| 黄 倩,杜 蕾,昌 菁,包 蓓,刘 芳.中青年2型糖尿病患者并发轻度认知功能障碍相关影响因素研究[J].,2021,(22):4256-4261 |
| 中青年2型糖尿病患者并发轻度认知功能障碍相关影响因素研究 |
| Related Factors of Mild Cognitive Impairment in Young and Middle-aged Patients with Type 2 Diabetes Mellitus |
| 投稿时间：2021-05-10 修订日期：2021-05-30 |
| DOI：10.13241/j.cnki.pmb.2021.22.011 |
| 中文关键词: 中青年 2型糖尿病 认知功能障碍 临床特点 危险因素 |
| 英文关键词: Young and middle-aged Type 2 diabetes mellitus Cognitive impairment Clinical features Risk factors |
| 基金项目:国家自然科学基金项目（81974219） |
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| 中文摘要: |
| 摘要 目的：探究中青年2型糖尿病（T2DM）患者并发轻度认知功能障碍（MCI）的临床特点及相关影响因素。方法：选择2020年2月-2020年10月在上海交通大学医学院附属新华医院收治的中青年（18~60岁）T2DM患者，用蒙特利尔认知评估量表（MoCA）对患者进行认知功能测评，根据结果分为认知功能正常组（MoCA≥26分）和MCI组（MoCA＜26分）。收集两组患者的一般资料、生化指标以及认知功能量表得分进行两组比较，并采用Logistic回归分析中青年T2DM患者合并MCI的影响因素。结果：共收集161例中青年T2DM患者，其中认知功能正常者101例（62.73%），MCI者60例（37.27%）。MCI组在视空间与执行能力、命名、注意、语言、抽象及延迟回忆各维度的异常率均高于认知功能正常组，差异有统计学意义（P＜0.05），其中以延迟回忆受损（98.33%）最常见，其次为语言受损（90.00%）和抽象受损（81.67%）。两组年龄、受教育程度、糖尿病病程、糖化血红蛋白（HbA1c）比较，差异有统计学意义（P＜0.05）；以认知功能障碍作为因变量进行Logistic回归分析结果显示，糖尿病病程、HbA1c为中青年T2DM患者并发认知功能障碍的危险因素，受教育程度则是保护因素。结论：中青年T2DM患者认知功能障碍发生率较高，且以延迟回忆受损较为常见，糖尿病病程长、血糖控制不佳的中青年T2DM患者尤其需要注意认知功能的筛查。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical characteristics and related influencing factors of mild cognitive impairment (MCI) in young and middle-aged patients with type 2 diabetes mellitus (T2DM). Methods: Young and middle-aged T2DM patients (18-60 years old) were selected from Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine from February 2020 to October 2020. They were assessed with Montreal Cognitive Assessment Scale (MoCA). According to the results, they were divided into normal cognitive function group (MoCA≥26) and MCI group (MoCA<26). The baseline data, biochemical indexes and cognitive function scale scores of the two groups were collected and compared, and the influencing factors of young and middle-aged T2DM patients with MCI were analyzed by logistic regression. Results: A total of 161 young and middle-aged patients with T2DM were collected, including 101 patients with normal cognitive function (62.73%) and 60 patients with MCI (37.27%). The abnormal rates of visual space and executive functions, naming, attention, language, abstract thinking and delayed recall in MCI group were higher than those in normal cognitive function group(P<0.05), among which delayed recall impairment (98.33%) was the most common, followed by language impairment (90.00%) and abstract impairment (81.67%). There were significant differences in age, education level, course of diabetes and HbA1c between the two groups(P<0.05); The cognitive impairment was the dependent variable in the logistic regression analysis. The results showed that the course of diabetes and HbA1c were the risk factors, while education level was the protective factor of cognitive impairment in young and middle-aged patients with T2DM. Conclusion: The incidence of cognitive dysfunction in young and middle-aged patients with T2DM is high, and delayed memory impairment is more common. Young and middle-aged T2DM patients with long course of diabetes and poor blood glucose control need to pay more attention to the screening of cognitive function. |
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