| 王佳强,李 伟,米 佳,张妮妮,王胜利,王巧云.高频超声与超声造影对甲状腺癌侵袭性的诊断价值[J].,2021,(10):1963-1967 |
| 高频超声与超声造影对甲状腺癌侵袭性的诊断价值 |
| The Diagnostic Value of High-frequency Ultrasound and Contrast-enhanced of Invasiveness of Thyroid Cancer |
| 投稿时间：2020-07-23 修订日期：2020-08-17 |
| DOI：10.13241/j.cnki.pmb.2021.10.035 |
| 中文关键词: 高频超声 超声造影 甲状腺癌 侵袭性 诊断价值 |
| 英文关键词: High-frequency ultrasound Contrast-enhanced ultrasound Thyroid cancer Invasiveness Diagnostic value |
| 基金项目:国家自然科学基金项目（81470140） |
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| 中文摘要: |
| 摘要 目的：探讨高频超声与超声造影对甲状腺癌侵袭性的诊断价值。方法：2016年2月至2019年10月选择在本院诊治的甲状腺癌患者88例作为研究对象，所有患者都给予高频超声与超声造影诊断，记录影像学特征。检测所有患者侵袭性指标表达情况并判断诊断价值。结果：在88例患者中，病理检出颈部转移性淋巴结22例(转移组)，检出率为25.0 %。转移组的病灶钙化、边界模糊、纵横比≥1、内部血流信号、低回声等比例都显著高于非转移组(P<0.05)。转移组的淋巴结长径、短径显长于非转移组(P<0.05)，两组长短径比值对比无差异(P>0.05)。转移组的峰值强度(Peak intensity，PI)、平均通过时间(Mean transit time，MTT)、达峰时间(Peak time，TIP)值显著高于非转移组(P<0.05)。转移组的ADAM9、Notch-1、CXCR4 mRNA相对表达水平都显著高于非转移组(P<0.05)。高频超声与超声造影对甲状腺癌侵袭性的诊断敏感性为95.2 %和95.5 %，特异性为100.0 %和100.0 %。结论：高频超声与超声造影对甲状腺癌侵袭性都有很好的诊断敏感性与特异性，可为甲状腺癌颈部淋巴结转移的诊断提供补充性的定性和定量分析的方法。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the diagnostic values of high-frequency ultrasound and contrast-enhanced of invasiveness of thyroid cancer. Methods: From February 2016 to October 2019, 88 cases of patients with thyroid cancer diagnosed and treated in our hospital were selected as the research subjects. All patients were given high-frequency ultrasound and ultrasound contrast diagnosis, and the imaging characteristics were recorded. Detected the expression of aggressive indexes of all patients and were to judge the diagnostic values. Results: There were 22 patients with metastatic lymph nodes in the neck were detected by pathology (metastasis group), and the detection rates were 25.0 %. The proportions of calcification, blurred border, aspect ratio≥1, internal blood flow signal, and low echo in the metastasis group were significantly higher than the non-metastatic group(P<0.05). The long and short diameters of lymph nodes in the metastatic group were significantly higher than those in the non-metastatic group(P<0.05). There were no statistically significant difference compared between the two groups in the ratio of length to diameter(P>0.05). The peak intensity (PI), mean transit time (MTT) and peak time (TIP) values of the metastasis group were significantly higher than those of the non-metastasis group(P<0.05). The relative expression levels of ADAM9, Notch-1 and CXCR4 mRNA in the metastatic group were significantly higher than those in the non-metastatic group(P<0.05). The sensitivity of high-frequency ultrasound and ultrasound contrast to the diagnosis of thyroid cancer invasion were 95.2 % and 95.5 %, and the specificity were 100.0 % and 100.0 %. Conclusion: High-frequency ultrasound and contrast-enhanced ultrasound have good diagnostic sensitivity and specificity for the invasion of thyroid cancer, and can provide complementary qualitative, quantitative analysis methods for the diagnosis of cervical lymph node metastasis of thyroid cancer. |
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