| 张 唯,刘 欢,郝婷婷,王 黎,赵秋芳.四妙勇安汤辅助光凝术对糖尿病视网膜病变的疗效观察及对血糖指标、尿白蛋白的影响[J].,2021,(7):1315-1319 |
| 四妙勇安汤辅助光凝术对糖尿病视网膜病变的疗效观察及对血糖指标、尿白蛋白的影响 |
| Effect of Simiao Yongan Decoction Combined with Panretinal Laser Photocoagulation on Diabetic Retinopathy |
| 投稿时间：2020-10-08 修订日期：2020-10-31 |
| DOI：10.13241/j.cnki.pmb.2021.07.025 |
| 中文关键词: 四妙勇安汤 激光光凝术 糖尿病视网膜病变 血糖 尿白蛋白 |
| 英文关键词: Simiao Yongan Decoction Panretinal laser photocoagulation Diabetic retinopathy Glucose Urinary albumin |
| 基金项目:陕西省重点研发计划项目(2017SF-227) |
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| 中文摘要: |
| 摘要 目的：研究四妙勇安汤辅助全视网膜激光光凝术（Panretinal laser photocoagulation, PRP）对糖尿病视网膜病变（diabetic retinopathy, DR）患者的疗效及对血糖指标和尿白蛋白排泄率（urinary albumin excretion rate, UAER）的影响。方法：选取2018年6月至2020年2月期间陕西中医药大学附属医院（我院）收治DR患者50例85眼，采用随机数字表法分为对照组和观察组，其中对照组25例43眼，观察组25例42眼。对照组给予PRP治疗，观察组在对照组的基础上给予四妙勇安汤，连续服用28 d后评价两组患者的疗效及安全性，并检测两组患者治疗前后的最佳矫正视力（best corrected visual acuity, BVCA）、平均视野缺损（mean visual field defect, MD）、黄斑中心厚度（central macular thickness, CMT）、血糖相关指标及UAER。结果：治疗后，观察组总有效率（95.24 %）高于对照组（81.39 %，P＜0.05）。治疗后1个月和3个月时两组的BVCA显著升高，CMT均显著降低（P＜0.05），且观察组均优于对照组（P＜0.05）；治疗后1个月和3个月时两组的BVCA和CMT对比也存在差异（P<0.05）。与治疗前对比，两组治疗1个月MD值均降低，治疗3个月升高（P<0.05），且观察组治疗后1个月和3个月时的MD均高于对照组（P＜0.05）。治疗后观察组患者的空腹血糖（fasting blood glucose, FBG）、空腹胰岛素（fasting insulin,FINS）、糖化血红蛋白（HbA1c）和UAER与治疗前相比显著降低（P＜0.05）。两组患者研究期间的未见明显的不良反应。结论：四妙勇安汤联合PRP治疗DR疗效显著，患者BVCA、MD和CMT均得以改善，FBG、HbA1c、FINS水平和UAER均显著降低，且联合应用未见明显不良反应发生，值得临床推广。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the efficacy of Simiao Yongan Decoction combined with panretinal laser photocoagulation(PRP) in the treatment of diabetic retinopathy(DR) and the effect on glucose indexes and urinary albumin excretion rate(UAER). Methods: A total of 50 (85 eyes) patients with DR, who were admitted to Affiliated Hospital of Shaanxi University of Chinese Medicine from June 2018 to Februay 2020, were selected and randomly divived into control group(25 cases, 43eyes) and observation group(25 cases, 42eyes). The control group was treated with PRP, the observation group was treated with Simiao Yongan Decoction combined with PRP. After 28 days of treatment, the efficacy and safety were evaluated; the best corrected visual acuity(BVCA), mean visual field defect(MD), central macular thickness(CMT), glucose indexes and UAER of the two groups were detected before and after treatment. Results: After treatment, the total effective rate (95.24 %) of the observation group was higher than that (81.39 %) of the control group (P＜0.05). 1 month and 3 months after treatment, the BVCA and CMT of the two groups were significantly increased (P＜0.05); the observation group was better than the control group (P＜0.05); there was also difference in the comparison of BVCA and CMT between the two groups (P<0.05). Compared with before treatment, the MD values of the two groups were reduced for 1 month after treatment, and increased for 3 months after treatment (P<0.05), and the MD values of the observation group at 1 and 3 months after treatment were higher than those of the control group (P＜0.05). After treatment, the fasting blood glucose(FBG), fasting insulin(FINS), HbA1c and UAER of the observation group were decreased compared with before treatment (P＜0.05). There were no obvious adverse reactions during the study period of the two groups of patients. Conclusion: Simiao Yongan Decoction combined with PRP has significant efficacy in the treatment of patients with DR. The BVCA. MD and CMT were improved; the levels of FBG, FINS, HbA1c and UAER were decrease, without obvious adverse reactions, which deserves clinical promotion. |
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