were lower than those of the control group (P<0.05). After treatment, the levels of PGE2, sICAM-1 and PAK5 in gingival crevicular fluid of the study group were lower than those of the control group (P<0.05). Conclusion: Periodontal splint combined with orthodontic treatment can effectively restore the periodontal function and masticatory function of patients with fan-shaped displacement of anterior teeth caused by periodontitis, with good aesthetic effect, and reduce the impact on the levels of PGE2, sICAM-1 and PAK5 in gingival crevicular fluid. |
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