| 黄丽娜,舒仪琼,方朝晖,张贺美,章兴高.六味地黄丸联合小剂量雌孕激素替代疗法对围绝经期综合征患者性激素、骨密度和血脂的影响[J].,2021,(16):3120-3124 |
| 六味地黄丸联合小剂量雌孕激素替代疗法对围绝经期综合征患者性激素、骨密度和血脂的影响 |
| Effects of Liuwei Dihuang Pill Combined with Low-dose Estrogen and Progesterone Replacement Therapy on Sex Hormone, Bone Mineral Density and Blood Lipid in Patients with Perimenopausal Syndrome |
| 投稿时间：2020-11-29 修订日期：2020-12-24 |
| DOI：10.13241/j.cnki.pmb.2021.16.025 |
| 中文关键词: 六味地黄丸 小剂量 雌孕激素 围绝经期综合征 性激素 骨密度 血脂 |
| 英文关键词: Liuwei Dihuang Pill Low-dose Estrogen and progesterone Perimenopausal syndrome Sex hormone Bone mineral density Blood lipid |
| 基金项目:国家自然科学基金项目（81573944）；国家中医药管理局中医药重点学科项目（20091221）；国家中医药管理局国家中医临床研究基地业务建设第二批科研专项（JDZX201513） |
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| 中文摘要: |
| 摘要 目的：探讨六味地黄丸联合小剂量雌孕激素替代疗法对围绝经期综合征（PMS）患者性激素、骨密度和血脂的影响。方法：研究对象选取2018年12月~2020年5月期间我院接收的PMS患者93例，根据乱数表法将患者随机分为对照组（n=46）和研究组（n=47），对照组给予小剂量雌孕激素替代疗法，研究组给予六味地黄丸联合小剂量雌孕激素替代疗法，28d为一个治疗周期，对比两组患者治疗3个周期后的疗效、性激素、腰椎L2～L4骨密度、血脂、子宫内膜厚度及不良反应。结果：治疗3个周期后，研究组的总有效率为91.49%（43/47），高于对照组的76.09%（35/46）（P<0.05）。治疗3个周期后，研究组改良Kupperman评分表（KMI）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、促卵泡刺激素(FSH)、促黄体生成素(LH)低于对照组，高密度脂蛋白胆固醇（HDL-C）、子宫内膜厚度、腰椎L2～L4骨密度、雌二醇（E2）高于对照组（P<0.05）。两组不良反应总发生率对比差异无统计学意义（P>0.05）。结论：六味地黄丸联合小剂量雌孕激素替代疗法治疗PMS患者，可有效缓解临床症状，提高骨密度，改善PMS患者的性激素及血脂水平，疗效确切。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of Liuwei Dihuang Pill Combined with low-dose estrogen and progesterone replacement therapy on sex hormone, bone mineral density and blood lipid in patients with perimenopausal syndrome (PMS). Methods: 93 PMS patients who were received from December 2018 to May 2020 were selected as research objects, they were randomly divided into control group (n = 46) and study group (n = 47) according to random number table method, the control group was given low-dose estrogen and progesterone replacement therapy, the study group was given Liuwei Dihuang Pill Combined with low-dose estrogen and progesterone replacement therapy, 28d was a treatment cycle, the efficacy, sex hormone, lumbar L2-L4 bone mineral density, blood lipid, endometrial thickness and adverse reactions of patients in the two groups after 3 cycles of treatment were compared. Results: After 3 cycles of treatment, the total effective rate of the study group was 91.49% (43 / 47), which was higher than 76.09% (35 / 46) of the control group (P < 0.05). After 3 cycles of treatment, the improved kupperman scale（KMI）, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), follicle stimulating hormone (FSH), luteinizing hormone (LH) of the study group was lower than those of the control group, high density lipoprotein cholesterol (HDL-C), endometrial thickness, lumbar L2-L4 bone mineral density, estradiol (E2) were higher than those of the control group (P < 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P > 0.05). Conclusion: Liuwei Dihuang Pill Combined with low-dose estrogen and progesterone replacement therapy in the treatment of PMS patients, can effectively relieve the clinical symptoms, improve bone mineral density, improve the sex hormone and blood lipid levels of PMS patients, which with definite curative effect. |
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