| 靳雅琼,鲁静朝,刘 凡,王梦肖,张 洁.冷冻消融术与射频消融术对心房颤动患者心理状态、血小板功能以及预后的影响[J].,2021,(17):3341-3345 |
| 冷冻消融术与射频消融术对心房颤动患者心理状态、血小板功能以及预后的影响 |
| Effects of Cryoablation and Radiofrequency Ablation on the Psychological State, Platelet Function and Prognosis of Patients with Atrial Fibrillation |
| 投稿时间：2020-12-23 修订日期：2021-01-19 |
| DOI：10.13241/j.cnki.pmb.2021.17.030 |
| 中文关键词: 冷冻消融术 射频消融术 心房颤动 心理状态 血小板功能 预后 |
| 英文关键词: Cryoablation Radiofrequency ablation Atrial fibrillation Psychological state Platelet function Prognosis |
| 基金项目:河北省2019年度医学科学研究课题（20190568） |
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| 中文摘要: |
| 摘要 目的：探讨冷冻消融术（CBA）与射频消融术（RFCA）对心房颤动患者心理状态、血小板功能以及预后的影响。方法：选择2018年1月至2019年10月在我院住院拟行消融手术的房颤患者192例，随机分为A组（n=96，RFCA治疗）和B组（n=96，CBA治疗），对比两组患者围术期指标、心理状态、血小板功能以及预后情况。结果：术后3个月，两组焦虑自评量表（SAS）、抑郁自评量表（SDS）评分均较术前降低，且B组低于A组（P<0.05）。两组PVI成功率比较无差异（P>0.05），B组冷冻最低温度低于A组，手术时间、消融时间短于A组（P<0.05）。B组术前、术后1 d血小板聚集率、血小板α颗粒膜蛋白（GMP-140）、血小板膜CD63、CD62P比较差异无统计学意义（P>0.05），术后1 d，A组血小板聚集率、GMP-140、CD63、CD62P均高于术前及B组（P<0.05）。两组并发症总发生率比较无差异（P>0.05）。B组患者疾病无进展生存率为 75.00%（72/96），高于A组的30.21%（29/96）（P<0.05）。结论：与RFCA相比，CBA治疗房颤患者，在获得相当治疗效果的同时，心理状态改善效果更佳，预后更好，同时对血小板功能影响轻微。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of cryoablation (CBA) and radiofrequency ablation (RFCA) on the psychological state, platelet function and prognosis of patients with atrial fibrillation. Methods: 192 patients with atrial fibrillation who were hospitalized in our hospital from January 2018 to October 2019 were selected. They were randomly divided into group A(n=96, RFCA treatment) and group B(n=96, CBA treatment). The perioperative indexes, psychological state, platelet function and prognosis of the two groups were compared. Results: 3 months after operation, the scores of self rating anxiety scale (SAS), self rating depression scale (SDS) of the two groups were lower than those before operation, and the scores of group B were lower than those of group A(P<0.05). There was no significant difference in the PVI success rate between the two groups(P>0.05). The lowest freezing temperature of group B was lower than that of group A, the operation time and ablation time were shorter than those of group A(P<0.05). There were no significant differences in platelet aggregation rate, platelet α granule membrane protein (GMP-140), platelet membrane CD63 and CD62P of group B before and 1d after operation(P>0.05). 1 d after operation, platelet aggregation rate, GMP-140, CD63 and CD62P of group A were higher than those before operation and group B(P<0.05). There was no significant difference in the total incidence of complications between the two groups (P>0.05). The disease progression free survival rate of group B was 75.00% (72/96), which was higher than 30.21% (29/96) of group A(P<0.05). Conclusion: Compared with RFCA, CBA in the treatment of patients with atrial fibrillation, not only achieved considerable therapeutic effect, but also had better psychological state improvement and better prognosis, and had a slight impact on platelet function. |
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