文章摘要
曹 杰,张 杰,李 民,孟发财,蔺鹏帧,黄卫东,于 娇.调强适形放疗联合替莫唑胺对脑胶质瘤患者生命质量及血清VEGF、EGF水平的影响[J].,2021,(14):2735-2738
调强适形放疗联合替莫唑胺对脑胶质瘤患者生命质量及血清VEGF、EGF水平的影响
Effects of Three Dimensional Conformal Radiotherapy Combined with Temozolomide on Quality of Life and the Levels of Serum VEGF, EGF in Patients with Glioma
投稿时间:2020-09-04  修订日期:2020-09-28
DOI:10.13241/j.cnki.pmb.2021.14.029
中文关键词: 调强适形放疗  替莫唑胺  脑胶质瘤  生命质量  血管内皮生长因子  表皮生长因子
英文关键词: Three dimensional conformal radiotherapy  Temozolomide  Glioma  Quality of life  Vascular endothelial growth factor  Epidermal growth factor
基金项目:陕西省自然科学基础研究计划项目(2016JM8073)
作者单位E-mail
曹 杰 陕西省人民医院神经外科 陕西 西安 710068 cj18092895019@163.com 
张 杰 陕西省人民医院神经外科 陕西 西安 710068  
李 民 陕西省人民医院神经外科 陕西 西安 710068  
孟发财 陕西省人民医院神经外科 陕西 西安 710068  
蔺鹏帧 陕西省人民医院神经外科 陕西 西安 710068  
黄卫东 陕西省人民医院神经外科 陕西 西安 710068  
于 娇 陕西省人民医院放疗科 陕西 西安 710068  
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中文摘要:
      摘要 目的:探讨调强适形放疗联合替莫唑胺对脑胶质瘤患者生命质量及血清表皮生长因子(EGF)、血管内皮生长因子(VEGF)水平的影响。方法:选取我院于2015年3月到2017年2月期间收治的脑胶质瘤患者86例,分为对照组(n=43,调强适形放疗治疗)和研究组(n=43,对照组的基础上联合替莫唑胺治疗),比较两组患者疗效、生命质量、生存率血清VEGF、EGF水平以及不良反应。结果:治疗6个疗程后,研究组的总有效率为69.77%(30/43),高于对照组的48.84%(21/43)(P<0.05)。治疗6个疗程后,两组血清VEGF、EGF水平均较治疗前降低,且研究组低于对照组(P<0.05)。两组不良反应发生率对比无差异(P>0.05)。治疗6个疗程后,两组生活质量量表(QOL)、卡劳夫斯基(KPS)评分升高,且研究组高于对照组(P<0.05)。研究组治疗后1年、2年、3年生存率均高于对照组(P<0.05)。结论:调强适形放疗联合替莫唑胺治疗胶质瘤患者疗效较好,可有效降低患者血清VEGF、EGF水平,且不增加不良反应发生率,同时还可有效改善患者生命质量。
英文摘要:
      ABSTRACT Objective: To investigate the effects of three dimensional conformal radiotherapy combined with temozolomide on quality of life and the levels of serum epidermal growth factor(EGF), vascular endothelial growth factor(VEGF) in patients with glioma. Methods: 86 patients with glioma who were admitted to our hospital from March 2016 to February 2017 were selected. They were divided into control group (n=43) and study group (n=43), the patients in the control group were treated with three dimensional conformal radiotherapy, the study group were treated combine with temozolomide on the basis of the control group, the curative effect, quality of life, survival rate, the levels of serum VEGF, EGF and adverse reactions in patients of the two groups were compared. Results: After 4 courses of treatment, the total efficiency rate of the study group was 69.77% (30/43), which was higher than 48.84% (21/43) of the control group (P<0.05). After 4 courses of treatment, the levels of VEGF, EGF in the two groups were lower than those of the before treatment, and the study group were lower than those of the control group (P<0.05). After 4 courses of treatment, the quality of life scale(QOL), Kalovsky (KPS) scores of the two groups were higher than those of the before treatment, and the study group were higher than those of the control group (P<0.05). The 1,2,3-year survival rate of the study group were higher than those of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Three dimensional conformal radiotherapy combined with temozolomide treat the patients with glioma has good curative effect, can effectively reduce the levels of serum VEGF, EGF of the patients, and does not increase the incidence of adverse reactions, which can effectively improve the quality of life of the patients at the same time.
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