| 金 玮,陈 红,王 琴,丁绍慧,刘龙生,周 涛,万玉峰.通窍鼻炎片联合克拉霉素对慢性鼻窦炎患者嗅觉功能、鼻黏液纤毛传输速度及血清炎性因子的影响[J].,2021,(6):1143-1146 |
| 通窍鼻炎片联合克拉霉素对慢性鼻窦炎患者嗅觉功能、鼻黏液纤毛传输速度及血清炎性因子的影响 |
| Effect of Tongqiao Biyan Tablet Combined with Clarithromycin on Olfactory Function, Nasal Mucociliary Transport Velocity and Serum Inflammatory Factors in Patients with Chronic Sinusitis |
| 投稿时间：2020-08-26 修订日期：2020-09-22 |
| DOI：10.13241/j.cnki.pmb.2021.06.032 |
| 中文关键词: 通窍鼻炎片 克拉霉素 慢性鼻窦炎 嗅觉功能 鼻黏液纤毛传输速度 炎性因子 |
| 英文关键词: Tongqiao Biyan tablet Clarithromycin Chronic sinusitis Olfactory function Nasal mucociliary transport velocity Inflammatory factors |
| 基金项目:国家自然科学基金项目（81700898） |
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| 中文摘要: |
| 摘要 目的：探讨通窍鼻炎片联合克拉霉素对慢性鼻窦炎患者嗅觉功能、鼻黏液纤毛传输速度及血清炎性因子的影响。方法：于2017年11月~2020年6月期间，选取我院门诊收治的慢性鼻窦炎患者86例。根据入院序号奇偶性将患者分为对照组和观察组，各43例。对照组采用克拉霉素治疗，观察组采用通窍鼻炎片联合克拉霉素治疗，均治疗4周。对比两组疗效、临床症状评分、嗅觉功能、鼻黏液纤毛传输速度及血清炎性因子，记录两组不良反应发生情况。结果：观察组的临床总有效率高于对照组（P<0.05）。两组治疗4周后T＆T主观嗅觉测试法分级均较治疗前改善，且观察组的改善效果优于对照组（P<0.05）。两组不良反应发生率对比无明显差异（P>0.05）。治疗4周后，两组鼻黏膜纤毛输送率（MTR）和鼻黏膜纤毛清除率（MCC）均较治疗前升高，且观察组高于对照组（P<0.05）。治疗4周后，两组血清白介素-5（IL-5）、白介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平均较治疗前降低，且观察组低于对照组（P<0.05）。治疗4周后，观察组鼻塞、头晕头痛、鼻漏、嗅觉下降、流涕、喷嚏症状评分低于对照组（P<0.05）。结论：通窍鼻炎片联合克拉霉素治疗慢性鼻窦炎患者疗效显著，可有效改善患者嗅觉功能及鼻黏液纤毛传输速度，缓解临床症状并降低机体炎性因子水平，且安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Tongqiao Biyan tablet combined with clarithromycin on olfactory function, nasal mucociliary transport velocity and serum inflammatory factors in patients with chronic sinusitis. Methods: 86 patients with chronic sinusitis in our outpatient department from November 2017 to June 2020 were selected. The patients were divided into the control group and the observation group according to the parity of admission serial number, 43 cases in each group. The control group was treated with clarithromycin, and the observation group was treated with Tongqiao Biyan tablets combined with clarithromycin, all patients were treated for 4 weeks. The curative effect, clinical symptom score, olfactory function, nasal mucociliary transport velocity and serum inflammatory factors were compared between the two groups, and the incidence of adverse reactions between the two groups was recorded. Results: The total effective rate of the observation group was higher than that of the control group (P<0.05). 4 weeks after treatment, T & T subjective olfactory test scores of the two groups were improved compared with before treatment, and the improvement effect of the observation group was better than that of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). 4 weeks after treatment, the nasal mucociliary transport rate (MTR) and nasal mucociliary clearance rate (MCC) of the two groups were higher compared with before treatment, and the observation group was higher than the control group (P<0.05). 4 weeks after treatment, the levels of interleukin-5 (IL-5), interleukin-6 (IL-6) and tumor necrosis factor- α (TNF-α) of the two groups were lower than those before treatment, and the observation group was lower than the control group (P<0.05). 4 weeks after treatment, The symptom scores of nasal congestion, dizziness, headache, rhinorrhea, olfactory decline, runny nose and sneezing in the observation group were lower than those in the control group (P<0.05). Conclusion: Tongqiao Biyan tablet combined with clarithromycin has significant efficacy in the treatment of patients with chronic sinusitis, which can effectively improve the olfactory function and nasal mucociliary ciliary transport speed, alleviate clinical symptoms and reduce the level of inflammatory factors, with good safety. |
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