| 欧英霞,杨 盼,龙 玲,何小丽,黎 丽,于秀云.多囊卵巢综合征患者血清IMA、HIF1α、Vaspin、IGF-1水平与性激素、糖脂代谢及胰岛素抵抗的关系研究[J].,2021,(14):2773-2777 |
| 多囊卵巢综合征患者血清IMA、HIF1α、Vaspin、IGF-1水平与性激素、糖脂代谢及胰岛素抵抗的关系研究 |
| Relationship between Serum IMA, HIF1α, Vaspin, IGF-1 Levels and Sex Hormone, Glucose and Lipid Metabolism, Insulin Resistance in Patients with Lycystic Ovary Syndrome |
| 投稿时间：2021-01-05 修订日期：2021-01-29 |
| DOI：10.13241/j.cnki.pmb.2021.14.037 |
| 中文关键词: 多囊卵巢综合征 IMA HIF1α Vaspin IGF-1 糖脂代谢 胰岛素抵抗 |
| 英文关键词: Polycystic ovary syndrome IMA HIF1α Vaspin IGF-1 Glucose and lipid metabolism Insulin resistance |
| 基金项目:湖南省卫健委科研计划项目（20200208） |
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| 中文摘要: |
| 摘要 目的：探讨多囊卵巢综合征（PCOS）患者血清缺血修饰白蛋白（IMA）、缺氧诱导因子1α（HIF1α）、内脏脂肪特异性丝氨酸蛋白酶抑制剂（Vaspin）、胰岛素样生长因子-1（IGF-1）水平与性激素、糖脂代谢及胰岛素抵抗的相关性。方法：选择2017年1月至2019年12月我院收治的268例PCOS患者（PCOS组），根据体质量指数（BMI）将PCOS患者分为超重/肥胖组（BMI≥24 kg/m2，161例）和正常体重组（18.5 kg/m2≤BMI＜24 kg/m2，107例），另选择135例于妇科门诊体检的健康女性志愿者为对照组。检测血清IMA、HIF1α、Vaspin、IGF-1水平以及性激素、糖脂代谢、胰岛素抵抗指标，Pearson相关性分析其相关性。结果：PCOS组血清IMA、HIF1α、Vaspin、IGF-1、睾酮（T）、促黄体生成素(LH)、促卵泡激素（FSH）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、空腹血糖（FPG）、餐后2小时血糖（2hPG）、空腹胰岛素（FINS）水平，胰岛素抵抗指数（HOMA-IR）均高于对照组（P＜0.001）。PCOS患者超重/肥胖组血清IMA、HIF1α、Vaspin、IGF-1、T、TC、LDL-C、FPG、FINS、2hPG水平，HOMA-IR均高于正常体重组（P＜0.001）。PCOS患者血清IMA、HIF1α水平与T、HOMA-IR呈正相关（P＜0.05），血清Vaspin、IGF-1水平与TC、LDL-C、FPG、FINS、2hPG 、HOMA-IR呈正相关（P＜0.05）。结论：PCOS患者血清IMA、HIF-1α、Vaspin、IGF-1水平均升高，IMA、HIF-1α、Vaspin、IGF-1均与PCOS胰岛素抵抗有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation of serum ischemia modified albumin (IMA), hypoxia inducible factor-1α(HIF1α), visceral fat specific serine protease inhibitor (Vaspin), insulin-like growth factor-1 (IGF-1) levels with sex hormones, glucose and lipid metabolism and insulin resistance in patients with polycystic ovary syndrome (PCOS). Methods: 268 PCOS patients (PCOS group) were selected from January 2017 to December 2019, and they were divided into overweight /obesity group (BMI≥24 kg / m2, 161 cases) and normal weight group (18.5 kg / m2≤BMI<24kg/m2, 107 cases) according to body mass index (BMI). Another 135 healthy female volunteers in gynecological clinic were selected as control group. The serum levels of IMA, HIF1α, Vaspin, IGF-1, sex hormone, glucose and lipid metabolism, insulin resistance and Pearson correlation analysis were performed. Results: The levels of serum IMA, HIF1α, Vaspin, IGF-1, testosterone (T), luteinizing hormone (LH), follicle stimulating hormone (FSH), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), fasting blood glucose (FPG), 2 hour postprandial blood glucose (2hPG), fasting islet insulin (FINS) and insulin resistance index (HOMA-IR) in PCOS group were higher than those in control group (P<0.001). The levels of IMA, HIF1α, Vaspin, IGF-1, T, TC, LDL-C, FPG, FINS, 2hPG and HOMA-IR in overweight / obesity group were higher than those in normal weight group (P<0.001). The levels of IMA and HIF1α were positively correlated with T and HOMA-IR (P<0.05). The levels of Vaspin and IGF-1 were positively correlated with TC, LDL-C, FPG, FINS, 2hPG and HOMA-IR (P<0.05). Conclusion: The serum levels of IMA, HIF1α, Vaspin and IGF-1 are increased in PCOS patients. IMA, HIF1α, Vaspin and IGF-1 are related to insulin resistance in PCOS. |
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