| 李爱中,安小峰,闫鹏飞,蒋 建,李华响,高 明.醒脑静联合高压氧对急性一氧化碳中毒患者脑功能、肝肾功能及血清氧自由基的影响[J].,2021,(7):1360-1364 |
| 醒脑静联合高压氧对急性一氧化碳中毒患者脑功能、肝肾功能及血清氧自由基的影响 |
| Effects of Xingnaojing Combined with Hyperbaric Oxygen on Brain Function, Liver and Kidney Function and Serum Oxygen Free Radicals in Patients with Acute Carbon Monoxide Poisoning |
| 投稿时间：2020-12-21 修订日期：2021-01-20 |
| DOI：10.13241/j.cnki.pmb.2021.07.035 |
| 中文关键词: 醒脑静 高压氧 急性一氧化碳中毒 脑功能 肝功能 肾功能 氧自由基 |
| 英文关键词: Xingnaojing Hyperbaric oxygen Acute carbon monoxide poisoning Brain function Liver function Kidney function Oxygen free radical |
| 基金项目:安徽省自然科学基金面上项目（1508085MH192） |
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| 中文摘要: |
| 摘要 目的：探讨醒脑静联合高压氧对急性一氧化碳中毒（ACOP）患者脑功能、肝肾功能及血清氧自由基的影响。方法：选取2017年1月至2020年1月期间我院收治的ACOP患者60例，按照随机数字表法将患者分为对照组（n=30）和研究组（n=30），在常规治疗的基础上，对照组给予高压氧治疗，研究组给予醒脑静联合高压氧治疗，对比两组疗效、脑功能、肝肾功能、血清氧自由基以及平均苏醒时间、平均住院时间、迟发性脑病发生率。结果：研究组的临床总有效率为93.33%（28/30），高于对照组的70.00%（21/30）（P<0.05）。两组治疗后天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、血肌酐(Scr)、血尿素氮(BUN)均较治疗前下降，且研究组低于对照组（P<0.05）。两组治疗后丙二醛 （MDA）较治疗前下降，且研究组低于对照组（P<0.05）；两组治疗后超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-PX）均较治疗前升高，且研究组高于对照组（P<0.05）。两组治疗后年龄相关性脑白质改变（ARWMC）分级量表、美国国立卫生研究院卒中量表(NIHSS)评分均较治疗前下降，且研究组低于对照组（P<0.05）；两组治疗后简易精神状态检查量表(MMSE)评分较治疗前升高，且研究组高于对照组（P<0.05）。研究组平均苏醒时间、平均住院时间均短于对照组，迟发性脑病发生率少于对照组（P<0.05）。结论：醒脑静联合高压氧治疗ACOP患者的疗效显著，有助于患者恢复，可有效清除其血清氧自由基，保护其脑功能、肝肾功能，减少迟发性脑病发生率。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Xingnaojing combined with hyperbaric oxygen on brain function, liver and kidney function and serum oxygen free radical in patients with acute carbon monoxide poisoning (ACOP). Methods: 60 patients with ACOP who were admitted to our hospital from January 2017 to January 2020 were selected, and they were divided into control group (n=30) and study group (n=30) according to random number table method. On the basis of conventional treatment, the control group was given hyperbaric oxygen treatment, and the study group was given Xingnaojing combined with hyperbaric oxygen treatment. The curative effect, brain function, liver and kidney function, serum oxygen free radical, average recovery time and average hospitalization time, incidence of delayed encephalopathy of the two groups were compared Time. Results: The clinical total effective rate of the study group was 93.33% (28/30), which was higher than 70.00% (21/30) of the control group (P<0.05). Aspartate aminotransferase (AST), alanine aminotransferase (ALT), serum creatinine (Scr) and blood urea nitrogen (BUN) of the two groups after treatment were lower than those before treatment, and the study group was lower than the control group (P<0.05). After treatment, malondialdehyde (MDA) of the two groups decreased compared with that before treatment, and the study group was lower than the control group (P<0.05), and the superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the two groups were higher than those before treatment, and the study group was higher than the control group (P<0.05). After treatment, the age-related white matter change (ARWMC) scale score and National Institutes of Health Stroke Scale (NIHSS) score in both groups were lower than those before treatment, and the study group was lower than the control group (P<0.05). The mini mental state examination (MMSE) was higher than that before treatment, and the study group was higher than the control group (P<0.05). The average recovery time and average hospitalization time in the study group were shorter than those in the control group, and the incidence of delayed encephalopathy was lower than that in the control group (P<0.05). Conclusion: Xingnaojing combined with hyperbaric oxygen in the treatment of ACOP patients has significant curative effect, which is helpful for the recovery of patients, can effectively remove the serum oxygen free radicals, protect the brain function, liver and kidney function, and reduce the incidence of delayed encephalopathy. |
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