| 王 辉,张若青,李佳玲,王 俊,周晓娟.脑心通胶囊联合阿替普酶治疗急性脑梗死的疗效及对凝血功能、血液流变学和认知功能的影响[J].,2021,(19):3723-3727 |
| 脑心通胶囊联合阿替普酶治疗急性脑梗死的疗效及对凝血功能、血液流变学和认知功能的影响 |
| Curative Effect of Naoxintong Capsule Combined with Alteplase in the Treatment of Acute Cerebral Infarction and Its Influence on Coagulation Function, Hemorheology and Cognitive Function |
| 投稿时间：2021-04-23 修订日期：2021-05-18 |
| DOI：10.13241/j.cnki.pmb.2021.19.025 |
| 中文关键词: 脑心通胶囊 阿替普酶 急性脑梗死 疗效 凝血功能 血液流变学 认知功能 |
| 英文关键词: Naoxintong capsule Alteplase Acute cerebral infarction Curative effect Coagulation function Hemorheology Cognitive function |
| 基金项目:天津市卫生计生委科技基金项目（2016KZ0621） |
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| 中文摘要: |
| 摘要 目的：探究脑心通胶囊联合阿替普酶治疗急性脑梗死（ACI）的疗效，并观察该治疗方案对凝血功能、血液流变学和认知功能的影响。方法：选取我院于2016年6月~2020年12月期间收治的137例ACI患者。按照随机数字表法将患者分为对照组和观察组，其中对照组68例，接受阿替普酶治疗，观察组69例，接受脑心通胶囊联合阿替普酶治疗，两组均治疗10 d。比较两组治疗10 d后的临床总有效率，观察两组治疗前、治疗10d后的凝血功能、血液流变学和认知功能变化情况，记录两组肝肾功能、血常规异常情况及药物不良反应。结果：两组临床总有效率组间对比有明显差异（P＜0.05）。与治疗前比较，两组患者治疗10 d后活化部分凝血活酶时间（APTT）、凝血酶原时间（PT）、凝血酶时间（TT）均延长，D-二聚体（D-D）、全血低切黏度、全血高切黏度、血浆黏度、红细胞比容均降低（P＜0.05），且与对照组相比，观察组以上指标改善均更为显著（P＜0.05）。与治疗前比较，治疗10 d后两组患者美国国立卫生研究院卒中量表（NIHSS）评分均降低，日常生活能力量表（ADL）评分均升高（P＜0.05），且与对照组相比，观察组以上评分改善均更为显著（P＜0.05）。两组用药期间血常规、肝肾功能均无异常情况，未见严重不良反应发生。与治疗前比较，两组患者治疗10d后老年快速认知筛查量表（QCST-E）各维度评分均升高（P＜0.05），且与对照组相比，观察组改善更为显著（P＜0.05）。结论：在阿替普酶治疗基础上联合脑心通胶囊治疗ACI，可改善患者神经功能，提高患者日常生活能力，并促进凝血功能、血液流变学和认知功能改善。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the efficacy of Naoxintong capsule combined with alteplase in the treatment of acute cerebral infarction (ACI), and to observe the effects of this treatment on coagulation function, hemorheology and cognitive function. Methods: 137 patients with ACI who were admitted to our hospital from June 2016 to December 2020 were selected. According to the random number table method, the patients were divided into control group and observation group, 68 cases in the control group were treated with alteplase, 69 cases in the observation group were treated with Naoxintong capsule combined with alteplase, both groups were treated for 10 d. The clinical total effective rate of the two groups at 10 d after treatment was compared. The changes of coagulation function, hemorheology and cognitive function of the two groups before treatment and 10d after treatment were observed. The liver and kidney function, blood routine and adverse drug reactions of the two groups were recorded. Results: There was significant difference in the total effective rate between the two groups (P<0.05). Compared with before treatment, the activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) in two groups at 10 d after treatment were all prolonged, D-dimer (D-D), whole blood low shear viscosity, whole blood high shear viscosity, plasma viscosity and hematocrit all decreased(P<0.05), compared with the control group, the improvement of above indexes in the observation group was more significant(P<0.05). 10 d after treatment, the National Institutes of Health Stroke Scale (NIHSS) scores were decreased in two groups compared with those before treatment, the scores of daily living ability scale (ADL) were all increased (P<0.05), compared with the control group, the improvement of above scores in the observation group was more significant (P<0.05). There was no abnormality in blood routine, liver and kidney function in the two groups, and no serious adverse reactions occurred. Compared with before treatment, all dimensions of quick cognitive screening scale for elderly (QCST-E) scores in two groups were increased at 10 d after treatment (P<0.05), and compared with the control group, the improvement in the observation group was more significant (P<0.05). Conclusion: On the basis of alteplase treatment combined with Naoxintong capsule in the treatment of ACI, it can improve the patients' neurological function, improve the patients' activities of daily living, and promote the improvement of coagulation function, hemorheology and cognitive function. |
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