| 左 翔,卢燕勤,纪秉慧,李 勤,苏 怡.不同正畸治疗措施对正畸患者牙齿移动距离和龈沟液TNF-α、IL-2、HGF及PTX3的水平的影响[J].,2021,(18):3436-3442 |
| 不同正畸治疗措施对正畸患者牙齿移动距离和龈沟液TNF-α、IL-2、HGF及PTX3的水平的影响 |
| Effects of Different Orthodontic Treatments on Tooth Movement Distance and Levels of TNF-α, IL-2, HGF and PTX3 in Gingival Crevicular Fluid |
| 投稿时间：2021-03-08 修订日期：2021-03-31 |
| DOI：10.13241/j.cnki.pmb.2021.18.008 |
| 中文关键词: 正畸 错颌畸形 肿瘤坏死因子-α 白介素-2 肝细胞生长因子 正五聚蛋白3 |
| 英文关键词: Orthodontic Malformation Tumor necrosis factor-α Interleukin-2 Hepatocyte growth factor Pentraxins 3 |
| 基金项目:上海市自然科学基金项目（17ZR1424900） |
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| 中文摘要: |
| 摘要 目的：探讨不同正畸治疗对正畸患者牙齿移动距离以及龈沟液中肿瘤坏死因子-α（TNF-α）、白介素-2（IL-2）、肝细胞生长因子（HGF）、正五聚蛋白3（PTX3）水平的影响。方法：选择2016年7月至2019年12月我院收治的288例错颌畸形患者，按随机数字表法将患者分为四组，每组各72例。所有患者均采用方丝弓矫治器治疗，分别给予50 g（A组）、100 g （B组）、150 g（C组）、250 g（D组）的远中正畸力。观察四组正畸后1 d、3 d、1周、2周、3周、4周牙齿移动距离，以及正畸前、后1 d、3 d、1周、2周、3周、4周龈沟液中TNF-α、IL-2、HGF、PTX3水平变化和组间差异。结果：四组患者正畸后1 d、3 d、1周、2周、3周、4周牙位移距离先延长后缩短，然后再次延长后逐渐恢复基线水平（P＜0.05）。四组患者正畸后1 d、3 d、1周、2周、3周、4周TNF-α、IL-2、HGF、PTX3出现先升高后降低，再次升高后逐渐恢复基线水平趋势（P＜0.05），组间牙齿位移距离、TNF-α、IL-2、HGF、PTX3与时间存在交互效应（P＜0.05），B组正畸后1 d、3 d、1周、2周、3周、4周位移距离均大于A组（P＜0.05），C组、D组与A组比较均无统计学差异（P＞0.05）。D组正畸后1 d、3 d、1周、2周、3周、4周龈沟液TNF-α、IL-2、HGF、PTX3水平均高于A、B、C组（P＜0.05），C组高于A组和B组（P＜0.05），A组与B组比较均无统计学差异（P＞0.05）。结论：100 g正畸力可促使牙齿移动，保持正畸过程中适当的细胞因子水平，减少对牙周组织的破坏，有利于牙周组织恢复。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of different orthodontic treatments on the tooth movement distance and the levels of tumor necrosis factor-α(TNF-α), interleukin-2 (IL-2), hepatocyte growth factor (HGF) and pentraxins 3 (PTX3) in gingival crevicular fluid. Methods: 288 patients with malocclusion (malocclusion) who were admitted to our hospital from July 2016 to December 2019 were selected, and they were divided into four groups by random number table method, with 72 cases in each group. All patients were treated with square wire appliance, and were given distal orthodontic forces of 50g (group A), 100 g (group B), 150g (group C) and 250 g (group D), respectively. The tooth movement distance of the four groups was observed 1 d, 3 d, 1 week, 2 weeks, 3 weeks and 4 weeks after orthodontic treatment, as well as the changes of the levels of TNF-α, IL-2, HGF and PTX3 in gingival crevicular fluid and differences between groups at before orthodontic, 1 week, 2 weeks, 3 weeks and 4 weeks after orthodontic treatment. Results: The tooth displacement distance of the four groups was first extended and then shortened after orthodontic treatment for 1 day, 3 days, 1 week, 2 weeks, 3 weeks and 4 weeks, and then it was extended again and gradually returned to the baseline level(P<0.05). The TNF-α, IL-2, HGF and PTX3 of the four groups were increased first and then decreased after orthodontic treatment for 1 day, 3 days, 1 week, 2 weeks, 3 weeks and 4 weeks, and then gradually gone up again returned to the baseline level(P<0.05). There were interaction effects between tooth displacement distance, TNF-α, IL-2, HGF and PTX3 and time (P<0.05). The displacement distance of group B at 1 d, 3 d, 1 week, 2 weeks, 3 weeks and 4 weeks after orthodontic treatment were greater than that of group A(P<0.05). and there were no statistical differences between group C, group D and group A (P>0.05). The levels of TNF-α, IL-2, HGF and PTX3 in gingival crevicular fluid of group D at 1 d, 3 d, 1 week, 2 weeks, 3 weeks and 4 weeks after orthodontic treatment were all higher than those of group A, group B and group C(P<0.05), while those of group C were higher than those of group A and group B(P<0.05), there was no significant difference between group A and group B(P>0.05). Conclusion: 100g orthodontic force can promote the tooth movement, maintain the appropriate level of cytokines during orthodontic treatment, reduce the damage to periodontal tissue, which is conducive to the recovery of periodontal tissue. |
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