| 张晓曼,冯 雷,童金莲,胡晓颖,寇 晨,魏彦芳.免疫增强型与普通肠内营养制剂对老年重症肺炎营养状态、肠黏膜屏障功能及T细胞亚群的影响[J].,2021,(12):2245-2248 |
| 免疫增强型与普通肠内营养制剂对老年重症肺炎营养状态、肠黏膜屏障功能及T细胞亚群的影响 |
| Effects of Immunoenhanced and Common Enteral Nutrition Preparations on Nutritional Status, Intestinal Mucosal Barrier Function and T-cell Subsets in Elderly with Severe Pneumonia |
| 投稿时间：2020-11-04 修订日期：2020-11-27 |
| DOI：10.13241/j.cnki.pmb.2021.12.010 |
| 中文关键词: 肠内营养制剂 老年 重症肺炎 营养状态 肠黏膜屏障功能 T细胞亚群 |
| 英文关键词: Enteral nutrition preparation Elderly Severe pneumonia Nutritional status Intestinal mucosal barrier function T cell subsets |
| 基金项目:北京市科技计划项目（Z181100001718160） |
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| 中文摘要: |
| 摘要 目的：观察免疫增强型与普通肠内营养制剂对老年重症肺炎营养状态、肠黏膜屏障功能及T细胞亚群的影响。方法：选择2017年7月~2020年3月期间我院收治的136例老年重症肺炎患者，根据随机数字表法分为研究组（n=68）、对照组（n=68），对照组患者给予普通肠内营养制剂进行干预，研究组给予免疫增强型肠内营养制剂进行干预，对比两组肠道菌群失调发生率、营养状态、肠黏膜屏障功能、T细胞亚群及并发症发生率。结果：研究组的肠道菌群失调发生率低于对照组（P<0.05）。并发症发生率两组对比无差异（P>0.05）。两组干预10 d后各项营养状态指标：白蛋白（ALB）、前白蛋白（PAB）、血红蛋白（HGB）均较干预前升高，且研究组高于对照组（P<0.05）。干预10 d后两组各项肠黏膜屏障功能指标：内毒素（ET）、二胺氧化酶（DAO）均较干预前降低，且研究组低于对照组（P<0.05）。干预10 d后两组CD3+、CD4+、CD4+/CD8+均较干预前升高，且研究组高于对照组（P<0.05），CD8+较干预前降低，且研究组低于对照组（P<0.05）。结论：免疫增强型肠内营养制剂与普通肠内营养制剂相比，安全性相当，但前者对老年重症肺炎患者的营养状态、肠黏膜屏障功能、免疫功能改善效果均更好，且肠道菌群失调发生率更低。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of immunoenhanced and common enteral nutrition preparations on nutritional status, intestinal mucosal barrier function and T-cell subsets in elderly with severe pneumonia. Methods: 136 elderly patients with severe pneumonia admitted to our hospital from July 2017 to March 2020 were selected, and randomly divided into study group(n=68), control group (n=68). The control group was treated with common enteral nutrition preparations for intervention, and the study group was treated with immunoenhanced enteral nutrition preparations for intervention. The incidence rarte of intestinal flora imbalance, nutritional status, intestinal mucosal barrier function, T cell subpopulation and complication rate were compared between the two groups. Results: The incidence rarte of intestinal flora imbalance in the study group was lower than that in the control group (P<0.05). No significant difference in incidence rate of complications between two groups(P>0.05). 10 d after intervention, the nutritional status indicators of the two groups: albumin (ALB), prealbumin (PAB) and hemoglobin (HGB) were higher than before intervention, and study group was higher than control group(P<0.05). 10d after intervention, functional indicators of intestinal mucosal barrier in the two groups: endotoxin(ET) and diamine oxidase (DAO) were lower than before intervention, and study group was lower than control group(P<0.05). 10 d after intervention, CD3+, CD4+, CD4+/CD8+ in two groups were higher than before intervention, and study group was higher than control group (P<0.05), and CD8+ was lower than before intervention, and study group was lower than control group(P<0.05). Conclusion: Compared with common enteral nutrition preparations, immunoenhanced enteral nutrition preparations can improve the nutritional status of elderly patients with severe pneumonia, promote recovery of intestinal mucosal barrier function, improve the body's immune function, and reduce the incidence rate of intestinal flora imbalance. |
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