| 胡 荣,宋 婷,刘静静,郏 璠,文 雯.胃苏颗粒联合四联疗法对幽门螺杆菌相关性消化性溃疡患者血清炎性因子、胃肠激素及生活质量的影响[J].,2021,(14):2675-2678 |
| 胃苏颗粒联合四联疗法对幽门螺杆菌相关性消化性溃疡患者血清炎性因子、胃肠激素及生活质量的影响 |
| Effect of Weisu Granule Combined with Quadruple Therapy on Serum Inflammatory Factors, Gastrointestinal Hormones and Quality of Life in Patients with Helicobacter Pylori Associated Peptic Ulcer |
| 投稿时间：2020-12-21 修订日期：2021-01-15 |
| DOI：10.13241/j.cnki.pmb.2021.14.016 |
| 中文关键词: 胃苏颗粒 四联疗法 幽门螺杆菌 消化性溃疡 炎性因子 胃肠激素 生活质量 |
| 英文关键词: Weisu granule Quadruple therapy Helicobacter pylori Peptic ulcer Inflammatory factors Gastrointestinal hormone Quality of life |
| 基金项目:陕西省科技计划项目（2017K26-06-18） |
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| 中文摘要: |
| 摘要 目的：探讨胃苏颗粒联合四联疗法对幽门螺杆菌（Hp）相关性消化性溃疡患者血清炎性因子、胃肠激素及生活质量的影响。方法：选取2018年3月~2019年12月期间我院收治的Hp阳性消化性溃疡患者124例，根据奇偶数字法将患者分为对照组、联合组，各62例。对照组给予四联疗法，联合组给予胃苏颗粒联合四联疗法，疗程均为4周。对比两组疗效、Hp根除率、炎性因子水平、胃肠激素水平、生活质量及不良反应。结果：联合组Hp根除率、临床总有效率高于对照组（P<0.05）。联合组治疗4周后SF-36量表各维度评分较对照组更高（P<0.05）。联合组治疗4周后血清降钙素原（PCT）、白介素-6（IL-6）、超敏C反应蛋白（hs-CRP）水平低于对照组（P<0.05）。联合组治疗4周后胃泌素（GAS）、胃动素（MTL）低于对照组（P<0.05）。两组不良反应发生率对比差异无统计学意义（P>0.05）。结论：胃苏颗粒联合四联疗法治疗Hp相关性消化性溃疡患者，可有效改善患者体内血清炎性因子及胃肠激素水平，并提高其生活质量和Hp根除率，疗效优于单纯四联疗法。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Weisu granule combined with quadruple therapy on serum inflammatory factors, gastrointestinal hormones and quality of life in patients with helicobacter pylori（Hp）associated peptic ulcer. Methods: 124 cases of HP positive peptic ulcer patients who were admitted in our hospital from March 2018 to December 2019 were selected, they were divided into control group, combined group according to odd even number method, 62 cases per group. The control group was given quadruple therapy, and the combined group was given Weisu granule combined with quadruple therapy, the course of treatment was 4 weeks. The efficacy, HP eradication rate, levels of inflammatory factors, levels of gastrointestinal hormones, quality of life and adverse reactions were compared between the two groups. Results: HP eradication rate, clinical total effective rate of the combined group were higher than those of the control group (P<0.05). The SF-36 scale scores of each dimension in the combined group were higher than those of the control group after 4 weeks of treatment (P<0.05). The levels of serum procalcitonin (PCT), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs CRP) in the combined group were lower than those of the control group after 4 weeks of treatment (P<0.05). The gastrin (GAS), motilin (MTL) in the combined group was lower than those of the control group after 4 weeks of treatment (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Weisu granule combined with quadruple therapy in the treatment of HP related peptic ulcer, can effectively improve the levels of serum inflammatory factors and gastrin indexes of the patients, and improve their quality of life and HP eradication rate, the curative effect is better than simple quadruple therapy. |
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