| 崔 敏,彭彦平,高杰清,李 硕,杨旭升.木丹颗粒联合羟苯磺酸钙胶囊对糖尿病周围神经病变患者神经传导速度、血液流变学和氧化应激的影响[J].,2021,(22):4270-4274 |
| 木丹颗粒联合羟苯磺酸钙胶囊对糖尿病周围神经病变患者神经传导速度、血液流变学和氧化应激的影响 |
| Effects of Mudan Granule Combined with Calcium Dobesilate Capsules on Nerve Conduction Velocity, Hemorheology and Oxidative Stress in Patients with Diabetic Peripheral Neuropathy |
| 投稿时间：2021-04-21 修订日期：2021-05-16 |
| DOI：10.13241/j.cnki.pmb.2021.22.014 |
| 中文关键词: 木丹颗粒 羟苯磺酸钙胶囊 糖尿病周围神经病变 神经传导速度 血液流变学 氧化应激 |
| 英文关键词: Computed tomography Positron emission tomography Non-small cell lung cancer Dose Maximum standard uptake value |
| 基金项目:北京市科技计划项目（Z17110004017102） |
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| 中文摘要: |
| 摘要 目的：探讨木丹颗粒联合羟苯磺酸钙胶囊对糖尿病周围神经病变（DPN）患者神经传导速度、血液流变学和氧化应激的影响。方法：选取2018年9月~2020年8月期间我院收治的120例DPN患者。按照随机数字表法分为观察组（60例，木丹颗粒联合羟苯磺酸钙胶囊治疗）和对照组（60例，羟苯磺酸钙胶囊治疗），均治疗8周。对比两组疗效、神经传导速度、血液流变学和氧化应激，记录两组不良反应发生情况。结果：观察组的临床总有效率高于对照组（P<0.05）。观察组治疗后正中神经、腓总神经的运动传导速度（MNCV）和感觉传导速度（SNCV）均较治疗前升高，且高于对照组（P<0.05）。两组治疗后全血低切黏度、全血高切黏度、纤维蛋白原、血浆黏度均较治疗前降低，且观察组低于对照组（P<0.05）。两组治疗后丙二醛（MDA）较治疗前降低，超氧化物歧化酶（SOD）较治疗前升高（P<0.05），且观察组MDA较对照组低，SOD较对照组高（P<0.05）。两组不良反应发生率对比无明显差异（P>0.05）。结论：木丹颗粒联合羟苯磺酸钙胶囊治疗DPN患者疗效确切，可提高患者神经传导速度和抗氧化应激能力，改善血液流变学状态，安全可靠。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of Mudan granule combined with calcium dobesilate capsules on nerve conduction velocity, hemorheology and oxidative stress in patients with diabetic peripheral neuropathy (DPN). Methods: From September 2018 to August 2020, 120 patients with DPN were selected in our hospital. According to the random number table method, they were divided into observation group (60 cases, Mudan granules combined with calcium dobesilate capsules treatment) and control group (60 cases, calcium dobesilate capsules treatment), all of them were treated for 8 weeks. The efficacy, nerve conduction velocity, hemorheology and oxidative stress of the two groups were compared, and the adverse reactions of the two groups were recorded. Results: The clinical total effective rate of the observation group was higher than that of the control group(P<0.05). The motor conduction velocity (MNCV) and sensory conduction velocity(SNCV) of median nerve and common peroneal nerve of the observation group after treatment were higher than those before treatment, and higher than those of the control(P<0.05). The whole blood low shear viscosity, whole blood high shear viscosity, fibrinogen and plasma viscosity of the two groups were lower than those before treatment, and the observation group was lower than the control group(P<0.05). After treatment, malondialdehyde (MDA) of the two groups was lower than that before treatment, and superoxide dismutase(SOD) was higher than that before treatment(P<0.05). MDA of the observation group was lower than that of the control group, and SOD was higher than that of the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Mudan granule combined with calcium dobesilate capsules has definite efficacy in the treatment of patients with DPN, which can improve the nerve conduction velocity and antioxidant stress ability of patients, improve the state of hemorheology, and is safe and reliable. |
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