| 郝秀丽,谢 放,闫学平,王 坤,张 芳.呼吸道感染患儿EBV-DNA载量表达及其与肝肾功能损伤的关系研究[J].,2021,(7):1383-1386 |
| 呼吸道感染患儿EBV-DNA载量表达及其与肝肾功能损伤的关系研究 |
| Expression of EBV-DNA Load in Children with Respiratory Tract Infection and Its Relationship with Hepatic and Kidney Damage |
| 投稿时间：2020-09-24 修订日期：2020-10-20 |
| DOI：10.13241/j.cnki.pmb.2021.07.040 |
| 中文关键词: 呼吸道感染 爱泼斯坦-巴尔病毒 DNA载量 肝功能损伤 肾功能损伤 |
| 英文关键词: Respiratory infection Epstein-Barr Virus DNA Load Liver damage Renal damage |
| 基金项目:国家卫生计生委临床科研专项项目（W2016EWQT39） |
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| 中文摘要: |
| 摘要 目的：探讨呼吸道感染患儿爱泼斯坦-巴尔病毒（EBV）-脱氧核糖核酸（DNA）载量表达及其与肝肾功能损伤的关系研究。方法：选取2016年1月至2019年6月本院门诊及病房住院治疗经临床确诊的175例呼吸道感染儿童为研究对象，依据EBV-DNA载量水平分为阳性组（n=117）和阴性组（n=58），比较不同性别、年龄的呼吸道感染患儿EBV-DNA阳性率，根据EBV-DNA载量峰值将阳性组患儿分为EBV-DNA高载量组(n=21)、中载量组（n=35）和低载量组（n=61），比较不同EBV-DNA载量组患儿肝肾功能异常比例及血清丙氨酸转氨酶（ALT）、天冬氨酸氨基转移酶（AST）、胱抑素 C(CysC)、β2微球蛋白(β2-MG)水平，Pearson相关性分析EBV-DNA载量与ALT、AST、CysC、β2-MG的关系。结果：不同性别患儿间EBV -DNA阳性率差异无统计学意义（P>0.05），1-3、3-6岁年龄段儿童中EBV -DNA阳性率最高，不同年龄间患儿EBV -DNA阳性率差异有统计学意义（P<0.05）；EBV-DNA低载量组、中载量组、高载量组的肝异常比例为19.67%、48.57%、66.67%，肾异常比例为13.11%、42.86%、52.38%，不同EBV -DNA载量患儿肝肾功能异常比例相比，差异有统计学意义（P<0.05）；血清ALT、AST、CysC、β2-MG水平随EBV-DNA载量升高而升高（P<0.05）， EBV -DNA载量与ALT、AST、CysC、β2-MG水平呈正相关性（P＜0.05）。结论：呼吸道感染患儿EBV -DNA载量升高会增加发生肝肾功能损伤的风险，且在1-6岁儿童EBV -DNA阳性率较高，检测EBV -DNA载量有助于呼吸道感染患儿肝肾功能的损伤的评估。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression of Epstein-Barr virus (EBV)-Deoxyribonucleic acid (DNA) load in children with respiratory infection and its relationship with liver and kidney damage. Methods: A total of 175 children with respiratory tract infection who had been clinically diagnosed during outpatient and inpatient treatment in our hospital from January 2016 to June 2019 were selected as subjects. According to the EBV-DNA load level, they were divided into positive group (n=117) and negative group (n=58). The EBV-DNA positive rates in children with respiratory tract infection of different genders and ages were compared. Children in the positive group were divided into the high-load EBV-DNA group (n=21), the medium-load group (n=35) and the low-load group (n=61) according to the peak EBV-DNA load. The proportion of abnormal liver and kidney function and serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), Cystatin C(CysC) and carrier 2 microglobulin (carrier 2-MG) levels in children with different EBV-DNA load groups were compared. Pearson correlation analysis was conducted to analyze the relationship between carrier load of EBV-DNA carrier and ALT, AST, CysC and β2-MG. Results: There was no statistically significant difference in EBV-DNA positive rate among children of different genders (P>0.05), and EBV-DNA positive rate was the highest among children aged 1-3 and 3-6 years, while there was statistically significant difference in EBV-DNA positive rate among children of different ages (P<0.05). The proportion of liver abnormalities in EBV-DNA group with low load, medium load and high load were 19.67%, 48.57% and 66.67%. The proportion of renal abnormality were 13.11%, 42.86% and 52.38%, compared with the proportion of children with different EBV-DNA loads with abnormal liver and kidney function, the differences were statistically significant (P<0.05). Serum ALT, AST, CysC and β2-MG levels increased with the increase of EBV-DNA load (P<0.05), and EBV-DNA load were positively correlated with ALT, AST, CysC and β2-MG levels (P<0.05). Conclusion: Increased EBV-DNA load in children with respiratory tract infection increases the risk of liver and kidney function damage, and EBV-DNA positive rate is higher in children aged 1-6 years. Detection of EBV-DNA load can help assess liver and kidney function damage in children with respiratory tract infection. |
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