| 杨倩文,李天苏,王秀丽,周 婷,何楷印.反复呼吸道感染儿童血清维生素A、维生素E水平与免疫球蛋白、T淋巴细胞亚群、NK细胞及骨密度的关系分析[J].,2021,(23):4545-4548 |
| 反复呼吸道感染儿童血清维生素A、维生素E水平与免疫球蛋白、T淋巴细胞亚群、NK细胞及骨密度的关系分析 |
| Analysis of the Relationship between Serum Vitamin A, Vitamin E Levels and Immunoglobulin, T Lymphocyte Subsets, NK Cells and Bone Mineral Density in Children with Recurrent Respiratory Tract Infection |
| 投稿时间：2021-04-07 修订日期：2021-04-30 |
| DOI：10.13241/j.cnki.pmb.2021.23.031 |
| 中文关键词: 反复呼吸道感染 维生素A 维生素E 免疫球蛋白 T淋巴细胞亚群 NK细胞 骨密度 |
| 英文关键词: Recurrent respiratory tract infection Vitamin A Vitamin E Immunoglobulin T lymphocyte subsets NK cell Bone mineral density |
| 基金项目:安徽省政府妇儿工委办公室政策研究项目（2015-1201） |
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| 中文摘要: |
| 摘要 目的：探讨反复呼吸道感染（RRTI）儿童血清维生素A、维生素E水平与免疫球蛋白（Ig）、T淋巴细胞亚群、NK细胞及骨密度的关系。方法：选择2018年2月至2020年12月我院儿科收治的107例RRTI患儿（感染组）和83例同期于我院体检的健康儿童（对照组）为研究对象，检测两组血清维生素A、维生素E水平、Ig水平，外周血T淋巴细胞亚群、NK细胞占比以及骨密度。分析维生素A、维生素E与Ig、T淋巴细胞亚群、NK细胞及骨密度的相关性。结果：感染组血清维生素A、维生素E、IgG、IgA、IgM及外周血CD3+T细胞百分比、CD4+T细胞百分比、CD3-CD56+ NK细胞百分比、CD56brightNK细胞百分比、CD56dimNK细胞百分比、桡骨和胫骨骨密度均低于对照组（P＜0.05），外周血CD8+T细胞百分比高于对照组（P＜0.05）。血清维生素A及维生素E水平与外周血CD8+T细胞百分比呈负相关（P＜0.05），与IgG、IgA、IgM水平，外周血CD3+ T细胞百分比、CD4+T细胞百分比、CD3-CD56+ NK细胞百分比、CD56brightNK细胞百分比、CD56dimNK细胞百分比、桡骨和胫骨骨密度呈正相关（P＜0.05）。结论：RRTI患儿血清维生素A、维生素E水平明显降低，且与免疫功能障碍和骨密度降低有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum vitamin A and vitamin E levels and immunoglobulin (Ig), T lymphocyte subsets, NK cell subsets and bone mineral density in children with recurrent respiratory tract infection (RRTI). Methods: 107 children with RRTI (infection group) who were admitted to our hospital from February 2018 to December 2020 and 83 healthy children (control group) who underwent physical examination in our hospital during the same period were selected as the study subjects. Serum vitamin A and vitamin E levels, Ig levels, the proportion of T lymphocyte subsets, NK cell subsets in peripheral blood and bone mineral density were detected in both groups. The correlation of serum vitamin A and vitamin E and Ig, T lymphocyte subsets, NK cell subsets and bone mineral density were analyzed. Results: The serum vitamin A, vitamin E, IgG, IgA, IgM and percentage of CD3+T cells, percentage of CD4+ T cells, percentage of CD3-CD56+ NK cells, percentage of CD56brightNK cells, percentage of CD56dimNK cells, and bone mineral density of radius and tibia in the infection group were lower than those in the control group (P<0.05). The percentage of CD8+T cells was higher than that in the control group (P<0.05). The serum vitamin A and vitamin E levels were negatively correlated with the percentage of CD8+T cells (P<0.05), was positively correlated with the IgG, IgA, IgM level and the percentage of CD3+T cells, percentage of CD4+T cells, percentage of CD3-CD56+ NK cells, percentage of CD56brightNK cells, percentage of CD56dimNK cells and bone mineral density of radius and tibia (P<0.05). Conclusion: The serum vitamin A and vitamin E levels in children with RRTI are significantly decreased, which are associated with immune dysfunction and decreased bone mineral density. |
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