文章摘要
邓 泽,冯浩绅,郑海明,杨 梅,杨加鹏.AECOPD合并PH患者血清Hcy、Cys-C水平与肺功能、动脉血气分析指标及肺动脉收缩压的关系研究[J].,2021,(14):2657-2660
AECOPD合并PH患者血清Hcy、Cys-C水平与肺功能、动脉血气分析指标及肺动脉收缩压的关系研究
Study of Relationships between Serum Hcy, Cys-C Levels and Pulmonary Function, Arterial Blood Gas Analysis Indicators and Pulmonary Arterial Systolic Pressure in AECOPD Patients with PH
投稿时间:2021-02-03  修订日期:2021-02-26
DOI:10.13241/j.cnki.pmb.2021.14.012
中文关键词: 慢性阻塞性肺疾病急性加重期  肺动脉高压  同型半胱氨酸  胱抑素C  肺功能  动脉血气分析  肺动脉收缩压
英文关键词: Acute exacerbation of chronic obstructive pulmonary disease  Pulmonary hypertension  Homocysteine  Cystatin C  Pulmonary function  Arterial blood gas analysis  Pulmonary arterial systolic blood pressure
基金项目:辽宁省自然科学基金项目(201602873)
作者单位E-mail
邓 泽 中国医科大学附属盛京医院呼吸与危重症医学科 辽宁 沈阳 110022 dengzejiayou@163.com 
冯浩绅 中国医科大学附属盛京医院呼吸与危重症医学科 辽宁 沈阳 110022  
郑海明 中国医科大学附属盛京医院呼吸与危重症医学科 辽宁 沈阳 110022  
杨 梅 中国医科大学附属盛京医院检验科 辽宁 沈阳 110022  
杨加鹏 中国医科大学附属盛京医院第十普通外科 辽宁 沈阳 110022  
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中文摘要:
      摘要 目的:探究慢性阻塞性肺疾病急性加重期(AECOPD)合并肺动脉高压(PH)患者血清同型半胱氨酸(Hcy)、胱抑素C(Cys-C)水平与肺功能、动脉血气分析指标及肺动脉收缩压的关系。方法:选择2017年12月至2019年12月我院诊治的80例AECOPD合并PH患者作为AECOPD合并PH组。同时选择80例AECOPD未合并PH患者作为单纯AECOPD组以及50名在我院进行体检的健康志愿者作为健康组。检测并比较各组受试者的血清Hcy和Cys-C水平、第一秒用力呼气容积占用力肺活量比值(FEV1/FVC)、动脉氧分压(PaO2)、第一秒用力呼气容积占预计值的百分比(FEV1%pred)、动脉二氧化碳分压(PaCO2),肺动脉收缩压(PASP),分析各指标的相关性。结果:AECOPD合并PH组血清Hcy、Cys-C水平以及PASP最高,其次为单纯AECOPD组,健康组最低(P<0.05)。健康组FEV1%pred、FEV1/FVC最高,其次为单纯AECOPD组,AECOPD合并PH组最低(P<0.05)。与单纯AECOPD组相比,AECOPD合并PH组PaO2明显下降,PaCO2明显升高(P<0.05)。经Pearson相关性分析可得,血清Hcy和Cys-C与FEV1%pred、FEV1/FVC和PaO2均呈负相关(P<0.05),而与PaCO2和PASP均呈正相关(P<0.05)。结论:血清Hcy和Cys-C水平异常升高与AECOPD患者并发PH相关,并且与AECOPD合并PH患者肺功能下降、动脉血气异常以及PASP异常升高存在相关性。
英文摘要:
      ABSTRACT Objective: To explore the relationships between serum homocysteine(Hcy), cystatin C(Cys-C)levels and pulmonary function, arterial blood gas analysis indicators and pulmonary arterial systolic pressure in acute exacerbation of chronic obstructive pulmonary disease(AECOPD)patients with pulmonary hypertension(PH). Methods: 80 patients with AECOPD combined with pH who were diagnosed and treated in our hospital from December 2017 to December 2019 were selected as the AECOPD combined with pH group. 80 patients with AECOPD without pH were selected as the simple AECOPD group and 50 volunteers who had physical examination in our hospital were selected as the healthy group at the same time. The serum Hcy and Cys-C levels, the ratio of forced expiratory volume to forced vital capacity in the first second (FEV1/FVC), arterial oxygen partial pressure (PaO2), forced expiratory volume in the first second as a percentage of predicted value (FEV1%pred), arterial partial pressure of carbon dioxide (PaCO2), pulmonary artery systolic pressure (PASP) in people who were tested of each group were measured and compared, the correlations of each indicator were analyzed. Results: Serum levels of Hcy, Cys-C and PASP were highest in the AECOPD combined with PH group, followed by the simple AECOPD group, and the lowest in the healthy group (P<0.05). The FEV1%pred, FEV1/FVC were highest in the healthy group, followed by the simple AECOPD group, and the lowest in the AECOPD combined with PH group (P<0.05). Compared with the simple AECOPD group, the PaO2 in the AECOPD combined PH group was significantly decreased, while PaCO2 was significantly increased (P<0.05). According to Pearson correlation analysis, serum Hcy and Cys-C were negatively correlated with FEV1%pred, FEV1/FVC and PaO2 (P<0.05), but positively correlated with PaCO2 and PASP (P<0.05). Conclusion: The abnormal increase of serum Hcy and Cys-C levels is related to the AECOPD patients with PH, which is also exist correlations with the decrease of pulmonary function, the abnormality of arterial blood gas and the abnormal increase of PASP in AECOPD patients with PH.
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