| 潘春燕,李凤菊,陶亚飞,王辉林,陈 静,张艳伟.磁共振扩散加权成像联合血清AFP、CA125、CEA、CA199检测在早期原发性肝癌中的诊断价值研究[J].,2021,(23):4527-4530 |
| 磁共振扩散加权成像联合血清AFP、CA125、CEA、CA199检测在早期原发性肝癌中的诊断价值研究 |
| The Diagnostic Value of Diffusion - weighted Magnetic Resonance Imaging Combined with Serum AFP, CA125, CEA and CA199 in Early Primary Liver Cancer |
| 投稿时间：2021-03-28 修订日期：2021-04-23 |
| DOI：10.13241/j.cnki.pmb.2021.23.027 |
| 中文关键词: 原发性肝癌 磁共振扩散加权成像 甲胎蛋白 癌胚抗原 糖类抗原125 糖类抗原199 转移 |
| 英文关键词: Primary liver cancer Magnetic resonance Diffusion-weighted imaging Alpha-fetoprotein Carcinoembryonic antigen 125 Carbohydrate antigen 199 Metastasis |
| 基金项目:河北省2020年度医学科学研究基金项目（20200256） |
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| 中文摘要: |
| 摘要 目的：研究磁共振扩散加权成像（DWI）联合血清甲胎蛋白（AFP）、糖类抗原125（CA125）、癌胚抗原（CEA）、糖类抗原199（CA199）检测在早期原发性肝癌（PHC）中的诊断价值。方法：选取我院自2017年9月开始至2020年5月收治的63例早期PHC患者纳入研究，记作肝癌组，再取同期我院收治的61例良性肝病患者记作对照组。对所有受试者均实施DWI扫描，比较两组DWI图像信号强度。检测并比较两组血清AFP、CA125、CEA、CA199水平，以受试者工作特征（ROC）曲线分析上述各项血清学指标水平检测和DWI诊断早期PHC的效能。另外，比较PHC淋巴结转移患者和无淋巴结转移患者血清AFP、CA125、CEA、CA199水平。结果：肝癌组DWI信号强度为高信号人数占比高于对照组（均P<0.05）。肝癌组血清AFP、CA125、CEA、CA199水平均高于对照组（均P<0.05）。血清AFP、CA125、CEA、CA199水平联合DWI诊断早期PHC的曲线下面积、灵敏度以及特异度均高于上述各检查方式单独检测。PHC淋巴结转移患者的血清AFP、CA125、CEA、CA199水平均高于无淋巴结转移患者（均P<0.05）。结论：DWI联合血清AFP、CA125、CEA、CA199检测诊断早期PHC的价值较高，且淋巴结转移患者的血清AFP、CA125、CEA、CA199水平明显升高。 |
| 英文摘要: |
| ABSTRACT Objective: To study the diagnostic value of diffused-weighted magnetic resonance imaging (DWI) combined with serum alpha-fetoprotein (AFP), carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA) and carbohydrate antigen 199 (CA199) in early primary liver cancer (PHC). Methods: 63 patients with early PHC admitted to our hospital from September 2017 to May 2020 were included in the study, which were labeled as liver cancer group. Another 61 patients with benign liver disease admitted to our hospital during the same period were taken as the control group. DWI scans were performed on all subjects, the signal intensity of DWI images between the two groups were compared. The levels of serum AFP, CA125, CEA and CA199 were detected and compared between the two groups. Receiver operating characteristic (ROC) curve was used to analyze the efficacy of the above serological indicators and DWI in the diagnosis of early PHC. In addition, the levels of serum AFP, CA125, CEA and CA199 in patients with and without PHC lymph node metastasis were compared. Results: The proportion of patients with high DWI signal intensity in liver cancer group was higher than that in control group (all P<0.05). The levels of serum AFP, CA125, CEA and CA199 in the liver cancer group were all higher than those in the control group (all P<0.05). The area under curve, sensitivity and specificity of serum AFP, CA125, CEA and CA199 combined with DWI in early PHC diagnosis were all higher than those of the above inspection methods independently detected. The levels of serum AFP, CA125, CEA and CA199 in patients with PHC lymph node metastasis were all higher than those in the non-metastasis group (all P<0.05). Conclusion: The value of DWI combined with serum AFP, CA125, CEA and CA199 in the detection and diagnosis of early PHC is relatively high, and the serum AFP, CA125, CEA and CA199 levels in patients with lymph node metastasis are significantly increased. |
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