| 余 婷,洪 玮,王 丽,李步阳,崔 艳.清肺化痰汤灌胃治疗对急性胰腺炎大鼠相关肺损伤的作用[J].,2021,(9):1623-1626 |
| 清肺化痰汤灌胃治疗对急性胰腺炎大鼠相关肺损伤的作用 |
| Effects of Qingfei Huatan Decoction on Lung Injury in Rats with Acute Pancreatitis |
| 投稿时间：2020-10-12 修订日期：2020-10-31 |
| DOI：10.13241/j.cnki.pmb.2021.09.005 |
| 中文关键词: 清肺化痰汤 急性胰腺炎 大鼠 肺损伤 细胞凋亡 |
| 英文关键词: Qingfei Huatan Decoction Acute Pancreatitis Rats Lung Injury Apoptosis |
| 基金项目:国家自然科学基金项目（81774178；81373888） |
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| 中文摘要: |
| 摘要 目的：探讨清肺化痰汤灌胃治疗对急性胰腺炎大鼠相关肺损伤的作用。方法：45只SD大鼠随机分为3 组-正常对照组(15只)、模型组(15只)、清肺化痰组(15只)，模型组与清肺化痰组都建立了急性胰腺炎大鼠相关肺损伤模型，对照组仅开腹后轻翻胰腺组织后缝合。清肺化痰组在造模前2 h给予清肺化痰汤0.6 mL/100 g灌胃，对照组与模型组给予等量生理盐水灌胃。结果：模型组与清肺化痰组建模后24 h、36 h、48 h的血清淀粉酶、IL-6、IL-8水平都高于对照组(P<0.05)，清肺化痰组低于模型组(P<0.05)。模型组与清肺化痰组建模后24 h、36 h、48 h的肺组织病理评分、Caspase-3蛋白相对表达水平高于对照组(P<0.05)，清肺化痰组低于模型组(P<0.05)。结论：清肺化痰汤灌胃治疗急性胰腺炎大鼠相关肺损伤能调节肺脏细胞凋亡水平，抑制炎症因子的释放，从而减轻肺损伤，改善大鼠的病情。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of Qingfei Huatan Decoction on lung injury related to acute pancreatitis in rats by intragastric administration. Methods: In this study, 45 SD rats were randomly divided into 3 groups-normal control group (15 rats), model group (15 rats), Qingfei Huatan group (15 rats). The model group and the Qingfei Huatan group were established lung injury related to acute pancreatitis model; the control group was only opened the abdomen and turned the pancreatic tissue slightly and sutured it. The Qingfei Huatan group was given the Qingfei Huatan Decoction 0.6 mL/100 g by gavage 2 hours before model building, and the control group and the model group were given the same amount of normal saline by gavage. Results: The serum amylase, IL-6, and IL-8 levels of the model group and the Qingfei Huatan group 24 h, 36 h, and 48 h after modeling were higher than those of the control group (P<0.05), and the Qingfei Huatan group was lower than the model group (P<0.05). The lung tissue pathology score and the relative expression level of Caspase-3 protein 24 h, 36 h, and 48 h after modeling of the model group and the Qingfei Huatan group were higher than those of the control group (P<0.05), and the Qingfei Huatan group was lower than the model group (P<0.05). Conclusion: Qingfeihuatan Decoction can regulate lung cell apoptosis and inhibit the release of inflammatory factors in the treatment of acute pancreatitis related lung injury in rats, thereby reducing lung injury and improving the condition of rats. |
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