| 潘礼刚,刘 曼,陈 烨,黄培锋,李小兵.湿润烧伤膏联合重组人碱性成纤维细胞生长因子对浅Ⅱ度烧伤患者创面肉芽组织HIF-1α、VEGF蛋白表达的影响[J].,2021,(23):4478-4482 |
| 湿润烧伤膏联合重组人碱性成纤维细胞生长因子对浅Ⅱ度烧伤患者创面肉芽组织HIF-1α、VEGF蛋白表达的影响 |
| Effect of Moisture Exposed Burn Ointment Combined with Recombinant Human Basic Fibroblast Growth Factor on HIF-1α and VEGF Protein Expression in the Wound Granulation Tissue of Patients with Superficial Second Degree Burn |
| 投稿时间：2021-04-21 修订日期：2021-05-17 |
| DOI：10.13241/j.cnki.pmb.2021.23.016 |
| 中文关键词: 湿润烧伤膏 重组人碱性成纤维细胞生长因子 浅Ⅱ度烧伤 疗效 HIF-1α VEGF |
| 英文关键词: Moisture exposed burn ointment Recombinant human basic fibroblast growth factor Superficial second degree burn Curative effect HIF-1α VEGF |
| 基金项目:天津市卫生局科技基金项目（2013K2026） |
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| 中文摘要: |
| 摘要 目的：观察湿润烧伤膏联合重组人碱性成纤维细胞生长因子（rh-bFGF）凝胶治疗浅Ⅱ度烧伤患者的疗效及对创面肉芽组织缺氧诱导因子-1α（HIF-1α）、血管内皮生长因子（VEGF）蛋白表达的影响。方法：选取天津市第一中心医院2018年12月到2020年12月之间收治的浅Ⅱ度烧伤患者70例，根据住院号单双数分为对照组和实验组两组，各35例。对照组给予rh-bFGF凝胶治疗，实验组给予湿润烧伤膏联合rh-bFGF凝胶治疗，两组均治疗2周。对比两组疗效、创面愈合率、症状消失时间、不良反应发生率、血清炎症因子水平变化和创面肉芽组织HIF-1α、VEGF蛋白表达变化。结果：实验组的临床总有效率、创面愈合率均高于对照组（P<0.05）。实验组的肿胀、疼痛、红斑、水疱、渗液症状消失时间均短于对照组（P<0.05）。治疗2周后，两组患者血清白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、超敏C反应蛋白（hs-CRP）水平较治疗前下降（P<0.05），且实验组低于对照组（P<0.05）。治疗2周后，实验组患者创面肉芽组织VEGF蛋白表达水平高于对照组，HIF-1α蛋白表达水平低于对照组（P<0.05）。对照组的不良反应发生率为11.43%，与实验组的5.71%对比差异无统计学意义（P>0.05）。结论：与单用rh-bFGF凝胶治疗相比，联合湿润烧伤膏治疗浅Ⅱ度烧伤患者可更好地促进创面愈合，改善患者症状，同时还可改善血清炎症因子水平及创面肉芽组织HIF-1α、VEGF蛋白表达，安全可靠。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the curative effect of moisture exposed burn ointment combined with recombinant human basic fibroblast growth factor (rh-bFGF) in the treatment of patients with superficial second degree burn and its effect on hypoxia inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) protein expression in the wound granulation tissue. Methods: 70 cases of patients with superficial second degree burn who were treated in Tianjin First Central Hospital from December 2018 to December 2020 were selected. According to the hospitalization number, odd or even, they were divided into two groups: control group and experimental group, 35 cases respectively. The control group was treated with rh-bFGF gel, the experimental group was treated with moisture exposed burn ointment combined with rh-bFGF gel, and both groups were treated for 2 weeks. The therapeutic effect, wound healing rate, symptom absence time, incidence rate of adverse reactions, changes in serum inflammatory factors and changes in HIF-1α and VEGF protein expression in wound granulation tissue were compared between the two groups. Results: The clinical total effective rate and wound healing rate of experimental group were higher than those of the control group (P<0.05). The time of disappearance of swelling, pain, erythema, blister and osmotic fluid of the experimental group were shorter than those of the control group (P<0.05). 2 weeks after treatment, the serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), hypersensitive C-reactive protein (hs-CRP) of the two groups were lower than those before treatment (P<0.05), and the experimental group was lower than the control group (P<0.05). 2 weeks after treatment, VEGF protein expression level in the wound granulation tissue of the experimental group was higher than that of the control group, the HIF-1α protein expression level was lower than that of the control group (P<0.05). The incidence rate of adverse reactions in the control group was 11.43%, which was not statistically significant compared with 5.71% of the experimental group (P>0.05). Conclusion: Compared with the treatment of rh-bFGF gel, combined with moisture exposed burn ointment in the treatment of patients with superficial second degree burn can better promote wound healing, improve patient symptoms, and improve the level of serum inflammatory factors and the expression of HIF-1α and VEGF protein, which is safe and reliable. |
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