| 张燕北,刘晓萌,王宏力,李 鹏,井 磊.鸦胆子油乳注射液辅助化疗对大肠癌根治术后患者的临床疗效观察[J].,2021,(13):2593-2596 |
| 鸦胆子油乳注射液辅助化疗对大肠癌根治术后患者的临床疗效观察 |
| Effect Observation of Brucea Javanica Emulsion Injection Adjuvant Chemotherapy in Treatment of Patients with Colorectal Cancer after Radical Resection |
| 投稿时间：2021-01-06 修订日期：2021-01-28 |
| DOI：10.13241/j.cnki.pmb.2021.13.041 |
| 中文关键词: 鸦胆子油乳注射液 大肠癌 生活质量 肿瘤标志物 复发转移指标 |
| 英文关键词: Brucea javanica oil emulsion injection Colorectal cancer Quality of life Tumor markers Recurrence and metastasis index |
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| 中文摘要: |
| 摘要 目的：探讨鸦胆子油乳注射液辅助化疗对大肠癌根治术后患者生活质量、肿瘤标志物以及复发转移指标的影响。方法：将我院自2018年10月至2020年3月间收治的78例经病理学确诊的大肠癌并行根治术的患者作为研究对象，按照患者自愿原则及耐受情况，将患者分为对照组和观察组，每组39例。对照组患者采用常规化疗方式，观察组在常规化疗基础上辅助鸦胆子油乳注射液治疗，14 d为一个疗程，连续治疗12个疗程。分析两组患者治疗前后生活质量（KPS）评分、肿瘤标志物（血清癌胚抗原(CEA)、糖类抗原199(CA-199)、神经元特异性烯醇化酶(NSE)）和复发转移指标（转化生长因子-β1(TGF-β1)、Smad4、血管内皮细胞生长因子(VEGF)）水平的变化。结果：观察组和对照组均能提高患者的生活质量，两组治疗后的对比分析显示，观察组结果更显著提高KPS评分（P<0.05）；治疗前两组患者肿瘤标志物和复发转移指标水平差异并无统计学意义（P>0.05），治疗后两组肿瘤标志物CEA、CA-199、NSE水平均降低，观察组患者降低程度与对照组比较具有明显统计学差异性（P<0.05）；治疗后观察组患者TGF-β1和VEGF阳性率均降低，Smad4阳性率升高，观察组患者各指标降低或升高程度与对照组比较差异有统计学意义（P<0.05）。结论：鸦胆子油乳注射液辅助用于大肠癌根治术后化疗患者中，与常规的化疗方式比较，患者生活质量提高，降低复发转移的可能性，是临床值得采用的辅助化疗方式。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of brucea javanica emulsion injection on quality of life, tumor markers and recurrence and metastasis indexes in patients with colorectal cancer after radical resection. Methods: 78 cases colorectal cancer after radical resection admitted to our hospital from October 2018 to March 2020, then divided into control group and observation group according to the principle of voluntary treatment and tolerance of patients, with 39 patients in each group. Patients in the control group were treated with conventional chemotherapy, while patients in the observation group were treated with brucea javanica injection on the basis of conventional chemotherapy, with a course of 14 days as a continuous treatment for 12 courses. The clinical effects of the two groups of patients after treatment were observed, and the changes of Karnofsky scores, tumor markers (serum CEA, saccharide antigen 199(CA-199), neuron-specific enolase (NSE) and recurrence and metastasis indicators (transforming growth factor-1 (TGF-β1), Smad4, and vascular endothelial growth factor (VEGF)) levels before and after treatment were statistically analyzed. Results: Both the observation group and the control group could improve the quality of life of patients. After treatment, the comparative analysis of the two groups showed that the observation group had more significant increase in KPS score(P<0.05). Before treatment, there was no statistically significant difference in tumor markers and recurrence and metastasis indexes between the two groups(P>0.05). After treatment, tumor markers CEA,CA-199 and NSE in the two groups were all reduced, and the reduction degree of patients in the observation group was more statistically significant than that in the control group(P<0.05); The positive rates of TGF-β1 and VEGF in the observation group were reduced, while the positive rates of Smad4 were increased, there were statistically significant differences between the reduction or increase degree of each indicator in the observation group and the control group (P<0.05). Conclusion: Brucea javanica oil emulsion injection is used as adjuvant chemotherapy in colorectal cancer patients. Compared with conventional chemotherapy, the quality of life of patients is improved, the possibility of recurrence and metastasis is reduced. Therefore, it is a clinically worthy adjuvant chemotherapy method. |
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