| 王 冰,晏纪军,段 争,马建刚,王惠琴,李天浩.哮喘大鼠血清IL-8、IFN-γ水平与疾病分期的相关性[J].,2021,(7):1239-1243 |
| 哮喘大鼠血清IL-8、IFN-γ水平与疾病分期的相关性 |
| Correlation between Serum IL-8, IFN-γ Levels and Disease Stages in Asthmatic Rats |
| 投稿时间：2020-08-22 修订日期：2020-09-17 |
| DOI：10.13241/j.cnki.pmb.2021.07.008 |
| 中文关键词: 哮喘 大鼠 白介素-8 干扰素-γ 疾病分期 相关性 |
| 英文关键词: Asthma Rats Interleukin-8 Interferon-γ Disease stage Correlation |
| 基金项目:陕西省科技厅基金项目（一般项目-面上项目）（2020JM596） |
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| 中文摘要: |
| 摘要 目的：探讨哮喘大鼠血清白介素(Interleukin，IL)-8、干扰素(Interferon，IFN)-γ水平与疾病分期的相关性。方法：健康级56只SD雄性大鼠随机平分为急性哮喘组(n=14)、慢性哮喘组(n=14)、哮喘缓解组(n=14)和正常对照组(n=14)，建立相应模型后，检测血清IL-8、IFN-γ水平并进行相关性分析。结果：急性哮喘组、慢性哮喘组、哮喘缓解组的哮喘症状评分、IL-8含量、细胞计数与嗜酸性粒细胞计数高于正常对照组(P<0.05)，慢性哮喘组高于急性哮喘组、哮喘缓解组(P<0.05)。急性哮喘组、慢性哮喘组、哮喘缓解组的血清IFN-γ含量低于正常对照组(P<0.05)，慢性哮喘组低于急性哮喘组、哮喘缓解组(P<0.05)。在哮喘大鼠中，Pearson相关分析显示血清IL-8、IFN-γ含量与疾病分期存在相关性(P<0.05)。结论：哮喘大鼠多伴随有IL-8的高表达与IFN-γ的低表达，两者的表达水平与疾病分期存在相关性，可用于临床病情判断与治疗指导。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between serum levels of Interleukin (IL)-8, Interferon (IFN)-γ and disease stages in asthmatic rats. Methods: A total of 56 healthy SD male rats were randomly divided into acute asthma group (n=14), chronic asthma group (n=14), asthma relief group (n=14) and normal control group (n=14). After establishing the corresponding model, the serum IL-8 and IFN-γ levels of all the rats were detected and given correlation analysis. Results: The asthma symptom scores, IL-8 content, cell count and eosinophil count of the acute asthma group, chronic asthma group, and asthma relief group were higher than those of the normal control group (P<0.05), and the chronic asthma group was higher than the acute asthma group and asthma relief group (P<0.05). The serum IFN-γ levels in the acute asthma group, chronic asthma group, and asthma relief group were lower than those in the normal control group (P<0.05), and the chronic asthma group was lower than the acute asthma group and asthma relief group (P<0.05). In asthmatic rats, Pearson correlation analysis showed that serum IL-8 and IFN-γ levels were correlated with disease stages (P<0.05). Conclusion: Asthma rats are mostly accompanied by high expression of IL-8 and low expression of IFN-γ. The expression levels of the IL-8 and IFN-γ are correlated with disease stages, which can be used for clinical disease judgment and treatment guidance. |
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