| 李彦荣,侯爱琴,樊阳阳,刘晓菊,惠旭东,刘 华.妊娠期糖尿病患者血清PGRN、FGF21、Vaspin水平与糖脂代谢及胰岛素抵抗的相关性分析[J].,2021,(8):1580-1583 |
| 妊娠期糖尿病患者血清PGRN、FGF21、Vaspin水平与糖脂代谢及胰岛素抵抗的相关性分析 |
| Correlation Analysis of Serum Levels of PGRN, FGF21 and Vaspin with Glycolipid Metabolism and Insulin Resistance in Patients with Gestational Diabetes Mellitus |
| 投稿时间：2020-08-24 修订日期：2020-09-18 |
| DOI：10.13241/j.cnki.pmb.2021.08.040 |
| 中文关键词: 妊娠期糖尿病 颗粒蛋白前体 成纤维细胞生长因子21 内脏脂肪组织源性丝氨酸蛋白酶抑制剂 胰岛素抵抗 糖脂代谢 |
| 英文关键词: Gestational diabetes Granuloprotein precursor Fibroblast growth factor 21 Serine protease inhibitor derived from visceral adipose tissue Insulin resistance Glucose and lipid metabolism |
| 基金项目:国家自然科学基金项目（81211418）；陕西省卫生计生委科研基金项目（2016D076） |
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| 中文摘要: |
| 摘要 目的：研究妊娠期糖尿病（GDM）患者血清颗粒蛋白前体（PGRN）、成纤维细胞生长因子21（FGF21）及内脏脂肪组织源性丝氨酸蛋白酶抑制剂（Vaspin）水平与糖脂代谢及胰岛素抵抗（IR）的相关性。方法：选取2016年1月～2020年1月我院收治的300例GDM患者纳入研究，作为观察组，另取同期于我院进行体检的健康孕妇100例作为对照组。比较两组血清PGRN、FGF21、Vaspin水平、糖脂代谢以及IR相关指标水平，并通过Pearson相关性分析血清PGRN、FGF21及Vaspin水平与糖脂代谢、IR的关系。结果：观察组血清PGRN、FGF21及Vaspin水平均高于对照组（均P＜0.05）。观察组空腹血糖（FPG）、甘油三酯（TG）、总胆固醇（TC）及低密度脂蛋白胆固醇（LDL-C）均高于对照组（均P＜0.05）。观察组胰岛素抵抗指数（HOMA-IR）高于对照组，而胰岛素β细胞功能指数（HOMA-β）低于对照组（均P＜0.05）。经Pearson相关性分析可得：GDM患者血清PGRN、FGF21及Vaspin水平与FPG、TC、TG、LDL-C、HOMA-IR均呈正相关关系，而与HOMA-β呈负相关关系（均P＜0.05）。结论：GDM患者血清PGRN、FGF21及Vaspin水平均存在异常高表达，且和糖脂代谢及IR存在密切关系，可能成为临床上GMD诊治的潜在靶点。 |
| 英文摘要: |
| ABSTRACT Objective: To study the correlation between serum granuloprotein precursor (PGRN), fibroblast growth factor 21 (FGF21) and visceral adipose tissue derived serine protease inhibitor (Vaspin) levels and glucose and lipid metabolism and insulin resistance (IR) in patients with gestational diabetes mellitus (GDM). Methods: 300 cases of patients with GDM who were admitted to our hospital from January 2016 to January 2020 were included in the study, which was recorded as the observation group. Another 100 normal pregnant women who underwent physical examination in our hospital at the same time were selected as the control group. Serum levels of PGRN, FGF21 and Vaspin, glucose and lipid metabolism and IR related indexes were compared between the two groups, and the relationship between serum levels of PGRN, FGF21 and Vaspin and glucose and lipid metabolism and IR was analyzed by Pearson correlation. Results: The serum levels of PGRN, FGF21 and Vaspin in the observation group were higher than those in the control group (all P< 0.05). Pathological fasting blood glucose (FPG), triglyceride (TG), total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) were all higher than the control group (all P<0.05). The insulin resistance index (HOMA-IR) of the observation group was higher than that of the control group, while the insulin homeostasis index (HOMA-INSULIN) was lower than that of the control group (all P<0.05). Pearson correlation analysis showed that serum levels of PGRN, FGF21 and Vaspin in GDM patients were positively correlated with FPG, TC, TG, LDL-C and HOMA-IR, while negatively correlated with HOMA-β (all P<0.05). Conclusion: Serum levels of PGRN, FGF21 and Vaspin in GDM patients are abnormal and highly expressed, and are closely related to glucose and lipid metabolism and IR, which may become a potential clinical target for GMD diagnosis and treatment. |
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