| 袁 波,张金平,王善超,史学文,李姗姗.首荟通便胶囊联合乳果糖口服液对老年功能性便秘患者焦虑抑郁和血清胃肠激素的影响[J].,2021,(17):3281-3284 |
| 首荟通便胶囊联合乳果糖口服液对老年功能性便秘患者焦虑抑郁和血清胃肠激素的影响 |
| Effect of Shouhui Tongbian Capsule Combined with Lactulose Oral Liquid on Anxiety, Depression and Serum Gastrointestinal Hormones in Patients with Senile Functional Constipation |
| 投稿时间：2021-01-22 修订日期：2021-02-18 |
| DOI：10.13241/j.cnki.pmb.2021.17.018 |
| 中文关键词: 首荟通便胶囊 乳果糖口服液 老年 功能性便秘 疗效 焦虑 抑郁 胃肠激素 |
| 英文关键词: Shouhui Tongbian capsule Llactulose oral liquid Senile Functional constipation Curative effect Anxiety Depression Gastrointestinal hormones |
| 基金项目:山东省医药卫生科技发展计划项目（2015WS1129） |
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| 摘要 目的：探讨首荟通便胶囊联合乳果糖口服液治疗老年功能性便秘的疗效及对患者焦虑抑郁情绪和血清胃肠激素的影响。方法：选取2017年12月~2019年12月期间来我院就诊的老年功能性便秘患者150例，根据随机数字表法分为A组（n=75，乳果糖口服液治疗）和B组（n=75，首荟通便胶囊联合乳果糖口服液治疗），记录两组治疗2周后的疗效及治疗期间不良反应发生情况。比较治疗前、治疗2周后患者的血清胃动素（MTL）、P物质（SP）以及Zung焦虑自评量表（SAS）评分、Zung抑郁自评量表（SDS）评分、临床症状评分。结果：两组治疗2周后粪便性状、排便困难、排便不尽感、排便间隔等症状评分均下降，且B组低于A组（P<0.05）。B组治疗2周后的总有效率为85.33%（64/75），A组治疗2周后的总有效率为69.33%（52/75），B组总有效率高于A组（P<0.05）。两组治疗2周后SAS、SDS评分均下降，且B组低于A组（P<0.05）。两组治疗2周后血清MTL、SP升高，且B组高于A组（P<0.05）。两组不良反应发生率比较无差异（P>0.05）。结论：首荟通便胶囊联合乳果糖口服液治疗老年功能性便秘，可有效改善临床症状，调节焦虑抑郁情绪，改善患者血清胃肠激素水平，疗效较好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the Shouhui Tongbian capsule combined with lactulose oral liquid in the treatment of senile functional constipation's curative effect and its effect on anxiety, depression and serum gastrointestinal hormones in patients. Methods: 150 patients with senile functional constipation who came to our hospital from December 2017 to December 2019 were selected, and randomly divided into group A (n=75, lactulose oral liquid treatment) and group B (n=75, Shouhui Tongbian capsule combined with lactulose oral liquid) according to random number table method. The curative effect of the two groups at 2 weeks after treatment and the occurrence of adverse reactions during treatment were recorded. Serum motilin(MTL), substance P(SP), Zung self rating anxiety scale (SAS) score, Zung self rating depression scale (SDS) and clinical symptom score of patients before treatment and 2 weeks after treatment were compared. Results: 2 weeks after treatment, the scores of stool characteristics, defecation difficulty, defecation incomplete feeling and defecation interval of the two groups decreased, and the group B was lower than group A(P<0.05). The total effective rate of group B at 2 weeks after treatment was 85.33% (64/75), and the total effective rate of group A at 2 weeks after treatment was 69.33% (52/75), the total effective rate of group B was higher than that of group A(P<0.05). 2 weeks after treatment, SAS and SDS scores of two groups decreased, and group B was lower than group A(P<0.05). 2 weeks after treatment, Serum MTL and SP of two groups were increased, and group B was higher than group A(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Shouhui Tongbian capsule combined with lactulose oral liquid in the treatment of senile functional constipation, can effectively improve clinical symptoms, regulate anxiety and depression, and improve serum gastrointestinal hormones levels, with good curative effect. |
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