| 彭研献,董晓斐,周娅微,邓 婷,李娇艳.茵栀黄口服液联合枯草杆菌二联活菌颗粒辅助治疗新生儿黄疸的疗效及对免疫功能和生长发育的影响[J].,2021,(19):3748-3751 |
| 茵栀黄口服液联合枯草杆菌二联活菌颗粒辅助治疗新生儿黄疸的疗效及对免疫功能和生长发育的影响 |
| Effect of Yinzhihuang Oral Liquid Combined with Live Bacillus Subtilis Particles in Adjuvant Treatment of Neonatal Jaundice and Its Influence on Immune Function and Growth and Development |
| 投稿时间：2021-04-23 修订日期：2021-05-18 |
| DOI：10.13241/j.cnki.pmb.2021.19.030 |
| 中文关键词: 茵栀黄口服液 枯草杆菌二联活菌颗粒 新生儿黄疸 疗效 免疫功能 生长发育 |
| 英文关键词: Yinzhihuang oral liquid Live bacillus subtilis particles Neonatal jaundice Curative effect Immune function Growth and development |
| 基金项目:湖南省卫生和计划生育委员会科研计划项目（C2016022）；湖南中医药大学中医学国内一流学科建设学科项目（4901-020002002） |
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| 摘要 目的：观察茵栀黄口服液联合枯草杆菌二联活菌颗粒辅助治疗新生儿黄疸的疗效及对免疫功能和生长发育的影响。方法：选取2019年12月至2020年12月我院收治的新生儿黄疸患儿121例。以随机数字表法将患儿分为两组，对照组（蓝光治疗）61例和研究组（蓝光治疗基础上采用茵栀黄口服液联合枯草杆菌二联活菌颗粒辅助治疗）60例，均治疗5 d。观察两组疗效、临床症状缓解时间、免疫功能、生长发育和不良反应情况。结果：治疗5 d后，研究组的总有效率高于对照组（P<0.05）。治疗5 d后，相比于对照组患儿，研究组患儿的胎便排空时间、退黄时间均更短（P<0.05）。治疗5 d后，相较于对照组，研究组CD8+更低，CD4+、CD3+、CD4+/CD8+更高（P<0.05）。治疗5 d后，相比于对照组患儿，研究组患儿的体质量、头围更大，身长更长（P<0.05）。研究组治疗3 d、5 d后血清总胆红素水平低于对照组（P<0.05）。对照组不良反应总发生率8.33%（5/61），与研究组的14.75%（9/60），组间比较无统计学差异（P>0.05）。结论：茵栀黄口服液联合枯草杆菌二联活菌颗粒辅助治疗新生儿黄疸可提高治疗效果，可促进血清总胆红素水平降低，缩短症状缓解时间，促进其正常生长发育，改善人体免疫力。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effect of Yinzhihuang oral liquid combined with live bacillus subtilis particles in the adjuvant treatment of neonatal jaundice and its influence on immune function and growth and development. Methods: 121 cases of neonatal jaundice who were received and cured in our hospital from December 2019 to December 2020 were selected. The children were divided into two groups by random number table method, 61 cases in the control group (blue light treatment) and 60 cases in the study group (On the basis of blue light treatment, used Yinzhihuang oral liquid combined with live bacillus subtilis particles as the adjuvant treatment), all patients were treated for 5 days. The curative effect, remission time of clinical symptoms, immune function, growth and development and adverse reactions of the two groups were observed. Results: 5d after treatment, the total effective rate of the study group was higher than that of the control group (P<0.05). 5d after treatment, compared with the children of control group, the children of study group had shorter fecal emptying time and yellowing time (P<0.05). 5d after treatment, compared with the control group, CD8+ was lower of the study group, CD3+, CD4+, CD4+ / CD8+ were higher (P<0.05). 5d after treatment, compared with the children of control group, the body weight, head circumference and body length of the children of the study group were larger (P<0.05). The level of bilirubin of the study group at 3 d and 5 d after treatment was lower than that of the control group (P<0.05). The total incidence of adverse reactions was 8.33% (5 / 61) in the control group and 14.75% (9 / 60) in the study group, and there was no significant difference between the two groups (P > 0.05). Conclusion: Yinzhihuang oral liquid combined with live bacillus subtilis particles in the adjuvant treatment of neonatal jaundice can improve the therapeutic effect, reduce the level of serum total bilirubin, shorten the remission time of symptoms, promote its normal growth and development, and improve human immunity. |
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