| 王建军,朱晓燕,余云华,王小玲,李 玺.老年2型糖尿病患者血清BGP、ghrelin、YKL-40水平与胰岛素抵抗及认知功能损害的关系研究[J].,2021,(7):1324-1327 |
| 老年2型糖尿病患者血清BGP、ghrelin、YKL-40水平与胰岛素抵抗及认知功能损害的关系研究 |
| Relationship between Serum Levels of BGP, Ghrelin and YKL-40 and Insulin Resistance and Cognitive impairment in Elderly Patients with Type 2 Diabetes Mellitus |
| 投稿时间：2020-09-29 修订日期：2020-10-23 |
| DOI：10.13241/j.cnki.pmb.2021.07.027 |
| 中文关键词: 老年 2型糖尿病 骨钙素 生长激素释放多肽 人软骨糖蛋白-39 胰岛素抵抗 认知功能 |
| 英文关键词: Elderly Type 2 diabetes Osteocalcin Growth hormone releasing polypeptide Human cartilage glycoprotein-39 Insulin resistance Cognitive function |
| 基金项目:福建省自然科学基金项目（2017J01327） |
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| 中文摘要: |
| 摘要 目的：研究老年2型糖尿病（T2DM）患者血清骨钙素（BGP）、生长激素释放多肽（ghrelin）及人软骨糖蛋白-39（YKL-40）水平与胰岛素抵抗及认知功能损害的关系。方法：选择2018年1月～2019年12月我院收治的老年T2DM患者100例记作病变组，选择同期于我院进行体检的老年健康志愿者100例作为对照组。比较两组血清BGP、ghrelin及YKL-40水平，血糖、血脂、胰岛素抵抗相关指标及简易智力状态检查量表（MMSE）评分情况，并分析各指标的相关性。结果：病变组血清BGP、ghrelin水平低于对照组，而YKL-40水平高于对照组（P＜0.05）。病变组空腹血糖（FPG）、糖化血红蛋白（HbA1c）水平及胰岛素抵抗指数（HOMA-IR）均高于对照组，而空腹胰岛素（FINS）水平低于对照组（P＜0.05）。病变组除语言、延迟记忆评分与对照组对比差异无统计学意义（P＞0.05），其他各项MMSE评分均低于对照组（P＜0.05）。经Pearson相关性分析可得：老年T2DM患者血清BGP、ghrelin水平和FPG、HbA1c、HOMA-IR均呈负相关，与FINS及MMSE评分均呈正相关（P＜0.05）；而血清YKL-40水平和FPG、HbA1c、HOMA-IR均呈正相关，与FINS及MMSE评分均呈负相关（P＜0.05）。结论：老年T2DM患者的血清BGP、ghrelin存在明显低表达，而血清YKL-40水平呈明显高表达，且上述血清学指标水平均与胰岛素抵抗和认知功能损害密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relationship between serum osteocalcin (BGP), growth hormone releasing peptide (ghrelin) and human cartilage glycoprotein-39 (YKL-40) levels and insulin resistance and cognitive impairment in elderly patients with type 2 diabetes mellitus (T2DM). Methods: 100 elderly patients with T2DM who were admitted to our hospital from January 2018 to December 2019 were seelected as the lesion group. Another 100 healthy elderly volunteers who underwent physical examination in our hospital at the same time were selected as the control group. The levels of BGP, ghrelin and YKL-40, blood glucose, blood lipid and insulin resistance, cognitive impairent and simple mental state examination scale (MMSE) score were compared between the two groups, and correlation analysis was performed. Results: The serum BGP and ghrelin level of the lesion group were lower than those of the control group, while the levels of YKL-40 was higher than that of the control group (P<0.05). Fasting blood glucose (FPG), glycosylated hemoglobin (HbA1c) and insulin resistance index (HOMA-IR) levels in the lesion group were higher than those in the control group, while fasting insulin (fins) levels were lower than those in the control group (P<0.05). There was no significant difference between the pathological group and the control group except for the scores of language and delayed memory(P>0.05), Other MMSE scores were lower than those of the control group (P<0.05). According to Pearson correlation analysis, serum BGP, ghrelin, FPG, HbA1c and HOMA-IR were negatively correlated with fins and MMSE scores (P<0.05), while serum YKL-40 was positively correlated with FPG, HbA1c and HOMA-IR, and negatively correlated with fins and MMSE scores (P<0.05). Conclusion: Serum BGP and ghrelin are significantly lower in elderly T2DM patients, while serum YKL-40 is significantly higher, and the above serological indexes are closely related to insulin resistance and cognitive impairment. |
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