| 张韫洁,李新章,索南措,马学仁,宋姿萱.康柏西普联合视网膜激光光凝对缺血型视网膜中央静脉阻塞患者球结膜微循环指标和血管内皮功能的影响[J].,2021,(22):4368-4371 |
| 康柏西普联合视网膜激光光凝对缺血型视网膜中央静脉阻塞患者球结膜微循环指标和血管内皮功能的影响 |
| Effect of Conbercept Combined with Retinal Laser Photocoagulation on Bulbar Conjunctival Microcirculation and Vascular Endothelial Function in Patients with Ischemic Central Retinal Vein Occlusion |
| 投稿时间：2021-02-23 修订日期：2021-03-18 |
| DOI：10.13241/j.cnki.pmb.2021.22.035 |
| 中文关键词: 康柏西普 视网膜激光光凝 缺血型 视网膜中央静脉阻塞 疗效 球结膜微循环 血管内皮生长因子 内皮素-1 一氧化氮 |
| 英文关键词: Conbercept Retinal laser photocoagulation Ischemic Central retinal vein occlusion Curative effect Bulbar conjunctival microcirculation Vascular endothelial growth factor Endothelin 1 Nitric oxide |
| 基金项目:青海省自然科学基金项目（2014-Z-911） |
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| 中文摘要: |
| 摘要 目的：探讨康柏西普联合视网膜激光光凝对缺血型视网膜中央静脉阻塞患者球结膜微循环指标和血管内皮功能的影响。方法：选取2016年8月到2019年9月我院收治的缺血型CRVO患者90例，按信封抽签法分为对照组（n=45，视网膜激光光凝治疗）和研究组（n=45，视网膜激光光凝联合康柏西普治疗），比较两组患者黄斑中心视网膜厚度(CMT)、球结膜微循环指标、最佳矫正视力(BCVA)、疗效、血清血管内皮生长因子（VEGF）、内皮素-1（ET-1）、一氧化氮（NO）水平以及不良反应。结果：治疗后6个月研究组临床总有效率高于对照组（P<0.05）。治疗后6个月，研究组的BCVA升高程度以及细动脉管径、细静脉管径扩大程度均大于对照组（P<0.05），CMT以及红细胞聚集积分降低程度大于对照组（P<0.05）。治疗后3 d，研究组的VEGF、ET-1降低程度大于对照组（P<0.05），NO升高程度大于对照组（P<0.05）。两组不良反应发生率对比未见差异（P>0.05）。结论：康柏西普联合视网膜激光光凝治疗缺血型CRVO疗效较好，可有效改善患者视力及球结膜微循环，同时还可改善血管内皮功能，安全可靠。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of conbercept combined with retinal laser photocoagulation on Bulbar Conjunctival Microcirculation and vascular endothelial function in patients with ischemic central retinal vein occlusion. Methods: 90 ischemic CRVO patients who were admitted to our hospital from August 2016 to September 2019 were selected, patients were divided into control group (n=45, retinal laser photocoagulation treatment) and study group (n=45, retinal laser photocoagulation combined with conbercept treatment) according to the envelope drawing method. The central retinal thickness(CMT), bulbar conjunctival microcirculation index, best corrected visual acuity(BCVA), curative effect, serum VEGF, ET-1, NO levels and adverse reactions were compared between the two groups. Results: The total clinical effective rate of the study group at 6 months after treatment was higher than that of the control group(P<0.05). 6 months after treatment, the increased degree of BCVA, the enlarged degree of arteriole diameter and arteriole diameter of the study group were higher than those of the control group(P<0.05), and the decreased degree of CMT and erythrocyte aggregation score of the study group were higher than those of the control group(P<0.05). 3 d after treatment, the decrease degree of VEGF and ET-1 of the study group were higher than that of the control group(P<0.05), and the increase degree of NO was higher than that of the control group(P<0.05). There was no difference in the incidence of ADR between the two groups(P>0.05). Conclusion: Conbercept combined with retinal laser photocoagulation is effective in the treatment of ischemic CRVO, which can effectively improve patients' visual acuity and bulbar conjunctival microcirculation, as well as improve vascular endothelial function, which is safe and reliable. |
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