| 吕京敏,李 庆,张俊花,刘永存,白文博.超声造影对甲状腺癌包膜侵犯、淋巴结转移诊断价值及其与血清HMGB-1、sIL-2R相关性研究[J].,2021,(17):3295-3299 |
| 超声造影对甲状腺癌包膜侵犯、淋巴结转移诊断价值及其与血清HMGB-1、sIL-2R相关性研究 |
| The Value of Contrast-enhanced Ultrasound in the Diagnosis of Thyroid Cancer Capsule Invasion and Lymph Node Metastasis and its Correlation with Serum HMGB-1 and sIL-2R |
| 投稿时间：2021-02-03 修订日期：2021-02-25 |
| DOI：10.13241/j.cnki.pmb.2021.17.021 |
| 中文关键词: 超声造影 甲状腺癌 包膜侵犯 淋巴结转移 HMGB-1 sIL-2R |
| 英文关键词: Contrast-enhanced ultrasound Thyroid Cancer Capsule invasion Lymph Node Metastasis HMGB-1s IL-2R |
| 基金项目:河北省医学科学研究重点课题计划项目（20160329）；河北省石家庄市科学技术研究与发展计划项目（181460443） |
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| 中文摘要: |
| 摘要 目的：探讨超声造影对甲状腺癌包膜侵犯、淋巴结转移的诊断价值及其与血清高迁移率族蛋白1（HMGB-1）、可溶性白细胞介素-2受体（sIL-2R）相关性研究。方法：选取2019年2月至2020年8月本院收治的156例甲状腺结节患者作为研究对象。所有患者均经病理证实，根据病理结果提示包膜侵犯情况可分为侵犯组（86例，55.13%）与未侵犯组（70例，44.87%）；另外根据病理结果提示淋巴结转移情况也分为转移组（92例，58.97%）与未转移组（64例，41.03%）。术前均行常规超声、超声造影以及血清HMGB-1、sIL-2R水平检测。比较常规超声、超声造影诊断甲状腺包膜侵犯、淋巴结转移的诊断效能，并分析其与血清HMGB-1、sIL-2R水平的相关性。结果：常规超声、超声造影对甲状腺癌包膜侵犯、淋巴结转移的诊断结果差异均具有统计学意义（P<0.05）。超声造影诊断甲状腺癌包膜侵犯的准确性、敏感度显著高于常规超声（P<0.05），而两种检查方式之间特异度、阳性预测值以及阴性预测值的差异无统计学意义（P>0.05）；超声造影诊断甲状腺癌淋巴结转移的准确性、敏感度、特异度、阳性预测值以及阴性预测值均显著高于常规超声（P<0.05）。甲状腺癌包膜侵犯组、淋巴结转移组的血清HMGB-1、sIL-2R水平分别显著高于未侵犯组、未转移组（P<0.05）。结论：超声造影对甲状腺癌包膜侵犯、淋巴结转移具有一定诊断价值，而与血清HMGB1、sIL-2R水平具有相关性。因此，术前行超声造影检查以及血清HMGB1、sIL-2R水平检测对甲状腺癌患者包膜侵犯、淋巴结转移有一定提示作用，可对对临床治疗方案的选择具有重要价值。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the diagnostic value of contrast-enhanced ultrasound in thyroid cancer capsule invasion and lymph node metastasis and its correlation with serum high mobility group protein 1(HMGB-1) and soluble interleukin-2 receptor (sIL-2R). Methods: 156 patients with thyroid nodules admitted to our hospital from February 2019 to August 2020 were selected as the research objects. All patients were confirmed pathologically. According to the pathological results, the envelopment invasion can be divided into the invasion group (86 cases, 55.13%) and the non-invasive group (70 cases, 44.87%). In addition, according to the pathological results, the lymph node metastasis is also divided into The transfer group (92 cases, 58.97%) and the non-transfer group (64 cases,41.03%). Routine ultrasound, contrast-enhanced ultrasound, and serum HMGB-1 and sIL-2R levels were tested before surgery. Compare the diagnostic efficacy of conventional ultrasound and contrast-enhanced ultrasound in the diagnosis of thyroid capsule invasion and lymph node metastasis, and analyze the correlation with serum HMGB-1 and sIL-2R levels. Results: Conventional ultrasound and contrast-enhanced ultrasound had statistically significant differences in the diagnosis of thyroid cancer capsule invasion and lymph node metastasis(P<0.05). The accuracy and sensitivity of contrast-enhanced ultrasound in diagnosing thyroid cancer capsule invasion were significantly higher than that of conventional ultrasound (P<0.05), while the differences in specificity, positive predictive value and negative predictive value between the two inspection methods were not statistically significant (P>0.05). The accuracy, sensitivity, specificity, positive predictive value and negative predictive value of contrast-enhanced ultrasound in diagnosing lymph node metastasis of thyroid cancer were significantly higher than those of conventional ultrasound(P<0.05). Serum HMGB-1 and sIL-2R levels in the thyroid cancer capsule invasion group and lymph node metastasis group were significantly higher than those in the non-invasive group and non-metastasis group(P<0.05). Conclusion: Contrast-enhanced ultrasound has a certain diagnostic value for thyroid cancer capsule invasion and lymph node metastasis, and it is correlated with serum HMGB1 and sIL-2R levels. Therefore, preoperative contrast-enhanced ultrasound examination and detection of serum HMGB1 and sIL-2R levels have a certain prompting effect on capsule invasion and lymph node metastasis in patients with thyroid cancer, and can be of great value in the selection of clinical treatment options. |
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