| 段昕妤,吴 凯,朱超慧,翟俊山,张 林.还原型谷胱甘肽联合多烯磷脂酰胆碱对急性药物性肝损伤患者肝功能、肝纤维化指标及血清炎性因子的影响[J].,2021,(14):2679-2682 |
| 还原型谷胱甘肽联合多烯磷脂酰胆碱对急性药物性肝损伤患者肝功能、肝纤维化指标及血清炎性因子的影响 |
| Effects of Reduced Glutathione Combined with Polyene Phosphatidylcholine on Liver Function, Liver Fibrosis Indexes and Serum Inflammatory Factors in Patients with Acute Drug-induced Liver Injury |
| 投稿时间：2021-01-20 修订日期：2021-02-13 |
| DOI：10.13241/j.cnki.pmb.2021.14.017 |
| 中文关键词: 还原型谷胱甘肽 多烯磷脂酰胆碱 急性药物性肝损伤 肝功能 肝纤维化 炎性因子 |
| 英文关键词: Reduced glutathione Polyene phosphatidylcholine Acute drug-induced liver injury Liver function Liver fibrosis Inflammatory factors |
| 基金项目:北京市卫生科技发展专项基金项目（2017-1-033） |
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| 摘要 目的：探讨还原型谷胱甘肽联合多烯磷脂酰胆碱对急性药物性肝损伤（ADILI）患者肝功能、肝纤维化指标及血清炎性因子的影响。方法：选择2017年1月~2019年3月期间我院收治的ADILI患者100例，采用随机数字表法分为对照组和联合组，各50例。对照组给予多烯磷脂酰胆碱治疗，联合组给予还原型谷胱甘肽联合多烯磷脂酰胆碱治疗，对比两组疗效、肝功能指标[谷丙转氨酶（ALT）、谷草转氨酶（AST）、总胆红素（TBIL）和谷氨酰转肽酶（GGT）]、肝纤维化指标[层粘连蛋白（LN）、III型前胶原（PC-III）、IV型胶原（IV-C）、透明质酸酶（HA）]、血清炎性因子[白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、白介素-2（IL-2）]及不良反应。结果：对照组的总有效率为76.00%（38/50），联合组的总有效率为94.00%（47/50），联合组的总有效率高于对照组（P<0.05）。治疗4周后，两组ALT、AST、TBIL、GGT、LN、PC-III、IV-C、HA、IL-2、TNF-α、IL-6水平均较治疗前下降，且联合组低于对照组（P<0.05）。两组治疗期间不良反应发生率比较无明显差异（P>0.05）。结论：在多烯磷脂酰胆碱基础上，联合还原型谷胱甘肽治疗ADILI患者，疗效较好，可改善肝功能和肝纤维化指标，减轻机体炎症反应，且安全可靠。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of reduced glutathione combined with polyene phosphatidylcholine on liver function, liver fibrosis indexes and serum inflammatory factors in patients with acute drug-induced liver injury (ADILI). Methods: 100 patients with ADILI who were admitted in our hospital from January 2017 to March 2019 were selected, they were divided into control group and combination group by random stratified sampling method, 50 cases in each group. The control group was treated with polyene phosphatidylcholine, the combination group was treated with reduced glutathione combined with polyene phosphatidylcholine, the curative effect, liver function indexes [alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL) and glutamyltranspeptidase (GGT)], liver fibrosis indexes [laminin (LN), procollagen type III (PC-III), type IV collagen (IV-C), hyaluronidase (HA)], serum inflammatory factors [Interleukin-6 (IL-6), tumor necrosis factor -α(TNF-α), interleukin-2 (IL-2)] and adverse reactions were compared between the two groups. Results: The total effective rate of the control group was 79.00% (38 / 50), the total effective rate of the combination group was 94.00% (47/50), the total effective rate of the combination group was higher than that of control group (P<0.05). 4 weeks after treatment, the levels of ALT, AST, TBIL, GGT, LN, PC-III, IV-C, HA, IL-2, TNF-α, IL-6 in the two groups were decreased compared with those of before treatment, and the combination group was lower than the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups during treatment (P>0.05). Conclusion: On the basis of polyene phosphatidylcholine, combined with reduced glutathione treat patients with ADILI, the curative effect is good, which can improve liver function and indicators of liver fibrosis, reduce the body's inflammatory response, and it's safe and reliable. |
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