| 唐平平,洪永青,高新怀,朱 蓉,王立新.稳定期慢性阻塞性肺病患者血嗜酸性粒细胞水平与炎症表型相关性研究[J].,2021,(10):1968-1971 |
| 稳定期慢性阻塞性肺病患者血嗜酸性粒细胞水平与炎症表型相关性研究 |
| Study on the Correlation between Blood Eosinophil Level and Inflammation Phenotype in Patients with Chronic Obstructive Pulmonary Disease |
| 投稿时间：2020-07-22 修订日期：2020-08-16 |
| DOI：10.13241/j.cnki.pmb.2021.10.036 |
| 中文关键词: 稳定期慢性阻塞性肺病 嗜酸性粒细胞 炎症表型 相关性 |
| 英文关键词: Stable chronic obstructive pulmonary disease Eosinophils Inflammatory phenotype Correlation |
| 基金项目:国家自然科学基金项目（81801495） |
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| 中文摘要: |
| 摘要 目的：探究稳定期慢性阻塞性肺病患者血嗜酸性粒细胞水平与炎症表型相关性研究。方法：选择淮安市第一人民医院（我院）2017年5月至2020年3月诊治的稳定期慢性阻塞性肺病患者280例，按照外周血嗜酸性粒细胞计数分为3组，嗜酸性粒细胞＜100为A组86例，嗜酸性粒细胞100~300为B组102例，嗜酸性粒细胞＞300为C组92例。同时纳入同期进行体检的健康者100例为对照组。结果：A组、B组和C组的FeNO显著高于对照组，且C组>B组>A组（P<0.05）；FEV1占预测值和FEV1/FVC 显著低于对照组（P<0.05）；A组、B组和C组的FEV1占预测值和FEV1/FVC对比无差异（P>0.05）。A组、B组和C组的CRP、IL-6、IL-8和TNF-α显著高于对照组（P<0.05），且C组>B组>A组（P>0.05）。经相关性分析发现，A组和B组患者的嗜酸性粒细胞计数与FeNO、CRP、IL-6、IL-8和TNF-α、FEV1占预测值和FEV1/FVC无明显相关性（P>0.05）。C组的嗜酸性粒细胞计数与FeNO、CRP、IL-6、IL-8和TNF-α呈正相关（P<0.05），与FEV1/FVC%呈负相关（P<0.05）；与FEV1占预测值无显著相关性（P>0.05）。结论：稳定期慢性阻塞性肺病患者外周血嗜酸性粒细胞计数与FeNO水平呈正相关，二者能够反映稳定期慢性阻塞性肺病患者气道的炎症反应，对于稳定期慢性阻塞性肺病患者炎症的评估、病情的程度及后期的治疗具有一定的临床指导意义。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between blood eosinophil level and inflammation phenotype in patients with chronic obstructive pulmonary disease. Methods: 280 patients with stable chronic obstructive pulmonary disease diagnosed and treated in Huai'an First People's Hospital (our hospital) from May 2017 to 2020 were selected and divided into 3 groups according to the level of peripheral blood eosinophils. Eosinophils <100 were 86 patients in group A. Granulocytes 100-300 were 102 patients in group B, and eosinophils> 300 were 92 patients in group C. At the same time, 100 healthy persons who were included in the physical examination during the same period were included as the control group. Results: FeNO in group A, group B and group C was significantly higher than that in control group, and group C> group B> group A (P<0.05). FEV1 accounted for the predicted value and FEV1/FVC were significantly lower than control group (P<0.05); There was no difference between the predicted value of FEV1 in Group A, Group B and Group C compared with FEV1/FVC(P>0.05). The CRP, IL-6, IL-8 and TNF-α in group A, group B and group C were significantly higher than those in control group (P<0.05), and group C> group B> group A (P>0.05). Correlation analysis found that the eosinophil counts in group A and group B were not significantly correlated with FeNO, CRP, IL-6, IL-8 and TNF-α, FEV1 accounted for the predicted value and FEV1/FVC (P>0.05). Eosinophil count in group C was positively correlated with FeNO, CRP, IL-6, IL-8 and TNF-α(P<0.05), and negatively correlated with FEV1/FVC%(P<0.05), it was predicted with FEV1 The values were not significantly correlated (P>0.05). Conclusion: Peripheral blood eosinophil count in patients with stable chronic obstructive pulmonary disease is positively correlated with FeNO levels, both of which can reflect the airway inflammation in patients with chronic obstructive pulmonary disease in stable phase. The degree and later treatment have certain clinical guidance significance. |
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