| 葛 伟,王海峰,张长江,夏明清,王皖林,戴 宏.高通量血液透析联合肾衰宁颗粒对尿毒症患者钙磷代谢、炎症反应以及营养状况的影响[J].,2021,(9):1738-1741 |
| 高通量血液透析联合肾衰宁颗粒对尿毒症患者钙磷代谢、炎症反应以及营养状况的影响 |
| Effects of High-throughput Hemodialysis Combined with Shenshuaining Granules on Calcium and Phosphorus Metabolism, Inflammatory Response, and Nutritional Status in Patients with Uremia |
| 投稿时间：2020-09-23 修订日期：2020-10-17 |
| DOI：10.13241/j.cnki.pmb.2021.09.030 |
| 中文关键词: 高通量血液透析 肾衰宁颗粒 钙磷代谢 炎症反应 营养状况 肾功能 |
| 英文关键词: High-throughput hemodialysis Shenshuaining granules Calcium and phosphorus metabolism Inflammation response Nutritional status Renal function |
| 基金项目:安徽省高校自然科学研究项目(KJ2017A1378) |
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| 中文摘要: |
| 摘要 目的：探讨高通量血液透析（HFHD）联合肾衰宁颗粒对尿毒症患者钙磷代谢、炎症反应以及营养状况的影响。方法：选取2017年1月~2019年10月在我院接受血液透析治疗的尿毒症患者114例作为研究对象，按随机数字表法分成对照组和观察组，每组各57例，对照组给予HFHD，观察组在对照组基础上口服肾衰宁颗粒。两组均治疗3个月。比较两组患者治疗前后肾功能指标，包括尿素氮（BUN）、血肌酐（Scr）、肾小球滤过率（GFR）；钙磷代谢相关指标血清钙、血清磷、甲状旁腺激素（PTH）；炎症反应指标，包括降钙素原（PCT）、C反应蛋白（CRP）、白细胞介素-6（IL-6）；营养状况指标，包括白蛋白（ALB）、血红蛋白（Hb）、血清总蛋白（TP）。结果：治疗后两组患者BUN、Scr、GFR、血清磷、PTH、PCT、CRP、IL-6较治疗前降低，血清钙、ALB、Hb、TP较治疗前升高，观察组患者BUN、Scr、GFR、血清磷、PTH、PCT、CRP、IL-6低于对照组，血清钙、ALB、Hb、TP高于对照组，差异均有统计学意义（P<0.05）。结论：HFHD联合肾衰宁颗粒治疗尿毒症，可有效改善患者的钙磷代谢和肾功能，改善机体炎症状态及营养状况。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of high-throughput hemodialysis (HFHD) combined with Shenshuaining granules on calcium and phosphorus metabolism, inflammatory response, and nutritional status in patients with uremia. Methods: The patients with uremia who underwent hemodialysis treatment in our hospital from January 2017 to October 2019 were selected as research objects, and randomly divided into control group and observation group, with 57 cases in each group. The control group was given HFHD and the observation group received Shenshuaining granules on the basis of the control group. Both groups were treated for 3 months. The renal function indexes, including urea nitrogen (BUN), blood creatinine (Scr), glomerular filtration rate (GFR). Related indexes of calcium and phosphorus metabolism including serum calcium, serum phosphorus and parathyroid hormone (PTH). Inflammatory response indicators, including procalcitonin(PCT), C-reactive protein(CRP), interleukin-6(IL-6); Nutritional status indicators include albumin (ALB), hemoglobin(Hb), and total serum protein(TP) before and after treatment were compared between the two groups. Results: After treatment, BUN, Scr, GFR, serum phosphorus, PTH, PCT, CRP and IL-6 in the two groups were lower than before treatment, serum calcium, ALB, Hb and TP were higher than before treatment. BUN, Scr, GFR, serum phosphorus, PTH, PCT, CRP and IL-6 in the observation group were lower than those in the control group, Serum calcium, ALB, Hb and TP were higher than control group, with statistical differences (P<0.05). Conclusion: HFHD combine shenshuaning granules in the treatment of uremia, which could effectively improve calcium and phosphorus metabolism and renal function of uremia patients, and improve the inflammatory state and nutritional status of the body. |
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